2023
Strikingly conserved gene expression changes of polyamine regulating enzymes among various forms of acute and chronic kidney injury
Sieckmann T, Schley G, Ögel N, Kelterborn S, Boivin F, Fähling M, Ashraf M, Reichel M, Vigolo E, Hartner A, Lichtenberger F, Breiderhoff T, Knauf F, Rosenberger C, Aigner F, Schmidt-Ott K, Scholz H, Kirschner K. Strikingly conserved gene expression changes of polyamine regulating enzymes among various forms of acute and chronic kidney injury. Kidney International 2023, 104: 90-107. PMID: 37121432, DOI: 10.1016/j.kint.2023.04.005.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryKidney injuryKidney pathologyExperimental kidney injuryChronic kidney injuryUnilateral ureteral obstructionForms of injuryPolyamine synthesisCyclosporine treatmentArterial hypertensionKidney transplantationUreteral obstructionKidney levelsTissue injuryTubular castsHealthy kidneysHomeostasis contributesInjuryKidneyExperimental modelKidney cell linePutrescine contentReduced expressionGene expression changesTransplantation
2022
Different Murine Models of Kidney Injury Reveal a Common Pattern of Dysregulation within the Polyamine System in Favour of its Catabolic Pathways
Sieckmann T, Ögel N, Kelterborn S, Boivin F, Schley G, Fähling M, Ashraf M, Reichel M, Vigolo E, Hartner A, Knauf F, Rosenberger C, Aigner F, Smidt‐Ott K, Scholz H, Kirschner K. Different Murine Models of Kidney Injury Reveal a Common Pattern of Dysregulation within the Polyamine System in Favour of its Catabolic Pathways. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r3345.Peer-Reviewed Original ResearchProximal tubulesPolyamine systemKidney ischemia-reperfusion injuryIschemia-reperfusion injuryDifferent murine modelsReperfusion injuryInjury leadMurine modelMouse modelRNA stability assaysCell functionStriking changesRT-qPCRAltered subcellular localizationHypoxiaSimilar changesTubulesInjury expressionDysregulationKidney explantsHyperosmolarityEmbryonic kidney explantsHarmful conditionsExpressionCertain isoforms