07 Mitochondrial hexokinase II is essential for cardiac function and ischaemic preconditioning
Smeele K, Southworth R, Wu R, Xie C, Nederlof R, Warley A, Koeman A, Eerbeek O, Akar F, Ardehali H, Hollmann M, Zuurbier C. 07 Mitochondrial hexokinase II is essential for cardiac function and ischaemic preconditioning. Heart 2011, 97: e8. DOI: 10.1136/heartjnl-2011-301156.7.Peer-Reviewed Original ResearchIschemic preconditioningCardiac functionWT heartsProtective effectBaseline cardiac functionNormal cardiac functionMitochondrial permeability transition openingContractile impairmentIR injuryReperfusion injuryAcute reductionMyocardial functionGlycolytic enzymes hexokinaseMitochondrial hexokinase-IIEx vivoCardiac contractionMild mitochondrial uncouplingMitochondrial membrane depolarisationMembrane depolarisationHexokinase IIHKIIHeartMitochondrial swellingTissue disruptionInjury