Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy
Khoshkhoo S, Wang Y, Chahine Y, Erson-Omay E, Robert S, Kiziltug E, Damisah E, Nelson-Williams C, Zhu G, Kong W, Huang A, Stronge E, Phillips H, Chhouk B, Bizzotto S, Chen M, Adikari T, Ye Z, Witkowski T, Lai D, Lee N, Lokan J, Scheffer I, Berkovic S, Haider S, Hildebrand M, Yang E, Gunel M, Lifton R, Richardson R, Blümcke I, Alexandrescu S, Huttner A, Heinzen E, Zhu J, Poduri A, DeLanerolle N, Spencer D, Lee E, Walsh C, Kahle K. Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy. JAMA Neurology 2023, 80: 578-587. PMID: 37126322, PMCID: PMC10152377, DOI: 10.1001/jamaneurol.2023.0473.Peer-Reviewed Original ResearchConceptsDrug-resistant mesial temporal lobe epilepsyMesial temporal lobe epilepsyPathogenic somatic variantsTemporal lobe epilepsyMedian ageLobe epilepsyTemporal neocortexHippocampal tissueLevel 4 epilepsy centerAvailable frozen tissueSomatic variantsControl brain tissueMedial temporal lobectomyNew therapeutic targetsMolecular assaysGene panel sequencingRas/Raf/MAPK signalingAntiseizure medicationsMost patientsCommon indicationGermline genetic variantsEpilepsy centersTemporal lobectomyEpilepsy surgerySex-matched neurotypical controlsRecent advances in epilepsy surgery
Medina-Pizarro M, Spencer D, Damisah E. Recent advances in epilepsy surgery. Current Opinion In Neurology 2023, 36: 95-101. PMID: 36762633, DOI: 10.1097/wco.0000000000001134.Peer-Reviewed Original ResearchConceptsEpilepsy surgeryEpilepsy centersComprehensive Epilepsy CenterDrug-resistant epilepsySurgical outcome dataReasonable surgical alternativeAdequate trialAntiseizure medicationsPreoperative evaluationSurgical candidacySurgical outcomesSeizure networkSurgical alternativeEpileptogenic networksSurgical techniqueTreatment strategiesEpileptogenic regionInvasive techniquesOutcome dataSurgeryDepth electrodesHigh-resolution structural imagingSubtle abnormalitiesDiagnostic toolStructural imaging