2011
07 Mitochondrial hexokinase II is essential for cardiac function and ischaemic preconditioning
Smeele K, Southworth R, Wu R, Xie C, Nederlof R, Warley A, Koeman A, Eerbeek O, Akar F, Ardehali H, Hollmann M, Zuurbier C. 07 Mitochondrial hexokinase II is essential for cardiac function and ischaemic preconditioning. Heart 2011, 97: e8. DOI: 10.1136/heartjnl-2011-301156.7.Peer-Reviewed Original ResearchIschemic preconditioningCardiac functionWT heartsProtective effectBaseline cardiac functionNormal cardiac functionMitochondrial permeability transition openingContractile impairmentIR injuryReperfusion injuryAcute reductionMyocardial functionGlycolytic enzymes hexokinaseMitochondrial hexokinase-IIEx vivoCardiac contractionMild mitochondrial uncouplingMitochondrial membrane depolarisationMembrane depolarisationHexokinase IIHKIIHeartMitochondrial swellingTissue disruptionInjury
2004
Functional Integration of Electrically Active Cardiac Derivatives From Genetically Engineered Human Embryonic Stem Cells With Quiescent Recipient Ventricular Cardiomyocytes
Xue T, Cho HC, Akar FG, Tsang SY, Jones SP, Marbán E, Tomaselli GF, Li RA. Functional Integration of Electrically Active Cardiac Derivatives From Genetically Engineered Human Embryonic Stem Cells With Quiescent Recipient Ventricular Cardiomyocytes. Circulation 2004, 111: 11-20. PMID: 15611367, DOI: 10.1161/01.cir.0000151313.18547.a2.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAdrenergic beta-AgonistsAnimalsCell DifferentiationCell FusionCells, CulturedDefective VirusesElectrophysiologyFemaleGenes, ReporterGenetic VectorsGiant CellsGreen Fluorescent ProteinsGuinea PigsHeartHeart Conduction SystemHeart VentriclesHIV-1HumansIsoproterenolLidocaineMiceMyocardial ContractionMyocytes, CardiacOrgan Culture TechniquesPericardiumPluripotent Stem CellsPyrimidinesRatsTransduction, GeneticConceptsVentricular cardiomyocytesCardiac impulse generationBeta-adrenergic agonist isoproterenolGuinea pig heartsSite of injectionStem cellsHuman embryonic stem cellsCell-based therapiesContractile activityAgonist isoproterenolPharmacological agentsVentricular myocardiumLeft ventricleEx vivoDonor cardiomyocytesPig heartsHuman cardiomyocytesRecombinant lentivirusMembrane depolarizationCardiomyocytesFunctional syncytiumImpulse generationEmbryonic stem cellsMyocardiumEpicardial surface