2015
Chitinase 3–like-1 Regulates Both Visceral Fat Accumulation and Asthma-like Th2 Inflammation
Ahangari F, Sood A, Ma B, Takyar S, Schuyler M, Qualls C, Dela Cruz CS, Chupp GL, Lee CG, Elias JA. Chitinase 3–like-1 Regulates Both Visceral Fat Accumulation and Asthma-like Th2 Inflammation. American Journal Of Respiratory And Critical Care Medicine 2015, 191: 746-757. PMID: 25629580, PMCID: PMC4407482, DOI: 10.1164/rccm.201405-0796oc.Peer-Reviewed Original ResearchConceptsHigh-fat dietTh2 inflammationTh2 responsesFat accumulationChitinase 3Genesis of obesityRole of CHI3L1Lower lung functionLean control subjectsVisceral fat accumulationPathogenesis of asthmaWhite adipose tissue accumulationAdipose tissue accumulationCase-control studySerum CHI3L1Truncal adiposityWAT accumulationPersistent asthmaTruncal obesityLung functionObese subjectsVisceral fatAsthma incidenceControl subjectsRisk factors
2013
VEGF controls lung Th2 inflammation via the miR-1–Mpl (myeloproliferative leukemia virus oncogene)–P-selectin axis
Takyar S, Vasavada H, Zhang JG, Ahangari F, Niu N, Liu Q, Lee CG, Cohn L, Elias JA. VEGF controls lung Th2 inflammation via the miR-1–Mpl (myeloproliferative leukemia virus oncogene)–P-selectin axis. Journal Of Experimental Medicine 2013, 210: 1993-2010. PMID: 24043765, PMCID: PMC3782056, DOI: 10.1084/jem.20121200.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorTh2 inflammationLung endotheliumMiR-1Th2-mediated lung inflammationIL-13 overexpressionLung-specific overexpressionHouse dust mitePotential therapeutic targetEndothelial growth factorMiR-1 expressionLung inflammationInflammatory disordersDust miteInflammation modelInflammatory responseIntranasal deliveryRole of microRNAsTherapeutic targetInflammationP-selectinGrowth factorVivo knockdownEffector pathwaysEndothelium