2012
Modeling human cortical development in vitro using induced pluripotent stem cells
Mariani J, Simonini MV, Palejev D, Tomasini L, Coppola G, Szekely AM, Horvath TL, Vaccarino FM. Modeling human cortical development in vitro using induced pluripotent stem cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 12770-12775. PMID: 22761314, PMCID: PMC3411972, DOI: 10.1073/pnas.1202944109.Peer-Reviewed Original ResearchConceptsHuman brain developmentHuman induced pluripotent stem cellsLayer-specific cortical neuronsBrain developmentHuman cerebral cortexHuman cortical developmentStem cellsPluripotent stem cellsCerebral cortexCortical neuronsCortical developmentCNS regionsRadial gliaCortical wallDorsal telencephalonEmbryonic telencephalonGene expression profilesInduced pluripotent stem cellsIntermediate progenitorsTelencephalic developmentTelencephalonExpression profilesTranscriptional programsCellsGlia
2001
Stem Cells in Neurodevelopment and Plasticity
Vaccarino F, Ganat Y, Zhang Y, Zheng W. Stem Cells in Neurodevelopment and Plasticity. Neuropsychopharmacology 2001, 25: 805-815. PMID: 11750175, DOI: 10.1016/s0893-133x(01)00349-9.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsTranscription factorsProgenitor cellsEpidermal growth factor EGFGrowth factors FGF2Stem cell proliferationGrowth factors EGFPostnatal central nervous systemNuclear transcription factorTranscriptional programsGenetic programGene cascadeNeuronal fateCell-surface interactionsControl proliferationPool of cellsCentral nervous systemEnvironmental perturbationsAdult central nervous systemMolecular signaturesDividing cellsStem cellsCell proliferationEmbryogenesisCell interactions