Targeted deletion of kcne2 impairs ventricular repolarization via disruption of IK,slow1 and Ito,f
Roepke TK, Kontogeorgis A, Ovanez C, Xu X, Young JB, Purtell K, Goldstein PA, Christini DJ, Peters NS, Akar FG, Gutstein DE, Lerner DJ, Abbott GW. Targeted deletion of kcne2 impairs ventricular repolarization via disruption of IK,slow1 and Ito,f. The FASEB Journal 2008, 22: 3648-3660. PMID: 18603586, PMCID: PMC2537427, DOI: 10.1096/fj.08-110171.Peer-Reviewed Original ResearchConceptsAlpha subunitKv4 alpha subunitsAction potential durationVentricular action potential durationFunctional promiscuityVentricular membrane fractionsLong QT syndromeVentricular repolarizationAncillary subunitsWild typeNovel roleMembrane fractionKcne2 deletionKv1.5 proteinTargeted deletionSubunitsKcne2 disruptionMiRP1Cardiac roleProteinKCNE2DeletionKv1.5Sevoflurane anesthesiaDisruption