2004
Exchange of DNA Base Pairs that Coincides with Recognition of Homology Promoted by E. coli RecA Protein
Folta-Stogniew E, O'Malley S, Gupta R, Anderson KS, Radding CM. Exchange of DNA Base Pairs that Coincides with Recognition of Homology Promoted by E. coli RecA Protein. Molecular Cell 2004, 15: 965-975. PMID: 15383285, DOI: 10.1016/j.molcel.2004.08.017.Peer-Reviewed Original ResearchConceptsE. coli RecA proteinRecognition of homologyColi RecA proteinRecA proteinBase pairsStrand exchangeSynaptic complexDouble-strand breaksT base pairsStopped-flow fluorescenceGenetic recombinationSingle strandsHomologyUnresolved mechanismDuplex DNADNA base pairsDNARate of exchangeProteinDynamic structureComplexesStrandsBasis exchangeRate of formationMechanism
1999
Rapid Exchange of A:T Base Pairs Is Essential for Recognition of DNA Homology by Human Rad51 Recombination Protein
Gupta R, Folta-Stogniew E, O'Malley S, Takahashi M, Radding C. Rapid Exchange of A:T Base Pairs Is Essential for Recognition of DNA Homology by Human Rad51 Recombination Protein. Molecular Cell 1999, 4: 705-714. PMID: 10619018, DOI: 10.1016/s1097-2765(00)80381-0.Peer-Reviewed Original ResearchConceptsRecognition of homologyBase pairsRad51 recombination proteinT base pairsRecombination proteinsHuman Rad51Genetic exchangeFluorescence resonance energy transferUbiquitous familyMechanism of recognitionDNA repairStrand exchangeDNA homologyBase substitutionsHomologyResonance energy transferDuplex DNAHelix destabilizationCritical roleBase mismatchesProteinSingle strandsRAD51Rapid exchangeKinetic analysisHuman Rad51 Protein Can Form Homologous Joints in the Absence of Net Strand Exchange*
Gupta R, Folta-Stogniew E, Radding C. Human Rad51 Protein Can Form Homologous Joints in the Absence of Net Strand Exchange*. Journal Of Biological Chemistry 1999, 274: 1248-1256. PMID: 9880493, DOI: 10.1074/jbc.274.3.1248.Peer-Reviewed Original ResearchConceptsStrand exchangeRecA proteinEscherichia coli RecA proteinColi RecA proteinHuman Rad51 proteinDNA strand exchange reactionStrand exchange reactionEukaryotic homologsHsRad51 proteinRad51 proteinHomologous pairingGC contentCentral enzymeHeteroduplex DNABiological roleHsRad51Oligonucleotide substratesRich DNAGC compositionHuman DNAProteinLinear duplexHomologous jointsDNAGC pairs
1997
RecA tests homology at both pairing and strand exchange
Bazemore L, Folta-Stogniew E, Takahashi M, Radding C. RecA tests homology at both pairing and strand exchange. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 11863-11868. PMID: 9342328, PMCID: PMC23638, DOI: 10.1073/pnas.94.22.11863.Peer-Reviewed Original Research