Mitochondrial Ion Channels in Cardiac Function and Dysfunction
O'Rourke B, Cortassa S, Akar F, Aon M. Mitochondrial Ion Channels in Cardiac Function and Dysfunction. Novartis Foundation Symposia 2007, 287: 140-156. PMID: 18074636, PMCID: PMC2692520, DOI: 10.1002/9780470725207.ch10.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMitochondrial ion channelsIon channelsReactive oxygen species (ROS) signalsNumerous signaling pathwaysBurst of ROSMitochondrial networkMitochondrial physiologyPlasma membraneSpecies signalSignaling pathwaysCellular activitiesCellular targetsMitochondrial functionEnergy transductionMitochondriaVast modificationsPhysiological conditionsOrgan levelDisease developmentPotential therapeutic interventionsWidespread effectsImportant targetSurprising insightsKey roleCenter of organizations