2024
Acute stress increases striatal connectivity with cortical regions enriched for μ- and κ-opioid receptors
Zhukovsky P, Ironside M, Duda J, Moser A, Null K, Dhaynaut M, Normandin M, Guehl N, El Fakhri G, Alexander M, Holsen L, Misra M, Narendran R, Hoye J, Morris E, Esfand S, Goldstein J, Pizzagalli D. Acute stress increases striatal connectivity with cortical regions enriched for μ- and κ-opioid receptors. Biological Psychiatry 2024 PMID: 38395372, DOI: 10.1016/j.biopsych.2024.02.005.Peer-Reviewed Original ResearchMajor depressive disorderFunctional connectivityEffects of stressAcute stressK-opioid receptorsStriatal connectivityEtiology of major depressive disorderCortical regionsMontreal Imaging Stress TaskEffects of acute stressGlobal FCIncreased striatal connectivityVentral attention/salience networkAllen Human Brain AtlasDefault mode networkCortical connectivityHuman Brain AtlasMDD studiesDepressive disorderFrontoparietal networkNeurobiological effectsMode networkStress taskDimensional approachMDD riskIntense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson’s disease
de Laat B, Hoye J, Stanley G, Hespeler M, Ligi J, Mohan V, Wooten D, Zhang X, Nguyen T, Key J, Colonna G, Huang Y, Nabulsi N, Patel A, Matuskey D, Morris E, Tinaz S. Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson’s disease. Npj Parkinson's Disease 2024, 10: 34. PMID: 38336768, PMCID: PMC10858031, DOI: 10.1038/s41531-024-00641-1.Peer-Reviewed Original ResearchDopamine transporterSubstantia nigraDopaminergic neuronsDopamine transporter availabilityNeuroprotective effects of exerciseDopaminergic systemClinical progression of PDEarly PDSubstantiaNeuromelanin contentNigraLoss of dopaminergic neuronsEffects of exerciseNM-MRIDopamineSystem of patientsProgressive loss of dopaminergic neuronsParkinson's diseaseClinical progressionProgression of PDNeuroprotective effectsClinical trialsIntensity exercisePET imagingProgressive loss
2023
SLIC-Occ: functional segmentation of occupancy images improves precision of EC50 images
Ibrahimy A, Hoye J, Wu H, de Laat B, Kim S, Wilson D, Morris E. SLIC-Occ: functional segmentation of occupancy images improves precision of EC50 images. EJNMMI Physics 2023, 10: 80. PMID: 38079001, PMCID: PMC10713928, DOI: 10.1186/s40658-023-00600-4.Peer-Reviewed Original ResearchMeasuring Heart Rate Accurately in Patients With Parkinson Disease During Intense Exercise: Usability Study of Fitbit Charge 4
Colonna G, Hoye J, de Laat B, Stanley G, Ibrahimy A, Tinaz S, Morris E. Measuring Heart Rate Accurately in Patients With Parkinson Disease During Intense Exercise: Usability Study of Fitbit Charge 4. JMIR Biomedical Engineering 2023, 8: e51515. PMID: 38875680, PMCID: PMC11041416, DOI: 10.2196/51515.Peer-Reviewed Original ResearchTheoretical maximum heart rateHeart rateParkinson's diseaseExercise sessionsIntense exerciseExercise programExercise intensityHigh-intensity exercise sessionsEarly-stage Parkinson's diseaseIntensive exercise programAerobic physical exerciseCohort of patientsBackground Parkinson’s diseaseRole of exerciseHigh-intensity exerciseCommon neurodegenerative diseaseMean heart rateMaximum heart rateHR monitorAverage heart rateR interval measurementRecent pilot studyPolar H10Nonmotor symptomsClinical cohort