2014
E‐NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role
Aldi S, Marino A, Tomita K, Corti F, Anand R, Olson KE, Marcus AJ, Levi R. E‐NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role. The FASEB Journal 2014, 29: 61-69. PMID: 25318477, PMCID: PMC4285537, DOI: 10.1096/fj.14-261867.Peer-Reviewed Original ResearchConceptsRenin releaseRenin-angiotensin systemMast cellsVentricular fibrillationRAS activationHMC-1Murine bone marrow-derived mast cellsLocal renin-angiotensin systemBone marrow-derived mast cellsCardiac mast cellsNovel cardioprotective roleMarrow-derived mast cellsPurinergic P2X7 receptorIschemia/reperfusionHeart mast cellsCD39 inhibitionCD39 overexpressionP2X7R blockadeNorepinephrine overflowCardioprotective effectsCardioprotective roleP2X7 receptorCD39Pharmacological inhibitionATP release
2011
The Expression Level of Ecto-NTP Diphosphohydrolase1/CD39 Modulates Exocytotic and Ischemic Release of Neurotransmitters in a Cellular Model of Sympathetic Neurons
Corti F, Olson K, Marcus A, Levi R. The Expression Level of Ecto-NTP Diphosphohydrolase1/CD39 Modulates Exocytotic and Ischemic Release of Neurotransmitters in a Cellular Model of Sympathetic Neurons. Journal Of Pharmacology And Experimental Therapeutics 2011, 337: 524-532. PMID: 21325440, PMCID: PMC3083107, DOI: 10.1124/jpet.111.179994.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsAntigens, CDApyraseBlotting, WesternDNA PrimersDopamineExocytosisGene Expression Regulation, EnzymologicGene SilencingIschemiaNerve Growth FactorsNeuronsNeurotransmitter AgentsNorepinephrinePC12 CellsPotassiumRatsReceptors, Purinergic P2XReverse Transcriptase Polymerase Chain ReactionRNA, Small InterferingSympathetic Nervous SystemConceptsE-NTPDase1/CD39CD39 expressionTransmitter ATPSympathetic neuronsDopamine releaseExcessive catecholamine releaseNerve growth factor-differentiated PC12 cellsSympathetic nerve terminalsPC12 cellsExocytosis of ATPCellular modelRelease of ATPCD39 overexpressionIschemic releasePrejunctional siteSympathetic nervesCardiac dysfunctionMyocardial ischemiaCatecholamine releaseCD39 deletionNerve terminalsDepolarization-induced exocytosisAutocrine mannerDiphosphohydrolase-1Predominant catecholamine