2012
GSH or Palmitate Preserves Mitochondrial Energetic/Redox Balance, Preventing Mechanical Dysfunction in Metabolically Challenged Myocytes/Hearts From Type 2 Diabetic Mice
Tocchetti CG, Caceres V, Stanley BA, Xie C, Shi S, Watson WH, O’Rourke B, Spadari-Bratfisch RC, Cortassa S, Akar FG, Paolocci N, Aon MA. GSH or Palmitate Preserves Mitochondrial Energetic/Redox Balance, Preventing Mechanical Dysfunction in Metabolically Challenged Myocytes/Hearts From Type 2 Diabetic Mice. Diabetes 2012, 61: 3094-3105. PMID: 22807033, PMCID: PMC3501888, DOI: 10.2337/db12-0072.Peer-Reviewed Original ResearchConceptsMechanical dysfunctionReactive oxygen speciesType 2 diabetic db/db miceDiabetic db/db miceHigh glucoseType 2 diabetic patientsType 2 diabetic miceDb/db miceLower cardiac performanceLimited exercise capacityPoor glycemic controlType 2 diabetesΒ-agonist isoproterenolCardiac work demandsFatty acid palmitateExercise capacitySympathetic driveGlycemic controlDiabetic patientsDiabetic miceDb miceHeart dysfunctionPatient's inabilityMitochondrial reactive oxygen speciesHeart preparation
2009
Mechanoelectrical remodeling and arrhythmias during progression of hypertrophy
Jin H, Chemaly ER, Lee A, Kho C, Hadri L, Hajjar RJ, Akar FG. Mechanoelectrical remodeling and arrhythmias during progression of hypertrophy. The FASEB Journal 2009, 24: 451-463. PMID: 19825979, PMCID: PMC2812033, DOI: 10.1096/fj.09-136622.Peer-Reviewed Original ResearchConceptsConduction delayLeft ventricular mechanical dysfunctionEnd-stage heart failureTissue levelsVentricular mechanical dysfunctionIncidence of arrhythmiasSudden cardiac deathZO-1Pressure overload hypertrophyAction potential prolongationProgression of hypertrophyDisease developmentLV dysfunctionCardiac deathDephosphorylation of Cx43Heart failureAortic bandingElectrical remodelingVentricular tachycardiaMechanical dysfunctionOverload hypertrophyElectrophysiological changesRat modelPotential prolongationProtein ZO-1
2008
Electrophysiological remodeling in Dilated Cardiomyopathy and Heart Failure
Akar F, Tomaselli G. Electrophysiological remodeling in Dilated Cardiomyopathy and Heart Failure. 2008, 290-304. DOI: 10.1007/978-1-84628-854-8_19.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHeart failureCardiac remodelingComplete heart blockStructural heart diseaseAtrial fibrillationHeart blockMyocardial infarctionVentricular pacingElectrophysiological remodelingHeart diseaseMechanical dysfunctionHeart ratePersistent changesRemodelingActivation sequenceEntire organKey regulatory proteinsGene expressionExtracellular matrixInfarctionTachycardiaCardiomyopathyFailureDysfunctionFibrillation
2007
Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure
Akar FG, Nass RD, Hahn S, Cingolani E, Shah M, Hesketh GG, DiSilvestre D, Tunin RS, Kass DA, Tomaselli GF. Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure. AJP Heart And Circulatory Physiology 2007, 293: h1223-h1230. PMID: 17434978, DOI: 10.1152/ajpheart.00079.2007.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCardiac Pacing, ArtificialConnexin 43Disease Models, AnimalDogsDown-RegulationGap JunctionsHeart Conduction SystemHeart FailureMalePhosphorylationProtein IsoformsTachycardia, VentricularTime FactorsVentricular Function, LeftVentricular PressureVentricular RemodelingConceptsEnd-stage heart failureHeart failureConduction velocityMechanical dysfunctionCV slowingPacing-induced heart failureDevelopment of HFOnset of HFMechanical functionCx43 isoformConduction abnormalitiesCx43 lateralizationAdvanced stageBaseline levelsMyocardial preparationsPhosphorylation of Cx43High-resolution optical mappingSustained downregulationMarked increaseDephosphorylated Cx43LVEDPGap junction propertiesConduction changesDysfunctionTime course