Featured Publications
A phenomapping-derived tool to personalize the selection of anatomical vs. functional testing in evaluating chest pain (ASSIST)
Oikonomou EK, Van Dijk D, Parise H, Suchard MA, de Lemos J, Antoniades C, Velazquez EJ, Miller EJ, Khera R. A phenomapping-derived tool to personalize the selection of anatomical vs. functional testing in evaluating chest pain (ASSIST). European Heart Journal 2021, 42: 2536-2548. PMID: 33881513, PMCID: PMC8488385, DOI: 10.1093/eurheartj/ehab223.Peer-Reviewed Original ResearchConceptsStable chest painChest painPrimary endpointMajor adverse cardiovascular eventsNon-fatal myocardial infarctionAdverse cardiovascular eventsStudy's primary endpointCoronary artery diseaseClinical trial populationsCox regression modelParticipant-level dataSCOT-HEARTCardiovascular eventsCause mortalityHazard ratioPatients 5Artery diseaseFunctional testingPROMISE trialTrial populationMyocardial infarctionLower incidenceStudy populationPainCollected variablesA novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography
Oikonomou EK, Williams MC, Kotanidis CP, Desai MY, Marwan M, Antonopoulos AS, Thomas KE, Thomas S, Akoumianakis I, Fan LM, Kesavan S, Herdman L, Alashi A, Centeno EH, Lyasheva M, Griffin BP, Flamm SD, Shirodaria C, Sabharwal N, Kelion A, Dweck MR, Van Beek EJR, Deanfield J, Hopewell JC, Neubauer S, Channon KM, Achenbach S, Newby DE, Antoniades C. A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. European Heart Journal 2019, 40: 3529-3543. PMID: 31504423, PMCID: PMC6855141, DOI: 10.1093/eurheartj/ehz592.Peer-Reviewed Original ResearchConceptsPerivascular adipose tissueFat attenuation indexCoronary CT angiographyCardiac risk predictionCoronary perivascular adipose tissueMajor adverse cardiac eventsCT angiographyRisk predictionHigh-risk plaque featuresPerivascular fat attenuation indexRadiomic featuresAdverse cardiac eventsConsecutive eligible participantsSCOT-HEART trialTraditional risk stratificationCoronary artery diseaseCoronary calcium scoreStandard coronary CT angiographyAcute myocardial infarctionCoronary inflammationCardiac eventsArtery diseaseCalcium scoreCardiac surgeryMACE prediction
2023
MECHANISTIC EVALUATION OF AN AI-DRIVEN CLINICAL DECISION SUPPORT TOOL TO PERSONALIZE THE USE OF ANATOMICAL TESTING IN SUSPECTED CORONARY ARTERY DISEASE
Oikonomou E, Suchard M, Miller E, Velazquez E, Khera R. MECHANISTIC EVALUATION OF AN AI-DRIVEN CLINICAL DECISION SUPPORT TOOL TO PERSONALIZE THE USE OF ANATOMICAL TESTING IN SUSPECTED CORONARY ARTERY DISEASE. Journal Of The American College Of Cardiology 2023, 81: 1360. DOI: 10.1016/s0735-1097(23)01804-1.Peer-Reviewed Original Research
2019
Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases
Akoumianakis I, Sanna F, Margaritis M, Badi I, Akawi N, Herdman L, Coutinho P, Fagan H, Antonopoulos AS, Oikonomou EK, Thomas S, Chiu AP, Chuaiphichai S, Kotanidis CP, Christodoulides C, Petrou M, Krasopoulos G, Sayeed R, Lv L, Hale A, Naeimi Kararoudi M, McNeill E, Douglas G, George S, Tousoulis D, Channon KM, Antoniades C. Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases. Science Translational Medicine 2019, 11 PMID: 31534019, PMCID: PMC7212031, DOI: 10.1126/scitranslmed.aav5055.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdipose TissueAnimalsArteriesAtherosclerosisBlood VesselsCell MovementEndopeptidasesEnzyme ActivationLigandsMice, Inbred C57BLMuscle, Smooth, VascularMyocytes, Smooth MuscleNADPH OxidasesObesityOxidantsOxidation-ReductionRac1 GTP-Binding ProteinSignal TransductionVascular DiseasesWnt-5a ProteinConceptsAdipose tissueArterial wallFrizzled-related protein 5Oxidative stressArterial oxidative stressVascular disease pathogenesisNADPH oxidaseCoronary plaque progressionCoronary artery diseaseVascular oxidative stressVascular smooth muscle cellsFrizzled-2Smooth muscle cellsVascular redoxArtery diseaseHuman arterial wallPlasma concentrationsPlaque progressionParacrine mechanismsObesityParacrine effectsDisease pathogenesisMuscle cellsTranslational implicationsVascular signalingCardiac Computed Tomography
Oikonomou EK, West HW, Antoniades C. Cardiac Computed Tomography. Arteriosclerosis Thrombosis And Vascular Biology 2019, 39: 2207-2219. PMID: 31510795, DOI: 10.1161/atvbaha.119.312899.Peer-Reviewed Original ResearchConceptsCardiac computed tomographyComputed tomographyCoronary atherosclerosisCoronary plaque burdenAcute coronary syndromeCoronary artery diseaseFirst-line diagnostic testUnstable coronary plaquesMorphological plaque featuresCoronary syndromeInflammatory burdenArterial inflammationArtery diseaseCoronary lesionsPlaque burdenPlaque featuresPrognostic implicationsCoronary plaquesPerivascular fatHemodynamic significanceVulnerable plaquesDiagnostic testsMajor causeTomographyCurrent role
2017
Detecting human coronary inflammation by imaging perivascular fat
Antonopoulos AS, Sanna F, Sabharwal N, Thomas S, Oikonomou EK, Herdman L, Margaritis M, Shirodaria C, Kampoli AM, Akoumianakis I, Petrou M, Sayeed R, Krasopoulos G, Psarros C, Ciccone P, Brophy CM, Digby J, Kelion A, Uberoi R, Anthony S, Alexopoulos N, Tousoulis D, Achenbach S, Neubauer S, Channon KM, Antoniades C. Detecting human coronary inflammation by imaging perivascular fat. Science Translational Medicine 2017, 9 PMID: 28701474, DOI: 10.1126/scitranslmed.aal2658.Peer-Reviewed Original ResearchConceptsPerivascular adipose tissueFat attenuation indexVascular inflammationSubclinical coronary artery diseaseHuman adipose tissue explantsHuman vesselsLipid accumulationHuman coronary vasculatureAcute coronary syndromeCoronary artery diseaseVulnerable atherosclerotic plaquesIntracellular lipid accumulationHuman coronary arteriesAdipocyte lipid contentAdipose tissue explantsPositron emission tomographyCT scan informationCoronary inflammationCoronary syndromeArtery diseaseCardiac surgeryValidation cohortCoronary arteryMultiple disease statesTissue inflammation