2019
Sustained Remission After Maintenance Irinotecan in Patient With Multiply Relapsed Hepatoblastoma
Natarajan E, Auerbach C, Cheron R, Pashankar F. Sustained Remission After Maintenance Irinotecan in Patient With Multiply Relapsed Hepatoblastoma. Journal Of Pediatric Hematology/Oncology 2019, 42: e659-e661. PMID: 31259823, DOI: 10.1097/mph.0000000000001544.Peer-Reviewed Original ResearchConceptsRecurrent hepatoblastomaIfosfamide/carboplatin/etoposide chemotherapyLong-term disease-free survivalCarboplatin/etoposide chemotherapyDisease-free survivalLimited treatment optionsAdjuvant chemotherapySecond relapseEtoposide chemotherapyFirst relapseMultiple relapsesSurgical resectionPoor prognosisTreatment optionsMetastatic hepatoblastomaHepatoblastomaRelapseChemotherapyIrinotecanChildrenRemissionResectionPostresectionPatientsPrognosis
2017
Reduced and Compressed Cisplatin-Based Chemotherapy in Children and Adolescents With Intermediate-Risk Extracranial Malignant Germ Cell Tumors: A Report From the Children’s Oncology Group
Shaikh F, Cullen JW, Olson TA, Pashankar F, Malogolowkin MH, Amatruda JF, Villaluna D, Krailo M, Billmire DF, Rescorla FJ, Egler RA, Dicken BJ, Ross JH, Schlatter M, Rodriguez-Galindo C, Frazier AL. Reduced and Compressed Cisplatin-Based Chemotherapy in Children and Adolescents With Intermediate-Risk Extracranial Malignant Germ Cell Tumors: A Report From the Children’s Oncology Group. Journal Of Clinical Oncology 2017, 35: jco.2016.67.654. PMID: 28240974, PMCID: PMC5455599, DOI: 10.1200/jco.2016.67.6544.Peer-Reviewed Original ResearchConceptsMalignant germ cell tumorsEvent-free survivalCycles of PEBEFS ratesGerm cell tumorsOncology GroupCell tumorsExtracranial malignant germ cell tumorsReduction of therapyChildren's Oncology GroupSingle-arm trialLow-stage tumorsHigh-stage tumorsAdministration of cisplatinEligible patientsComparable patientsHistorical cohortPatientsTumorsStatistical significanceComparable childrenPhase 3ChildrenP-valueOne-sided p-value
2013
Candidate Sequence Variants and Fetal Hemoglobin in Children with Sickle Cell Disease Treated with Hydroxyurea
Green NS, Ender KL, Pashankar F, Driscoll C, Giardina PJ, Mullen CA, Clark LN, Manwani D, Crotty J, Kisselev S, Neville KA, Hoppe C, Barral S. Candidate Sequence Variants and Fetal Hemoglobin in Children with Sickle Cell Disease Treated with Hydroxyurea. PLOS ONE 2013, 8: e55709. PMID: 23409025, PMCID: PMC3567082, DOI: 10.1371/journal.pone.0055709.Peer-Reviewed Original ResearchConceptsSickle cell diseaseFetal hemoglobin levelsHemoglobin levelsCell diseaseFetal hemoglobinBaseline levelsAdult sickle cell diseasePediatric sickle cell diseaseSubset of childrenPharmacologic therapyHydroxyurea therapyClinical severityPediatric diseasesInduced levelsSignificant associationTherapeutic inductionCandidate single nucleotide polymorphismsDiseaseSingle nucleotide polymorphismsHemoglobinSequence variantsChildrenTherapyBaselineHydroxyurea
2012
Children's Oncology Group's 2013 blueprint for research: Rare tumors
Rodriguez‐Galindo C, Krailo M, Frazier L, Chintagumpala M, Amatruda J, Katzenstein H, Malogolowkin M, Spector L, Pashankar F, Meyers R, Tomlinson G, Committee O. Children's Oncology Group's 2013 blueprint for research: Rare tumors. Pediatric Blood & Cancer 2012, 60: 1016-1021. PMID: 23255219, PMCID: PMC4304764, DOI: 10.1002/pbc.24428.Peer-Reviewed Original ResearchConceptsGerm cell tumorsCell tumorsRare cancersChildren's Oncology Group's 2013 blueprintInternational phase 3 clinical trialsPhase 3 clinical trialsEvidence-based definitionIntraocular retinoblastomaAdvanced carcinomaRisk stratificationInfrequent malignancyRare tumorClinical trialsClinical studiesLiver tumorsTumorsBiologic studiesChildrenCancerRetinoblastomaCarcinomaMalignancyHepatoblastomaYearsTrialsDevelopment of a Therapeutic Approach to Rare Cancers in Children
Pashankar FD, Rodriguez-Galindo C, Pappo A. Development of a Therapeutic Approach to Rare Cancers in Children. Journal Of Pediatric Hematology/Oncology 2012, 34: s37-s38. PMID: 22525404, DOI: 10.1097/mph.0b013e31824e378e.Peer-Reviewed Original ResearchManagement of Ovarian and Testicular Sex Cord-stromal Tumors in Children and Adolescents
Schultz KA, Schneider DT, Pashankar F, Ross J, Frazier L. Management of Ovarian and Testicular Sex Cord-stromal Tumors in Children and Adolescents. Journal Of Pediatric Hematology/Oncology 2012, 34: s55-s63. PMID: 22525408, DOI: 10.1097/mph.0b013e31824e3867.Peer-Reviewed Original ResearchConceptsSex cord-stromal tumorsTesticular sex cord-stromal tumorsOvarian sex cord-stromal tumorsManagement of ovarianTesticular stromal tumorsHigh-risk diseaseGerm cell neoplasmsOptimal treatment strategyMultiagent chemotherapyObstetrics classificationPalpable massBenign courseRisk diseaseStromal tumorsRare tumorSpecific genetic syndromesOvarian carcinomaCell neoplasmsTreatment strategiesHormone productionTumorsGenetic syndromesInternational FederationAdditional researchChildren
2011
Acute Constipation in Children Receiving Chemotherapy for Cancer
Pashankar FD, Season JH, McNamara J, Pashankar DS. Acute Constipation in Children Receiving Chemotherapy for Cancer. Journal Of Pediatric Hematology/Oncology 2011, 33: e300-e303. PMID: 21941132, DOI: 10.1097/mph.0b013e31821a0795.Peer-Reviewed Original ResearchConceptsDevelopment of constipationAcute constipationRisk factorsBowel movement patternDiagnosis of constipationSeverity of constipationUse of vincristineSignificant risk factorsAggressive managementGroup of childrenPediatric GastroenterologyConstipationChemotherapyNutrition criteriaMore weeksCancerParental perceptionsNorth American SocietySignificant problemAmerican SocietyChildrenVincristineOpiatesLifestyleCombined use
2005
MIBG and somatostatin receptor analogs in children: current concepts on diagnostic and therapeutic use.
Pashankar FD, O'Dorisio MS, Menda Y. MIBG and somatostatin receptor analogs in children: current concepts on diagnostic and therapeutic use. Journal Of Nuclear Medicine 2005, 46 Suppl 1: 55s-61s. PMID: 15653652.Peer-Reviewed Original ResearchMeSH Keywords3-IodobenzylguanidineAnimalsChildChild, PreschoolClinical Trials as TopicHumansInfantInfant, NewbornNeuroblastomaOctreotidePatient SelectionPentetic AcidPractice Guidelines as TopicPractice Patterns, Physicians'Radiation InjuriesRadionuclide ImagingRadiopharmaceuticalsSomatostatinTreatment OutcomeConceptsSolid tumorsCertain pediatric tumorsSomatostatin receptor analoguesPediatric solid tumorsMetaiodobenzylguanidine scanNuclear imaging techniquesBone scanPediatric tumorsFalse transmitterTherapeutic useCell membrane receptorsReceptor analoguesYoung adultsTumorsMolecular targetsCurrent conceptsMIBGScansMembrane receptorsSpecific ligandsImaging techniquesChildrenSubcellular organellesCellular proteinsDiagnosis
2001
Successful Chemotherapeutic Decompression of Primary Endodermal Sinus Tumor Presenting With Severe Spinal Cord Compression
Pashankar F, Steinbok P, Blair G, Pritchard S. Successful Chemotherapeutic Decompression of Primary Endodermal Sinus Tumor Presenting With Severe Spinal Cord Compression. Journal Of Pediatric Hematology/Oncology 2001, 23: 170-173. PMID: 11305721, DOI: 10.1097/00043426-200103000-00010.Peer-Reviewed Original ResearchConceptsEndodermal sinus tumorSpinal cord compressionCord compressionRadiation therapySevere spinal cord compressionEpidural cord compressionExcellent tumor responseComplete neurologic recoveryCisplatin-based chemotherapyNeurologic recoverySinus tumorComplete paraplegiaTumor PresentingTumor responseRapid resolutionLaminectomyChemotherapyTherapyChildren
2000
Analysis of the intracellular signalling domain of the human growth hormone receptor in children with idiopathic short stature
Johnston L, Pashankar F, Camacho‐Hübner C, Savage M, Clark A. Analysis of the intracellular signalling domain of the human growth hormone receptor in children with idiopathic short stature. Clinical Endocrinology 2000, 52: 463-469. PMID: 10762289, DOI: 10.1046/j.1365-2265.2000.00940.x.Peer-Reviewed Original ResearchConceptsGrowth hormone insensitivityIdiopathic short staturePartial growth hormone insensitivityGrowth hormone receptorHormone insensitivityShort statureSerum IGF-I levelsHormone receptorsShort stature subjectsIGF-I levelsGH provocation testsProvocation testExon 9GH deficiencyControl populationCodon 325Protein levelsAmino acid changesPatientsHuman growth hormone receptorCentileDominant-negative variantChildrenSubjectsDominant negative mutation