2022
Modern Day Wearables to Evade the Widow-Ghost in Brugada Syndrome From Mythology to Deep-Learning Methodology ∗
Karam CS, Akar FG. Modern Day Wearables to Evade the Widow-Ghost in Brugada Syndrome From Mythology to Deep-Learning Methodology ∗. JACC Clinical Electrophysiology 2022, 8: 1021-1023. PMID: 35981789, DOI: 10.1016/j.jacep.2022.06.017.Commentaries, Editorials and Letters
2019
Recurrence quantification analysis of complex‐fractionated electrograms differentiates active and passive sites during atrial fibrillation
Baher A, Buck B, Fanarjian M, Mounsey J, Gehi A, Chung E, Akar FG, Webber CL, Akar JG, Hummel JP. Recurrence quantification analysis of complex‐fractionated electrograms differentiates active and passive sites during atrial fibrillation. Journal Of Cardiovascular Electrophysiology 2019, 30: 2229-2238. PMID: 31507008, DOI: 10.1111/jce.14161.Peer-Reviewed Original Research
2018
Acute Left Ventricular Unloading Reduces Atrial Stretch and Inhibits Atrial Arrhythmias
Ishikawa K, Watanabe S, Lee P, Akar FG, Lee A, Bikou O, Fish K, Kho C, Hajjar RJ. Acute Left Ventricular Unloading Reduces Atrial Stretch and Inhibits Atrial Arrhythmias. Journal Of The American College Of Cardiology 2018, 72: 738-750. PMID: 30092950, PMCID: PMC6160394, DOI: 10.1016/j.jacc.2018.05.059.Peer-Reviewed Original ResearchConceptsLV end-diastolic pressureEnd-diastolic pressureLV unloadingMyocardial infarctionSubacute myocardial infarctionPressure-volume loopsLA pressureAortic regurgitationRyanodine receptor phosphorylationLA tissuesLV loadingReduced LV ejection fractionAtrial arrhythmia inducibilityLV assist deviceLV ejection fractionMean LA pressureLeft ventricular performancePressure-volume catheterMaximum LA volumeLV loading conditionsReceptor phosphorylationMedian 55NOX2 levelsArrhythmia inducibilityAtrial stretch
2014
A formidable “TASK”: Tipping the balance in favor of rhythm control for the management of atrial fibrillation
Akar FG. A formidable “TASK”: Tipping the balance in favor of rhythm control for the management of atrial fibrillation. Heart Rhythm 2014, 11: 1806-1807. PMID: 25041966, DOI: 10.1016/j.hrthm.2014.07.018.Commentaries, Editorials and Letters
2005
Molecular mechanisms underlying K+ current downregulation in canine tachycardia-induced heart failure
Akar FG, Wu RC, Juang GJ, Tian Y, Burysek M, DiSilvestre D, Xiong W, Armoundas AA, Tomaselli GF. Molecular mechanisms underlying K+ current downregulation in canine tachycardia-induced heart failure. AJP Heart And Circulatory Physiology 2005, 288: h2887-h2896. PMID: 15681701, DOI: 10.1152/ajpheart.00320.2004.Peer-Reviewed Original Research
2004
Functional Integration of Electrically Active Cardiac Derivatives From Genetically Engineered Human Embryonic Stem Cells With Quiescent Recipient Ventricular Cardiomyocytes
Xue T, Cho HC, Akar FG, Tsang SY, Jones SP, Marbán E, Tomaselli GF, Li RA. Functional Integration of Electrically Active Cardiac Derivatives From Genetically Engineered Human Embryonic Stem Cells With Quiescent Recipient Ventricular Cardiomyocytes. Circulation 2004, 111: 11-20. PMID: 15611367, DOI: 10.1161/01.cir.0000151313.18547.a2.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAdrenergic beta-AgonistsAnimalsCell DifferentiationCell FusionCells, CulturedDefective VirusesElectrophysiologyFemaleGenes, ReporterGenetic VectorsGiant CellsGreen Fluorescent ProteinsGuinea PigsHeartHeart Conduction SystemHeart VentriclesHIV-1HumansIsoproterenolLidocaineMiceMyocardial ContractionMyocytes, CardiacOrgan Culture TechniquesPericardiumPluripotent Stem CellsPyrimidinesRatsTransduction, GeneticConceptsVentricular cardiomyocytesCardiac impulse generationBeta-adrenergic agonist isoproterenolGuinea pig heartsSite of injectionStem cellsHuman embryonic stem cellsCell-based therapiesContractile activityAgonist isoproterenolPharmacological agentsVentricular myocardiumLeft ventricleEx vivoDonor cardiomyocytesPig heartsHuman cardiomyocytesRecombinant lentivirusMembrane depolarizationCardiomyocytesFunctional syncytiumImpulse generationEmbryonic stem cellsMyocardiumEpicardial surface