2012
GSH or Palmitate Preserves Mitochondrial Energetic/Redox Balance, Preventing Mechanical Dysfunction in Metabolically Challenged Myocytes/Hearts From Type 2 Diabetic Mice
Tocchetti CG, Caceres V, Stanley BA, Xie C, Shi S, Watson WH, O’Rourke B, Spadari-Bratfisch RC, Cortassa S, Akar FG, Paolocci N, Aon MA. GSH or Palmitate Preserves Mitochondrial Energetic/Redox Balance, Preventing Mechanical Dysfunction in Metabolically Challenged Myocytes/Hearts From Type 2 Diabetic Mice. Diabetes 2012, 61: 3094-3105. PMID: 22807033, PMCID: PMC3501888, DOI: 10.2337/db12-0072.Peer-Reviewed Original ResearchConceptsMechanical dysfunctionReactive oxygen speciesType 2 diabetic db/db miceDiabetic db/db miceHigh glucoseType 2 diabetic patientsType 2 diabetic miceDb/db miceLower cardiac performanceLimited exercise capacityPoor glycemic controlType 2 diabetesΒ-agonist isoproterenolCardiac work demandsFatty acid palmitateExercise capacitySympathetic driveGlycemic controlDiabetic patientsDiabetic miceDb miceHeart dysfunctionPatient's inabilityMitochondrial reactive oxygen speciesHeart preparation
2011
Alterations in Mitochondrial State 4→3 Transition Underlie Stress-Induced Energetic-Redox Imbalance and Myocyte Dysfunction in Diabetic Mice
Tocchetti C, Stanley B, Shi S, Watson W, Cortassa S, Akar F, Paolocci N, Aon M. Alterations in Mitochondrial State 4→3 Transition Underlie Stress-Induced Energetic-Redox Imbalance and Myocyte Dysfunction in Diabetic Mice. Biophysical Journal 2011, 100: 292a. DOI: 10.1016/j.bpj.2010.12.1795.Peer-Reviewed Original Research