Pre-emptive use of glucose 5% as the standard drug solvent reduces hypernatremia in critically ill patients
Hardenberg J, Kunz J, Rubarth K, Mittermaier M, Pigorsch M, Balzer F, Witzenrath M, Hinz R, Körner R, Eckardt K, Knauf F, Hinrichs C, Enghard P. Pre-emptive use of glucose 5% as the standard drug solvent reduces hypernatremia in critically ill patients. Clinical Kidney Journal 2024, 17: sfae328. PMID: 39582778, PMCID: PMC11584513, DOI: 10.1093/ckj/sfae328.Peer-Reviewed Original ResearchGlucose 5% solutionGlucose 5%Severe hypernatremiaDrug diluentDrug solventSodium concentrationAssociated with increased mortalityResults Baseline characteristicsAdult COVID-19 patientsRetrospective before-and-after studyCritically ill patientsIntensive care unitPre-emptive usePrevalence of hypernatremiaStudy intensive care unitVenous blood gasesLength of stayCOVID-19 patientsBaseline characteristicsClinical outcomesICU admissionHypernatremiaMedical ICUCare unitBlood gases