2024
Mitochondrial network remodeling of the diabetic heart: implications to ischemia related cardiac dysfunction
Rudokas M, McKay M, Toksoy Z, Eisen J, Bögner M, Young L, Akar F. Mitochondrial network remodeling of the diabetic heart: implications to ischemia related cardiac dysfunction. Cardiovascular Diabetology 2024, 23: 261. PMID: 39026280, PMCID: PMC11264840, DOI: 10.1186/s12933-024-02357-1.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesMitochondrial network remodelingDamaged mitochondrial DNAEfficiency of oxidative phosphorylationImpaired ATP productionMitochondrial ultrastructural alterationsCardiac functionDiabetic heartCellular energy metabolismProduction of reactive oxygen speciesMitochondrial DNAMitochondrial networkMitochondrial fissionExcessive production of reactive oxygen speciesOxidative phosphorylationATP productionResponse to ischemic insultGlobal cardiac functionCell deathOverall cardiac functionCardiac ischemic injuryResponse to injuryCardiac mitochondriaIrreversible cell deathMitochondria
2015
LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation
Kim GE, Ross JL, Xie C, Su KN, Zaha VG, Wu X, Palmeri M, Ashraf M, Akar JG, Russell KS, Akar FG, Young LH. LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation. Cardiovascular Research 2015, 108: 197-208. PMID: 26378152, PMCID: PMC4571838, DOI: 10.1093/cvr/cvv212.Peer-Reviewed Original ResearchConceptsLiver kinase B1Protein kinaseLKB1 deletionMetabolic regulator AMPAtrial fibrillationChannel expressionMHC-CreElectrophysiological functionKnockout mouse modelRelated kinasesLKB1 pathwayGene expressionPerpetuation of AFKinase B1Neonatal atrial myocytesΑMHC-CreKinasePostnatal day 1Patch-clamp recordingsAtrial growthWeeks of ageDeletionSodium current densityAction potential generationSpecific role
2011
Mitochondria are sources of metabolic sink and arrhythmias
Akar FG, O'Rourke B. Mitochondria are sources of metabolic sink and arrhythmias. Pharmacology & Therapeutics 2011, 131: 287-294. PMID: 21513732, PMCID: PMC3138548, DOI: 10.1016/j.pharmthera.2011.04.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArrhythmias, CardiacCalciumHumansMitochondria, HeartMyocytes, CardiacSignal Transduction
2010
Regression of Cardiac Hypertrophy by Cyclic Guanosine Monophosphate-Dependent Protein Kinase Signaling Are Myocytes Active Sources or Mere Beneficiaries?⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Hajjar RJ, Akar FG. Regression of Cardiac Hypertrophy by Cyclic Guanosine Monophosphate-Dependent Protein Kinase Signaling Are Myocytes Active Sources or Mere Beneficiaries?⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology. Journal Of The American College Of Cardiology 2010, 56: 2031-2032. PMID: 20970281, DOI: 10.1016/j.jacc.2010.09.005.Commentaries, Editorials and LettersA brighter side of ROS revealed by selective activation of β‐adrenergic receptor subtypes
Biary N, Akar FG. A brighter side of ROS revealed by selective activation of β‐adrenergic receptor subtypes. The Journal Of Physiology 2010, 588: 2973-2974. PMID: 20710039, PMCID: PMC2956937, DOI: 10.1113/jphysiol.2010.195743.Commentaries, Editorials and LettersAdrenergic beta-1 Receptor AgonistsAdrenergic beta-2 Receptor AgonistsAnimalsGTP-Binding Protein alpha Subunits, Gi-GoHomeostasisHumansMyocytes, CardiacNitric OxideNitric Oxide Synthase Type IIIOxygenRatsReactive Oxygen SpeciesReceptors, Adrenergic, beta-1Receptors, Adrenergic, beta-2Signal Transduction
2008
Key pathways associated with heart failure development revealed by gene networks correlated with cardiac remodeling
Gao Z, Barth AS, DiSilvestre D, Akar FG, Tian Y, Tanskanen A, Kass DA, Winslow RL, Tomaselli GF. Key pathways associated with heart failure development revealed by gene networks correlated with cardiac remodeling. Physiological Genomics 2008, 35: 222-230. PMID: 18780759, PMCID: PMC2585017, DOI: 10.1152/physiolgenomics.00100.2007.Peer-Reviewed Original Research