1983
Histopathologic and ultrastructural studies of disseminated cytomegalovirus infection in strain 2 guinea pigs.
Fong C, Lucia H, Bia F, Hsiung G. Histopathologic and ultrastructural studies of disseminated cytomegalovirus infection in strain 2 guinea pigs. Laboratory Investigation 1983, 49: 183-94. PMID: 6308346.Peer-Reviewed Original ResearchConceptsStrain 2 guinea pigsGuinea pigsCytomegalovirus infectionSalivary glandsViral inclusionsCultured guinea pig cellsGuinea pig cytomegalovirus infectionDisseminated cytomegalovirus infectionSevere disseminated diseaseHigh mortality rateUseful animal modelGland duct cellsSalivary gland duct cellsDisseminated diseaseGuinea pig cellsHistologic examinationElectron microscopic examinationAnimal modelsMortality rateVirus inoculationGross lesionsInfectious virusVisceral tissuesPig cellsIntranuclear inclusions
1982
Effects of Vaccination on Cytomegalovirus-Associated Interstitial Pneumonia in Strain 2 Guinea Pigs
Bia F, Lucia H, Fong C, Tarsio M, Hsiung G. Effects of Vaccination on Cytomegalovirus-Associated Interstitial Pneumonia in Strain 2 Guinea Pigs. The Journal Of Infectious Diseases 1982, 145: 742-747. PMID: 6281341, DOI: 10.1093/infdis/145.2.742.Peer-Reviewed Original ResearchConceptsStrain 2 guinea pigsInterstitial pneumoniaCMV infectionGuinea pigsMinimal histopathologic changesTissue culture infective dosesBilateral interstitial pneumoniaEffect of vaccinationStudy of pathogenesisGuinea pig cytomegalovirusHistologic evidenceHistopathologic changesPneumoniaVaccinated animalsInfective dosesCytomegalovirusInfectionLungInfected tissuesPathogenesisPigsTissuePreventionAnimalsViremia
1980
New endogenous herpesvirus of guinea pigs: biological and molecular characterization
Bia F, Summers W, Fong C, Hsiung G. New endogenous herpesvirus of guinea pigs: biological and molecular characterization. Journal Of Virology 1980, 36: 245-253. PMID: 6255209, PMCID: PMC353635, DOI: 10.1128/jvi.36.1.245-253.1980.Peer-Reviewed Original ResearchConceptsGuinea pig herpes-like virusGuinea pig cytomegalovirusGuinea pigsStrain 2 guinea pigsCharacteristic cytopathic effectViral DNACross-neutralization testsVirus-infected cellsGuinea pig cellsRestriction endonuclease cleavage analysisCytopathic effectHerpes-like virusPig cellsHerpesvirusFibroblastic cellsPigsImmunoferritin electron microscopyVirusDistinct patternsCellsEndogenous herpesvirusesMolecular characterizationCytomegalovirusLeukocytes
1979
Cytomegalovirus Infection in Guinea Pigs. III. Persistent Viruria, Blood Transmission, and Viral Interference
Bia F, Hastings K, Hsiung G. Cytomegalovirus Infection in Guinea Pigs. III. Persistent Viruria, Blood Transmission, and Viral Interference. The Journal Of Infectious Diseases 1979, 140: 914-920. PMID: 232118, DOI: 10.1093/infdis/140.6.914.Peer-Reviewed Original ResearchConceptsStrain 2 animalsStrain 2 guinea pigsHerpes-like virusBuffy coatGuinea pig herpes-like virusInfected guinea pigsInbred strain 2 guinea pigsCytomegalovirus infectionBlood recipientsGuinea pigsExperimental CMV infectionsIsolation of cytomegalovirusChronic persistent infectionPigsActive cytomegalovirusUninfected donorsCytomegalovirusPersistent infectionRenal tissueSalivary glandsEndogenous virusInfectious virusViruriaVirusInfection