2013
Triplex-induced DNA damage response.
Rogers FA, Tiwari MK. Triplex-induced DNA damage response. The Yale Journal Of Biology And Medicine 2013, 86: 471-8. PMID: 24348211, PMCID: PMC3848101.Peer-Reviewed Original ResearchConceptsDNA damage responseGenomic integrityDamage responseCellular pathwaysCellular DNA damage responseDNA damageAppropriate cellular responsesPro-apoptotic factorsCell cycle arrestDNA repairDNA strand breaksCellular responsesCycle arrestDamage sitesStrand breaksPathwayApoptosisHelical structureComplex seriesCentral roleTriplex formationXPDPhosphorylationΓH2AXDNAXPD-dependent activation of apoptosis in response to triplex-induced DNA damage
Tiwari M, Rogers FA. XPD-dependent activation of apoptosis in response to triplex-induced DNA damage. Nucleic Acids Research 2013, 41: 8979-8994. PMID: 23913414, PMCID: PMC3799437, DOI: 10.1093/nar/gkt670.Peer-Reviewed Original ResearchConceptsDouble-strand breaksStrand breaksGenomic integrityPro-apoptotic pathwaysHuman genomeTyrosine 142DNA repairDNA sequencesGenomic instabilityDNA strand breaksNoncanonical structuresCancer initiationDNA damageDamage sitesΓH2AX fociHelical distortionApoptosisTriplex structureCentral rolePathwayXPDGenomeTriplexesPhosphorylationΓH2AX
2011
XPD‐Dependent induction of apoptosis in cells with DNA containing triple helical repeats
Rogers F, Kaushik M. XPD‐Dependent induction of apoptosis in cells with DNA containing triple helical repeats. The FASEB Journal 2011, 25: 310.3-310.3. DOI: 10.1096/fasebj.25.1_supplement.310.3.Peer-Reviewed Original ResearchDNA repairH-DNAAltered helical structureNucleotide excision repair pathwayExcision repair pathwayTriple helical repeatsGenomic integrityPro-apoptotic pathwaysHuman genomeInduction of mutationsDNA sequencesRepair pathwaysHelical repeatBase pairsDNA damageIntricate balanceHelical distortionRepair synthesisTriplex structureApoptosisHelical structureCentral roleTriplex formationPathwayInduction