2014
Gene therapies for arrhythmias in heart failure
Akar FG, Hajjar RJ. Gene therapies for arrhythmias in heart failure. Pflügers Archiv - European Journal Of Physiology 2014, 466: 1211-1217. PMID: 24566976, PMCID: PMC4070506, DOI: 10.1007/s00424-014-1485-3.Peer-Reviewed Original Research
2010
Left ventricular repolarization heterogeneity as an arrhythmic substrate in heart failure.
Akar FG. Left ventricular repolarization heterogeneity as an arrhythmic substrate in heart failure. Minerva Cardioangiologica 2010, 58: 205-12. PMID: 20440250.ChaptersConceptsHeart failureElectrophysiological substrateSudden cardiac deathCalcium handling proteinsRepolarization gradientsVentricular repolarization heterogeneityHeterogeneous remodelingCardiac deathCardiac functionArrhythmic substrateLeft ventriculeHandling proteinsMuscle layerPathophysiological remodelingRepolarization heterogeneityTissue levelsOrgan system levelArrhythmiasGap junctionsIon channelsOverview of mechanismsSub-cellular changesRemodelingFailureVentriculeUltrastructure and Regulation of Lateralized Connexin43 in the Failing Heart
Hesketh GG, Shah MH, Halperin VL, Cooke CA, Akar FG, Yen TE, Kass DA, Machamer CE, Van Eyk JE, Tomaselli GF. Ultrastructure and Regulation of Lateralized Connexin43 in the Failing Heart. Circulation Research 2010, 106: 1153-1163. PMID: 20167932, PMCID: PMC2896878, DOI: 10.1161/circresaha.108.182147.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutophagyConnexin 43Disease Models, AnimalDogsGap JunctionsHeart FailureHeart VentriclesHeLa CellsHumansMembrane MicrodomainsMicroscopy, ConfocalMicroscopy, Electron, TransmissionMicrotubule-Associated ProteinsMyocardiumPhosphorylationRatsRats, Sprague-DawleyRecombinant Fusion ProteinsTransfectionConceptsGFP-LC3Gap junctionsLateral membranesDistinct phosphorylated formsGap junction turnoverGap junction internalizationForm of LC3Internalized gap junctionsGap junction proteinJunction turnoverSubcellular locationBiochemical regulationCellular pathwaysMultilamellar membrane structuresEndogenous Cx43Phosphorylated formNeonatal rat ventricular myocytesHeLa cellsIntracellular Cx43Membrane structureJunction proteinsCx43ProteinPotential therapeutic implicationsConnexin43