Modulated Dispersion Explains Changes in Arrhythmia Vulnerability During Premature Stimulation of the Heart
Laurita K, Girouard S, Akar F, Rosenbaum D. Modulated Dispersion Explains Changes in Arrhythmia Vulnerability During Premature Stimulation of the Heart. Circulation 1998, 98: 2774-2780. PMID: 9851966, DOI: 10.1161/01.cir.98.24.2774.Peer-Reviewed Original ResearchConceptsVentricular fibrillation thresholdSingle premature stimulusPremature stimuliArrhythmia vulnerabilityBaseline levelsPremature stimulationS1S2 intervalRepolarization gradientsGuinea pig heartsBaseline pacingFibrillation thresholdArrhythmogenic substrateVentricular fibrillationVentricular sitesStimulus-induced changesVentricular repolarizationCoupling intervalCardiac arrhythmiasS2 beatElectrophysiological propertiesAction potentialsOptical action potentialsHeterogeneous electrophysiological propertiesPig heartsRepolarization