2015
LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation
Kim GE, Ross JL, Xie C, Su KN, Zaha VG, Wu X, Palmeri M, Ashraf M, Akar JG, Russell KS, Akar FG, Young LH. LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation. Cardiovascular Research 2015, 108: 197-208. PMID: 26378152, PMCID: PMC4571838, DOI: 10.1093/cvr/cvv212.Peer-Reviewed Original ResearchConceptsLiver kinase B1Protein kinaseLKB1 deletionMetabolic regulator AMPAtrial fibrillationChannel expressionMHC-CreElectrophysiological functionKnockout mouse modelRelated kinasesLKB1 pathwayGene expressionPerpetuation of AFKinase B1Neonatal atrial myocytesΑMHC-CreKinasePostnatal day 1Patch-clamp recordingsAtrial growthWeeks of ageDeletionSodium current densityAction potential generationSpecific role
2008
Targeted deletion of kcne2 impairs ventricular repolarization via disruption of IK,slow1 and Ito,f
Roepke TK, Kontogeorgis A, Ovanez C, Xu X, Young JB, Purtell K, Goldstein PA, Christini DJ, Peters NS, Akar FG, Gutstein DE, Lerner DJ, Abbott GW. Targeted deletion of kcne2 impairs ventricular repolarization via disruption of IK,slow1 and Ito,f. The FASEB Journal 2008, 22: 3648-3660. PMID: 18603586, PMCID: PMC2537427, DOI: 10.1096/fj.08-110171.Peer-Reviewed Original ResearchConceptsAlpha subunitKv4 alpha subunitsAction potential durationVentricular action potential durationFunctional promiscuityVentricular membrane fractionsLong QT syndromeVentricular repolarizationAncillary subunitsWild typeNovel roleMembrane fractionKcne2 deletionKv1.5 proteinTargeted deletionSubunitsKcne2 disruptionMiRP1Cardiac roleProteinKCNE2DeletionKv1.5Sevoflurane anesthesiaDisruption