2021
Examining the effect of obesity-associated gene variants on breast cancer survivors in a randomized weight loss intervention
Nguyen T, Irwin ML, Dewan AT, Cartmel B, Harrigan M, Ferrucci LM, Sanft T, Li F, Lu L, Salinas YD. Examining the effect of obesity-associated gene variants on breast cancer survivors in a randomized weight loss intervention. Breast Cancer Research And Treatment 2021, 187: 487-497. PMID: 33677781, DOI: 10.1007/s10549-021-06151-5.Peer-Reviewed Original ResearchMeSH KeywordsAlpha-Ketoglutarate-Dependent Dioxygenase FTOBody Mass IndexBreast NeoplasmsCancer SurvivorsFemaleGenotypeHumansObesityPolymorphism, Single NucleotideWeight LossConceptsBreast cancer survivorsUsual care groupWeight loss interventionCancer survivorsLoss interventionCare groupFTO rs9939609Percent body fat changesWeight lossMeaningful weight lossBody fat changesBody mass indexObesity-associated gene FTOObesity-associated gene variantsPercent body fatGreater weight lossLifestyle interventionMass indexTreatment armsIntervention groupBreast cancerBody fatFat changesPurposeOur studyHealthy eating
2014
Effect of vitamin D–binding protein genotype on the development of asthma in children
Navas-Nazario A, Li FY, Shabanova V, Weiss P, Cole DE, Carpenter TO, Bazzy-Asaad A. Effect of vitamin D–binding protein genotype on the development of asthma in children. Annals Of Allergy Asthma & Immunology 2014, 112: 519-524. PMID: 24745702, PMCID: PMC4070170, DOI: 10.1016/j.anai.2014.03.017.Peer-Reviewed Original ResearchMeSH KeywordsAsthmaChild, PreschoolCholestanetriol 26-MonooxygenaseConnecticutCytochrome P450 Family 2FemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHispanic or LatinoHumansInfantMalePolymorphism, Single NucleotideReceptors, CalcitriolRetrospective StudiesVitamin DVitamin D-Binding ProteinConceptsDevelopment of asthmaVitamin DGC genotypeVitamin D metabolite levelsRetrospective medical record reviewVitamin D insufficiencyMedical record reviewCurrent clinical dataSingle nucleotide polymorphismsVitamin D metabolitesGC single nucleotide polymorphismsHispanic populationPotential vitamin DMonths of ageD insufficiencyAsthma morbidityHealthy infantsRecord reviewD metabolitesHealthy childrenInflammatory diseasesNucleotide polymorphismsClinical dataProtective effectAsthma
2013
Leptin Signaling and Hyperparathyroidism: Clinical and Genetic Associations
Hoang D, Broer N, Roman SA, Yao X, Abitbol N, Li F, Sosa JA, Sue GR, DeWan AT, Wong ML, Licinio J, Simpson C, Li AY, Pizzoferrato N, Narayan D. Leptin Signaling and Hyperparathyroidism: Clinical and Genetic Associations. Journal Of The American College Of Surgeons 2013, 218: 1239-1250.e4. PMID: 24468228, DOI: 10.1016/j.jamcollsurg.2013.11.013.Peer-Reviewed Original ResearchConceptsParathyroid hormone levelsLeptin levelsParathyroid glandsHormone levelsBaseline leptin levelsLarge parathyroid glandsBody mass indexRole of leptinWilcoxon signed-rank testHyperplasia subgroupsParathyroid sizeObese patientsPostoperative changesMass indexParathyroid adenomaProspective studyParathyroid tissueBland-Altman methodLeptin productionSigned-rank testSurgical conditionsClinical studiesLeptin signalingLEPR polymorphismsLeptin