2022
Different Murine Models of Kidney Injury Reveal a Common Pattern of Dysregulation within the Polyamine System in Favour of its Catabolic Pathways
Sieckmann T, Ögel N, Kelterborn S, Boivin F, Schley G, Fähling M, Ashraf M, Reichel M, Vigolo E, Hartner A, Knauf F, Rosenberger C, Aigner F, Smidt‐Ott K, Scholz H, Kirschner K. Different Murine Models of Kidney Injury Reveal a Common Pattern of Dysregulation within the Polyamine System in Favour of its Catabolic Pathways. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r3345.Peer-Reviewed Original ResearchProximal tubulesPolyamine systemKidney ischemia-reperfusion injuryIschemia-reperfusion injuryDifferent murine modelsReperfusion injuryInjury leadMurine modelMouse modelRNA stability assaysCell functionStriking changesRT-qPCRAltered subcellular localizationHypoxiaSimilar changesTubulesInjury expressionDysregulationKidney explantsHyperosmolarityEmbryonic kidney explantsHarmful conditionsExpressionCertain isoforms
2016
Loss of Cystic Fibrosis Transmembrane Regulator Impairs Intestinal Oxalate Secretion
Knauf F, Thomson RB, Heneghan JF, Jiang Z, Adebamiro A, Thomson CL, Barone C, Asplin JR, Egan ME, Alper SL, Aronson PS. Loss of Cystic Fibrosis Transmembrane Regulator Impairs Intestinal Oxalate Secretion. Journal Of The American Society Of Nephrology 2016, 28: 242-249. PMID: 27313231, PMCID: PMC5198290, DOI: 10.1681/asn.2016030279.Peer-Reviewed Original ResearchConceptsIntestinal oxalate secretionWild-type miceCystic fibrosisIntestinal tissueOxalate secretionIncidence of hyperoxaluriaCalcium oxalate stone formationNet intestinal absorptionOxalate stone formationCoexpression of CFTRIntestinal transport processesWestern blot analysisOxalate absorptionMouse modelIntestinal absorptionGlucose absorptionUssing chambersStone formationFibrosisMiceSecretionReduced expressionCystic fibrosis transmembrane conductance regulator (CFTR) geneHyperoxaluriaPatients
2014
Neue Einblicke in die Pathogenese der Nierensteine
Knauf F. Neue Einblicke in die Pathogenese der Nierensteine. Die Nephrologie 2014, 9: 196-203. DOI: 10.1007/s11560-013-0850-0.Peer-Reviewed Original ResearchRenal stone diseaseStone diseaseMajority of patientsMethodsThis review articleNovel therapeutic agentsPathogenesis of nephrolithiasisSelective literature researchUrine volumeRisk factorsUrine collectionUrine pHCalcium stonesTherapeutic approachesMouse modelStone formationInflammasome responseTherapeutic agentsKidney stonesStone analysisUric acidConcentration of calciumPathogenesisDiseaseReview articleChronic problems