2005
Triplex-forming oligonucleotides as potential tools for modulation of gene expression.
Rogers FA, Lloyd JA, Glazer PM. Triplex-forming oligonucleotides as potential tools for modulation of gene expression. Anti-Cancer Agents In Medicinal Chemistry 2005, 5: 319-26. PMID: 16101484, DOI: 10.2174/1568011054222300.Peer-Reviewed Original ResearchConceptsGene expressionAltered helical structureTarget sequenceSequence-specific mannerGenome modificationGenomic modificationsRepair pathwaysDNA-reactive compoundsOligonucleotide bindsDuplex DNAMajor grooveSpecific sitesHelical structureDual roleExpressionPossible roleCancer therapySequenceTFOGenomeTriplexesPolypyrimidineNumber of studiesDNABinds
2004
Targeted Genome Modification Via Triple Helix Formation
Rogers F, Glazer P. Targeted Genome Modification Via Triple Helix Formation. Cancer Drug Discovery And Development 2004, 27-43. DOI: 10.1007/978-1-59259-777-2_3.Peer-Reviewed Original ResearchDefective geneTargeted genome modificationInhibitors of proteinGene functionGenome modificationGene productsGene expressionTriple helix formationTremendous clinical valueSynthetic oligonucleotidesGenesInherited diseaseHelix formationTreatment of diseasesExpressionDifferent diseasesProteinTherapeutic agentsOligonucleotideTherapeutic useTremendous stridesInhibitorsFunction