Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes†
Aiba T, Hesketh GG, Liu T, Carlisle R, Villa-Abrille MC, O'Rourke B, Akar FG, Tomaselli GF. Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes†. Cardiovascular Research 2009, 85: 454-463. PMID: 19797425, PMCID: PMC2802203, DOI: 10.1093/cvr/cvp324.Peer-Reviewed Original ResearchConceptsAutocamtide-2-related inhibitory peptideDependent protein kinase IIProtein kinase IIKinase IIChannel gatingGlutathione S-transferase fusion peptidesCAMP-dependent proteinIQ-like motifSpecific CaMKII inhibitorC-terminusChannel regulationPresence of CaMInactivation phenotypeCaMKIICaMKII inhibitorFusion peptideInactivationSlow inactivationFraction of channelsDistinct effectsInhibitorsPeptidesInhibitory peptidesGatingCalmodulin