2024
Associations Between Reductions in Depressive Symptoms and Reductions in Pain and Anxiety Symptoms and Substance Use: Emulation of a Randomized Trial
Khan M, Acri M, Ban K, Scheidell J, Stevens E, Manandhar-Sasaki P, Charles D, Chichetto N, Crystal S, Gordon A, Marshall B, Edelman E, Justice A, Braithwaite S, Caniglia E. Associations Between Reductions in Depressive Symptoms and Reductions in Pain and Anxiety Symptoms and Substance Use: Emulation of a Randomized Trial. AJPM Focus 2024, 3: 100258. PMID: 39290574, PMCID: PMC11407062, DOI: 10.1016/j.focus.2024.100258.Peer-Reviewed Original ResearchUnhealthy alcohol useDepressive symptomsAnxiety symptomsIllicit opioid useOdds ratioAlcohol useVeterans Aging Cohort StudyPain symptomsConfidence intervalsTarget trial emulation frameworkElevated depressive symptomsAssociated with reductionsReducing depressive symptomsAging Cohort StudySubstance useOpioid useMultisite observational studyDepressive symptom reductionNext follow-up visitUS veteransReduce painFollow-up visitCohort studyAntidepressant medicationComparing individuals
2022
Cessation of self-reported opioid use and impacts on co-occurring health conditions
Scheidell J, Townsend T, Ban K, Caniglia E, Charles D, Edelman E, Marshall B, Gordon A, Justice A, Braithwaite R, Khan M. Cessation of self-reported opioid use and impacts on co-occurring health conditions. Drug And Alcohol Dependence 2022, 242: 109712. PMID: 36469994, PMCID: PMC10108375, DOI: 10.1016/j.drugalcdep.2022.109712.Peer-Reviewed Original ResearchConceptsOpioid useCocaine useSelf-reported opioid useBaseline opioid useCo-occurring health conditionsUnhealthy alcohol useEvidence-based interventionsLogistic regression modelsOpioid misusePrescription opioidsSelf-reported useReporting cannabisDepressive symptomsPainCannabis useAlcohol useHealth conditionsSubstance useSymptomsAnxiety symptomsSubsequent cessationCessationRegression modelsOutcomesParticipants