Featured Publications
A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography
Oikonomou EK, Williams MC, Kotanidis CP, Desai MY, Marwan M, Antonopoulos AS, Thomas KE, Thomas S, Akoumianakis I, Fan LM, Kesavan S, Herdman L, Alashi A, Centeno EH, Lyasheva M, Griffin BP, Flamm SD, Shirodaria C, Sabharwal N, Kelion A, Dweck MR, Van Beek EJR, Deanfield J, Hopewell JC, Neubauer S, Channon KM, Achenbach S, Newby DE, Antoniades C. A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. European Heart Journal 2019, 40: 3529-3543. PMID: 31504423, PMCID: PMC6855141, DOI: 10.1093/eurheartj/ehz592.Peer-Reviewed Original ResearchConceptsPerivascular adipose tissueFat attenuation indexCoronary CT angiographyCardiac risk predictionCoronary perivascular adipose tissueMajor adverse cardiac eventsCT angiographyRisk predictionHigh-risk plaque featuresPerivascular fat attenuation indexRadiomic featuresAdverse cardiac eventsConsecutive eligible participantsSCOT-HEART trialTraditional risk stratificationCoronary artery diseaseCoronary calcium scoreStandard coronary CT angiographyAcute myocardial infarctionCoronary inflammationCardiac eventsArtery diseaseCalcium scoreCardiac surgeryMACE prediction
2020
Pericoronary fat radiomic profile (FRP) predicts long-term cardiac risk in individuals with calcium score below 100 on coronary computed tomography angiography
Kotanidis C, Oikonomou E, Williams M, Thomas S, Thomas K, Lyasheva M, Antonopoulos A, Dweck M, Shirodaria C, Neubauer S, Channon K, Newby D, Antoniades C. Pericoronary fat radiomic profile (FRP) predicts long-term cardiac risk in individuals with calcium score below 100 on coronary computed tomography angiography. European Heart Journal 2020, 41: ehaa946.0181. DOI: 10.1093/ehjci/ehaa946.0181.Peer-Reviewed Original ResearchCoronary artery calciumCoronary artery diseaseHigh-risk plaquesAdipose tissue compositionArtery calciumCAC scoreCardiac riskTomography angiographyStudy populationLong-term cardiac riskMajor adverse cardiac eventsObstructive coronary artery diseaseSCOT-HEART trialAdverse cardiac eventsRisk of MACEAdverse clinical eventsTraditional risk factorsChronic vascular inflammationLow CAC scoresPericoronary adipose tissueCardiovascular risk assessmentLow-risk populationCox regression modelBritish Heart FoundationBiomedical Research CentreOP3 Improved cardiac risk stratification in individuals with high risk plaque features using the perivascular fat attenuation index on CCTA
Kotanidis C, Oikonomou E, Marwan M, Kluener L, Thomas K, Alashi A, Antonopoulos A, Shirodaria C, Neubauer S, Channon K, Achenbach S, Desai M, Antoniades C. OP3 Improved cardiac risk stratification in individuals with high risk plaque features using the perivascular fat attenuation index on CCTA. Heart 2020, 106: a1-a2. DOI: 10.1136/heartjnl-2020-bsci.3.Peer-Reviewed Original ResearchFat attenuation indexHigh-risk plaquesPerivascular fat attenuation indexAdjusted riskCardiac riskHRP featuresHigh-risk plaque featuresMajor adverse cardiac eventsProximal right coronary arteryAdditive predictive valueAdverse cardiac eventsLow-attenuation plaqueRight coronary arteryCardiac risk stratificationCox regression modelNapkin-ring signAdipose tissue compositionCoronary inflammationCardiac mortalityInflammatory burdenCardiac eventsSpotty calcificationRisk stratificationPlaque featuresCoronary artery