2014
Characterization of a lanthanide complex encapsulated with MRI contrast agents into liposomes for biosensor imaging of redundant deviation in shifts (BIRDS)
Maritim S, Huang Y, Coman D, Hyder F. Characterization of a lanthanide complex encapsulated with MRI contrast agents into liposomes for biosensor imaging of redundant deviation in shifts (BIRDS). JBIC Journal Of Biological Inorganic Chemistry 2014, 19: 1385-1398. PMID: 25304046, PMCID: PMC4348029, DOI: 10.1007/s00775-014-1200-z.Peer-Reviewed Original ResearchConceptsLanthanide complexesMagnetic resonance imaging (MRI) probesParamagnetic lanthanide complexesT2 contrast agentsRedundant deviationMolecular imagingMRI contrast agentsNon-exchangeable protonsContrast agentsMRI contrastChemical shiftsMRI probesLiposomal encapsulation efficiencyParamagnetic environmentSignal amplificationEncapsulation efficiencyWater relaxationProbe environmentTransverse relaxation timeParamagnetic effectImaging probeHigh spatial resolutionParamagnetic agentsParamagnetic contrast agentRelaxation time
2013
In vivo three‐dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolution
Coman D, de Graaf R, Rothman DL, Hyder F. In vivo three‐dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolution. NMR In Biomedicine 2013, 26: 1589-1595. PMID: 23881869, PMCID: PMC3800475, DOI: 10.1002/nbm.2995.Peer-Reviewed Original ResearchConceptsK-spaceNonexchanging protonsThree-dimensional molecular imagingParamagnetic lanthanide ionsRedundant deviationChemical shift imagingField of viewMolecular imaging capabilitiesMolecular imagingRapid data acquisitionProton detectionLanthanide ionsTens of minutesImaging capabilitiesMacrocyclic chelatesSpectroscopic signalsMacrocyclicCSI experimentsRelaxation timeHigh spatiotemporal resolutionParamagnetic agents
2004
Dynamic Imaging of Perfusion and Oxygenation by Functional Magnetic Resonance Imaging
Kida I, Maciejewski P, Hyder F. Dynamic Imaging of Perfusion and Oxygenation by Functional Magnetic Resonance Imaging. Cerebrovascular And Brain Metabolism Reviews 2004, 24: 1369-1381. DOI: 10.1097/00004647-200412000-00006.Peer-Reviewed Original ResearchT1-weighted MRI signalPeak CBF responseLaser Doppler measurementsBlood oxygenation level-dependent (BOLD) image contrastApparent longitudinal relaxation timeGood agreementTransfer functionImage contrastAngle dataStationary spinsExcitation flip angleMRI signalMRI schemeSignalsSimultaneous imagingWaterAngleRelaxation timeFlip angleMagnetic labelingDifferent flip anglesMeasurementsWater functions
1991
Applications of nuclear magnetic cross‐relaxation spectroscopy to tissues
Grad J, Mendelson D, Hyder F, Bryant R. Applications of nuclear magnetic cross‐relaxation spectroscopy to tissues. Magnetic Resonance In Medicine 1991, 17: 452-459. PMID: 2062216, DOI: 10.1002/mrm.1910170216.Peer-Reviewed Original ResearchConceptsCross-relaxation spectroscopyFundamental relaxation timeMagnetic imagingMagnetic imagesMagnetic relaxationDecay constantsAqueous heterogeneous systemsRelaxation timeWater spinsSpinNMR spectraRelaxationFrequency responseSpectroscopySpectraExperimental approachSignal intensitySystem mixtureIntensityConstantsImaging