2024
Opportunities in primary and enteric hyperoxaluria at the cross-roads between the clinic and laboratory
Cellini B, Baum M, Frishberg Y, Groothoff J, Harris P, Hulton S, Knauf F, Knight J, Lieske J, Lowther W, Moochhala S, Nazzal, Tasian G, Whittamore J, Sas D. Opportunities in primary and enteric hyperoxaluria at the cross-roads between the clinic and laboratory. Kidney International Reports 2024 DOI: 10.1016/j.ekir.2024.08.031.Peer-Reviewed Original ResearchPrimäre Hyperoxalurie
Saadé C, Knauf F. Primäre Hyperoxalurie. Nephrologie Aktuell 2024, 28: 272-278. DOI: 10.1055/a-2270-5042.Peer-Reviewed Original ResearchRecovery From Severe Heart Failure in a Patient With Primary Hyperoxaluria Type 1 After Treatment With Lumasiran, Pyridoxine, and Kidney Transplant
Choi M, Kahl A, Hawkins-van der Cingel G, Noriega M, Klingel K, Doeblin P, Schoenrath F, Eckardt K, Öllinger R, Knauf F, Halleck F. Recovery From Severe Heart Failure in a Patient With Primary Hyperoxaluria Type 1 After Treatment With Lumasiran, Pyridoxine, and Kidney Transplant. Annals Of Internal Medicine Clinical Cases 2024, 3 DOI: 10.7326/aimcc.2023.1428.Peer-Reviewed Original ResearchInterleukin-16 is increased in dialysis patients but is not a cardiovascular risk factor
Brösecke F, Pfau A, Ermer T, Dein Terra Mota Ribeiro A, Rubenbauer L, Rao V, Burlein S, Genser B, Reichel M, Aronson P, Coca S, Knauf F. Interleukin-16 is increased in dialysis patients but is not a cardiovascular risk factor. Scientific Reports 2024, 14: 11323. PMID: 38760468, PMCID: PMC11101424, DOI: 10.1038/s41598-024-61808-7.Peer-Reviewed Original ResearchConceptsIL-16 levelsIL-16Dialysis patientsCardiovascular eventsConcentrations of IL-16Kidney failureUremic toxinsCardiovascular diseaseCompared to healthy individualsPlasma oxalate concentrationActivated immune cellsAssociated with cardiovascular diseaseIL-16 concentrationCytokine IL-16Cardiovascular risk factorsNo significant associationPlasma oxalateInflammatory markersImmune cellsCytokine concentrationsInterleukin-16US patientsCohort 1Cardiovascular outcomesHealthy individualsOxalate Metabolism: From Kidney Stones to Cardiovascular Disease
Hawkins-van der Cingel G, Walsh S, Eckardt K, Knauf F. Oxalate Metabolism: From Kidney Stones to Cardiovascular Disease. Mayo Clinic Proceedings 2024, 99: 1149-1161. PMID: 38762815, DOI: 10.1016/j.mayocp.2024.02.006.Peer-Reviewed Original Research
2023
Design Research to Embed mHealth into a Community-Led Blood Pressure Management System in Uganda: Protocol for a Mixed Methods Study
Schwab J, Wachinger J, Munana R, Nabiryo M, Sekitoleko I, Cazier J, Ingenhoff R, Favaretti C, Pillai V, Weswa I, Wafula J, Emmrich J, Bärnighausen T, Knauf F, Knauss S, Nalwadda C, Sudharsanan N, Kalyesubula R, McMahon S. Design Research to Embed mHealth into a Community-Led Blood Pressure Management System in Uganda: Protocol for a Mixed Methods Study. JMIR Research Protocols 2023, 12: e46614. PMID: 38032702, PMCID: PMC10722357, DOI: 10.2196/46614.Peer-Reviewed Original ResearchINTERNATIONAL REGISTERED REPORT IDENTIFIERIntervention prototypeManagement of hypertensionHealth careChronic disease managementMixed-methods studyMobile health interventionsResource-constrained settingsHealth system challengesUncontrolled hypertensionAntihypertensive medicationsGerman RegistryHypertension managementRisk factorsClinical trialsCardiovascular diseaseHypertensionMethods studyBasic health careMedicationsHealth interventionsConcurrent trialsSuch diseasesDisease managementPrivate facilitiesSLC26A6 Plays a Major Role in Release of Soluble Oxalate from Macrophages Following Internalization of Calcium Oxalate Crystals
Najenson A, Wagner T, Bachmann S, Thomson R, Knauf F, Aronson P. SLC26A6 Plays a Major Role in Release of Soluble Oxalate from Macrophages Following Internalization of Calcium Oxalate Crystals. Journal Of The American Society Of Nephrology 2023, 34: 490-490. DOI: 10.1681/asn.20233411s1490b.Peer-Reviewed Original ResearchHeart Failure Recovery After Lumasiran and Isolated Kidney Transplantation in Primary Hyperoxaluria Type 1
der Cingel G, Choi M, Kahl A, Schoenrath F, Rehse G, Eckardt K, Knauf F, Halleck F. Heart Failure Recovery After Lumasiran and Isolated Kidney Transplantation in Primary Hyperoxaluria Type 1. Journal Of The American Society Of Nephrology 2023, 34: 565-565. DOI: 10.1681/asn.20233411s1565d.Peer-Reviewed Original ResearchSystemic Immune Dysregulation in a Mouse Model of Oxalate Nephropathy
Bartolomaeus H, Wimmer M, Rauch A, Anandakumar H, Reichel M, Knauf F, Wilck N. Systemic Immune Dysregulation in a Mouse Model of Oxalate Nephropathy. Journal Of The American Society Of Nephrology 2023, 34: 1021-1021. DOI: 10.1681/asn.20233411s11021c.Peer-Reviewed Original ResearchChallenges to Implementation of Community Health Worker-Led Chronic Obstructive Pulmonary Disease (COPD) Screening and Referral in Rural Uganda: A Qualitative Study using the Implementation Outcomes Framework
Ingenhoff R, Robertson N, Munana R, Bodnar B, Weswa I, Sekitoleko I, Gaal J, Kirenga B, Kalyesubula R, Knauf F, Siddharthan T. Challenges to Implementation of Community Health Worker-Led Chronic Obstructive Pulmonary Disease (COPD) Screening and Referral in Rural Uganda: A Qualitative Study using the Implementation Outcomes Framework. International Journal Of Chronic Obstructive Pulmonary Disease 2023, 18: 2769-2783. PMID: 38046984, PMCID: PMC10693197, DOI: 10.2147/copd.s420137.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseImplementation Outcomes FrameworkCOPD screeningRural UgandaBurden of COPDReferral processCommunity health worker interventionHealth worker interventionObstructive pulmonary diseaseHealthcare providers' perceptionsCause of deathHigh patient volumeCommunity-based interventionsCHW supportCOPD awarenessCOPD careMiddle-income countriesPulmonary diseaseMedication accessBody of evidenceOutcomes FrameworkQualitative studyHealth outcomesProviders' perceptionsPatient volumePrinciples for task shifting hypertension and diabetes screening and referral: a qualitative study exploring patient, community health worker and healthcare professional perceptions in rural Uganda
Ingenhoff R, Munana R, Weswa I, Gaal J, Sekitoleko I, Mutabazi H, Bodnar B, Rabin T, Siddharthan T, Kalyesubula R, Knauf F, Nalwadda C. Principles for task shifting hypertension and diabetes screening and referral: a qualitative study exploring patient, community health worker and healthcare professional perceptions in rural Uganda. BMC Public Health 2023, 23: 881. PMID: 37173687, PMCID: PMC10176286, DOI: 10.1186/s12889-023-15704-w.Peer-Reviewed Original ResearchConceptsCommunity health workersNon-communicable diseasesHealthcare workersRural UgandaHealth workersCHW knowledgeNCD screeningDiabetes mellitusMiddle-income countriesCHW characteristicsHypertensionCHW programsCare deliveryHealthcare accessHealthcare professionalsReferralPatient accessHealthcare systemSuccessful program implementationDiabetesPatientsProfessionals' perceptionsFramework methodFocus group discussionsScreeningStrikingly conserved gene expression changes of polyamine regulating enzymes among various forms of acute and chronic kidney injury
Sieckmann T, Schley G, Ögel N, Kelterborn S, Boivin F, Fähling M, Ashraf M, Reichel M, Vigolo E, Hartner A, Lichtenberger F, Breiderhoff T, Knauf F, Rosenberger C, Aigner F, Schmidt-Ott K, Scholz H, Kirschner K. Strikingly conserved gene expression changes of polyamine regulating enzymes among various forms of acute and chronic kidney injury. Kidney International 2023, 104: 90-107. PMID: 37121432, DOI: 10.1016/j.kint.2023.04.005.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryKidney injuryKidney pathologyExperimental kidney injuryChronic kidney injuryUnilateral ureteral obstructionForms of injuryPolyamine synthesisCyclosporine treatmentArterial hypertensionKidney transplantationUreteral obstructionKidney levelsTissue injuryTubular castsHealthy kidneysHomeostasis contributesInjuryKidneyExperimental modelKidney cell linePutrescine contentReduced expressionGene expression changesTransplantationSputum Microbiome and Chronic Obstructive Pulmonary Disease in a Rural Ugandan Cohort of Well-Controlled HIV Infection
Kayongo A, Bartolomaeus T, Birkner T, Markó L, Löber U, Kigozi E, Atugonza C, Munana R, Mawanda D, Sekibira R, Uwimaana E, Alupo P, Kalyesubula R, Knauf F, Siddharthan T, Bagaya B, Kateete D, Joloba M, Sewankambo N, Jjingo D, Kirenga B, Checkley W, Forslund S. Sputum Microbiome and Chronic Obstructive Pulmonary Disease in a Rural Ugandan Cohort of Well-Controlled HIV Infection. Microbiology Spectrum 2023, 11: e02139-21. PMID: 36790203, PMCID: PMC10100697, DOI: 10.1128/spectrum.02139-21.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseObstructive pulmonary diseaseAntiretroviral therapySputum microbiomeHIV cohortPulmonary diseaseSputum microbiotaRespiratory microbiotaStable chronic obstructive pulmonary diseaseLower respiratory tract microbiotaNoninfectious lung diseasePost-ART initiationRural UgandaRural Ugandan cohortHIV-positive patientsChronic lung inflammationRisk stratification strategiesCross-sectional studyRespiratory tract microbiotaHIV/AIDSCOPD statusHIV suppressionCOPD severityViral suppressionLung inflammationSLC26A1 is a major determinant of sulfate homeostasis in humans
Pfau A, López-Cayuqueo K, Scherer N, Wuttke M, Wernstedt A, Fassrainer D, Smith D, van de Kamp J, Ziegeler K, Eckardt K, Luft F, Aronson P, Köttgen A, Jentsch T, Knauf F. SLC26A1 is a major determinant of sulfate homeostasis in humans. Journal Of Clinical Investigation 2023, 133: e161849. PMID: 36719378, PMCID: PMC9888379, DOI: 10.1172/jci161849.Peer-Reviewed Original ResearchConceptsSulfate homeostasisIntervertebral disc disordersWhole-exome sequencingMajor determinantBack painPatient presentingMusculoskeletal healthDisc disordersPlasma sulfateSulfate reabsorptionFunctional expression assaysCartilage healthHomozygous mutationPotential targetPopulation studiesNumerous physiological processesRecent evidenceExome analysisHomeostasisHyposulfatemiaExpression assaysPivotal roleClinical geneticsAdditional variantsHumans
2022
Oxalate homeostasis
Ermer T, Nazzal L, Tio M, Waikar S, Aronson P, Knauf F. Oxalate homeostasis. Nature Reviews Nephrology 2022, 19: 123-138. PMID: 36329260, PMCID: PMC10278040, DOI: 10.1038/s41581-022-00643-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsKidney diseaseOxalate homeostasisAnti-inflammatory medicationsChronic kidney diseaseKidney replacement therapySudden cardiac deathProgressive kidney diseaseOutlook of patientsOxalate nephropathyCardiovascular complicationsSystemic inflammationCardiac deathReplacement therapySecondary hyperoxaluriaKidney failureElevated plasmaConsequent impairmentNovel therapeuticsPatientsDiseaseEffective elimination strategiesEndogenous sourcesHomeostasisElimination strategyExcretionAuthors’ Reply: Calcium-Based Phosphate Binders and Plasma Oxalate Concentration in Dialysis Patients
Pfau A, Knauf F. Authors’ Reply: Calcium-Based Phosphate Binders and Plasma Oxalate Concentration in Dialysis Patients. Journal Of The American Society Of Nephrology 2022, 33: 1428-1428. PMID: 35500939, PMCID: PMC9257799, DOI: 10.1681/asn.2022030359.Peer-Reviewed Original ResearchEffectiveness of a community health worker-delivered care intervention for hypertension control in Uganda: study protocol for a stepped wedge, cluster randomized control trial
Ingenhoff R, Nandawula J, Siddharthan T, Ssekitoleko I, Munana R, Bodnar B, Weswa I, Kirenga B, Mutungi G, van der Giet M, Kalyesubula R, Knauf F. Effectiveness of a community health worker-delivered care intervention for hypertension control in Uganda: study protocol for a stepped wedge, cluster randomized control trial. Trials 2022, 23: 440. PMID: 35610712, PMCID: PMC9128241, DOI: 10.1186/s13063-022-06403-9.Peer-Reviewed Original ResearchConceptsCommunity health workersNon-communicable diseasesUncontrolled hypertensionBlood pressureCardiovascular disease risk assessmentHealthy lifestyle counselingMonthly household visitsBlood pressure controlSub-Saharan African settingPatient-related factorsPrimary care levelStepped-wedge clusterMedical treatment outcomeMajority of LMICsMulti-component interventionDisease risk assessmentNCD clinicsHypertension controlHypertensive patientsLifestyle counselingAdult patientsHTN managementMiddle-income countriesMedication adherenceEntire cohortHemodialysis and biotransformation of erythrocyte epoxy fatty acids in peripheral tissue
Liu T, Dogan I, Rothe M, Kunz J, Knauf F, Gollasch M, Luft F, Gollasch B. Hemodialysis and biotransformation of erythrocyte epoxy fatty acids in peripheral tissue. Prostaglandins Leukotrienes And Essential Fatty Acids 2022, 181: 102453. PMID: 35633593, DOI: 10.1016/j.plefa.2022.102453.Peer-Reviewed Original ResearchConceptsRed blood cellsHD treatmentHemodialysis treatmentEnd-stage renal disease patientsHydroxyeicosatetraenoic acidHydroxyeicosapentaenoic acidSingle hemodialysis treatmentChronic kidney diseaseRenal disease patientsRenal replacement therapyFatty acid statusVenous blood samplesHydroxydocosahexaenoic acidEpoxy fatty acidsCause of mortalityLOX pathwayRenal failureFatty acidsKidney diseaseDisease patientsVenous bloodCardiovascular functionAcid statusArteriovenous differenceCardiovascular diseaseDifferent Murine Models of Kidney Injury Reveal a Common Pattern of Dysregulation within the Polyamine System in Favour of its Catabolic Pathways
Sieckmann T, Ögel N, Kelterborn S, Boivin F, Schley G, Fähling M, Ashraf M, Reichel M, Vigolo E, Hartner A, Knauf F, Rosenberger C, Aigner F, Smidt‐Ott K, Scholz H, Kirschner K. Different Murine Models of Kidney Injury Reveal a Common Pattern of Dysregulation within the Polyamine System in Favour of its Catabolic Pathways. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r3345.Peer-Reviewed Original ResearchProximal tubulesPolyamine systemKidney ischemia-reperfusion injuryIschemia-reperfusion injuryDifferent murine modelsReperfusion injuryInjury leadMurine modelMouse modelRNA stability assaysCell functionStriking changesRT-qPCRAltered subcellular localizationHypoxiaSimilar changesTubulesInjury expressionDysregulationKidney explantsHyperosmolarityEmbryonic kidney explantsHarmful conditionsExpressionCertain isoformsRandomized Placebo-Controlled Trial of Reloxaliase in Enteric Hyperoxaluria.
Lieske J, Lingeman J, Ferraro P, Wyatt C, Tosone C, Kausz A, Knauf F. Randomized Placebo-Controlled Trial of Reloxaliase in Enteric Hyperoxaluria. NEJM Evidence 2022, 1: evidoa2100053. PMID: 38319254, DOI: 10.1056/evidoa2100053.Peer-Reviewed Original Research