Featured Publications
A phenomapping-derived tool to personalize the selection of anatomical vs. functional testing in evaluating chest pain (ASSIST)
Oikonomou EK, Van Dijk D, Parise H, Suchard MA, de Lemos J, Antoniades C, Velazquez EJ, Miller EJ, Khera R. A phenomapping-derived tool to personalize the selection of anatomical vs. functional testing in evaluating chest pain (ASSIST). European Heart Journal 2021, 42: 2536-2548. PMID: 33881513, PMCID: PMC8488385, DOI: 10.1093/eurheartj/ehab223.Peer-Reviewed Original ResearchConceptsStable chest painChest painPrimary endpointMajor adverse cardiovascular eventsNon-fatal myocardial infarctionAdverse cardiovascular eventsStudy's primary endpointCoronary artery diseaseClinical trial populationsCox regression modelParticipant-level dataSCOT-HEARTCardiovascular eventsCause mortalityHazard ratioPatients 5Artery diseaseFunctional testingPROMISE trialTrial populationMyocardial infarctionLower incidenceStudy populationPainCollected variables
2024
Real-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort study
Oikonomou E, Aminorroaya A, Dhingra L, Partridge C, Velazquez E, Desai N, Krumholz H, Miller E, Khera R. Real-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort study. European Heart Journal - Digital Health 2024, 5: 303-313. PMID: 38774380, PMCID: PMC11104476, DOI: 10.1093/ehjdh/ztae023.Peer-Reviewed Original ResearchRisk of acute myocardial infarctionAssociated with lower oddsHospital health systemCoronary artery diseaseCardiac testingRisk of adverse outcomesUK BiobankHealth systemProvider-drivenLower oddsAssociated with better outcomesAcute myocardial infarctionBlack raceStable chest painFemale sexReal world evaluationDiabetes historyMulticohort studyFunction testsSuspected coronary artery diseaseYounger ageRisk profileAdverse outcomesMultinational cohortPost hoc analysis
2020
Real world cost and health outcomes of patients presented with chest pain in England: which is the most cost-effective first-line test?
Tsiachristas A, West H, Oikonomou E, Mihaylova B, Sabharwall N, Channon K, Neubauer S, Antoniades C. Real world cost and health outcomes of patients presented with chest pain in England: which is the most cost-effective first-line test? European Heart Journal 2020, 41: ehaa946.3547. DOI: 10.1093/ehjci/ehaa946.3547.Peer-Reviewed Original ResearchStable chest painFirst-line diagnostic testChest painClinical presentationNICE guidelinesDiagnostic testsClinical pathwayHealth Research Oxford Biomedical Research CentreStandardised ratesHealth outcomesReal-world clinical settingNon-invasive diagnostic testsChest pain clinicClass I indicationsRecent ESC guidelinesProportion of patientsManagement of patientsTomography coronary angiographyFirst-line investigationSubsequent diagnostic testsCurrent clinical pathwaysNational InstituteFirst-line diagnosticsFirst-line testClinical decision process