Bioartificial Sinus Node Constructed via In Vivo Gene Transfer of an Engineered Pacemaker HCN Channel Reduces the Dependence on Electronic Pacemaker in a Sick-Sinus Syndrome Model
Tse HF, Xue T, Lau CP, Siu CW, Wang K, Zhang QY, Tomaselli GF, Akar FG, Li RA. Bioartificial Sinus Node Constructed via In Vivo Gene Transfer of an Engineered Pacemaker HCN Channel Reduces the Dependence on Electronic Pacemaker in a Sick-Sinus Syndrome Model. Circulation 2006, 114: 1000-1011. PMID: 16923751, DOI: 10.1161/circulationaha.106.615385.Peer-Reviewed Original ResearchAnimalsArrhythmias, CardiacBioartificial OrgansCyclic Nucleotide-Gated Cation ChannelsDisease Models, AnimalElectrophysiologyGene Transfer TechniquesGuinea PigsHeart RateHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsIon ChannelsMicePacemaker, ArtificialPotassium ChannelsSick Sinus SyndromeSinoatrial NodeSwineSwine, Miniature