2024
Maternal immune response during pregnancy and neurodevelopmental outcomes: A longitudinal approach
Euclydes V, Braga C, Gouveia G, Martinez R, Camilo C, Simões S, Martins-Jr D, Fracolli L, Argeu A, Ferraro A, Matijasevich A, Fatori D, Miguel E, Polanczyk G, Brentani H. Maternal immune response during pregnancy and neurodevelopmental outcomes: A longitudinal approach. Brain Behavior & Immunity - Health 2024, 40: 100832. DOI: 10.1016/j.bbih.2024.100832.Peer-Reviewed Original ResearchMaternal immune responseTrimester of pregnancyImmune responseNeurodevelopmental outcomesImmunological markersImmunological biomarkersMaternal childhood traumaNeurodevelopmental trajectoriesMother's immune responseEarly stages of pregnancyWeeks of pregnancyMaternal psychosocial stressStages of pregnancyStages of gestationRandomized clinical trialsAnti-inflammatory stateMaternal stress experienceNeurodevelopmental scoresImmune system responseInflammatory biomarkersClinical trialsPregnancyPsychosocial stress conditionBlood samplesLinear mixed-effects modelsThe trajectory of anxiety symptoms during the transition from childhood to young adulthood is predicted by IQ and sex, but not polygenic risk scores
Salto A, Salum G, Hoffmann M, Santoro M, Zugman A, Pan P, Belangero S, Ito L, Doretto V, Croci M, Brañas M, de Giusti C, Da Silva‐Jr F, Ribeiro S, Miguel E, Leckman J. The trajectory of anxiety symptoms during the transition from childhood to young adulthood is predicted by IQ and sex, but not polygenic risk scores. JCPP Advances 2024 DOI: 10.1002/jcv2.12268.Peer-Reviewed Original ResearchAnxiety symptomsIntelligence quotientTrajectory class membershipPolygenic risk scoresTrajectory classesLate adolescenceCourse of anxiety symptomsScreen for Child Anxiety Related DisordersTrajectories of anxiety symptomsBrazilian High-Risk CohortYoung adulthoodEffect of intelligence quotientAnxiety related disordersHigh-decreasing classClass membershipLongitudinal studyConfirmatory factor analysisGrowth mixture modelingIncidence of anxiety symptomsInternalizing symptomatologyLow-increasing classHigher IQCognitive abilitiesAnxiety riskFactor analysisGPT-based normative models of brain sMRI correlate with dimensional psychopathology
Mendes S, Pinaya W, Pan P, Gadelha A, Belangero S, Jackowski A, Rohde L, Miguel E, Sato J. GPT-based normative models of brain sMRI correlate with dimensional psychopathology. Imaging Neuroscience 2024, 2: 1-15. DOI: 10.1162/imag_a_00204.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderChild Behavior ChecklistDeficit hyperactivity disorderAutism spectrum disorderPsychiatric disordersBrain regionsStructural MRIDimensional psychopathologyHyperactivity disorderBrazilian High-Risk Cohort StudyAttention deficit hyperactivity disorder scoresAutism Brain Imaging Data Exchange IIAdolescent Brain Cognitive DevelopmentChild Behavior Checklist scalesHigh Risk Cohort StudyDetect psychiatric symptomsEmergent psychiatric disordersBrain structural MRINeurobiological substratesNeuroimaging studiesLanguage tasksPsychiatric symptomsBehavior ChecklistPsychiatric conditionsSpectrum disorderIs waiting for rewards good for you? No association between impulsive choice, psychopathology, and functional outcomes in a large cohort sample
Bado P, Salum G, Rohde L, Gadelha A, Pan P, Miguel E, Tripp G, Furukawa E. Is waiting for rewards good for you? No association between impulsive choice, psychopathology, and functional outcomes in a large cohort sample. JCPP Advances 2024, 4: e12231. PMID: 38827985, PMCID: PMC11143955, DOI: 10.1002/jcv2.12231.Peer-Reviewed Original ResearchDelayed rewardsPsychiatric conditionsPresence of psychiatric disordersLife outcomesBaseline task performanceImpulsive choicePositive long-term outcomesImmediate rewardsPsychiatric disordersTask performanceADHDResults ChildrenRewardChildren's preferencesStronger preferenceSchool-based cohortDisordersLongitudinal outcomesCohort sampleFunctional outcomesChildrenCohort of Brazilian childrenBrazilian childrenPsychopathologyDiverse populationsAn evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis
Ramakrishnan D, Farhat L, Vattimo E, Levine J, Johnson J, Artukoglu B, Landeros-Weisenberger A, Zangen A, Pelissolo A, de B Pereira C, Rück C, Costa D, Mataix-Cols D, Shannahoff-Khalsa D, Tolin D, Zarean E, Meyer E, Hawken E, Storch E, Andersson E, Miguel E, Maina G, Leckman J, Sarris J, March J, Diniz J, Kobak K, Mallet L, Vulink N, Amiaz R, Fernandes R, Shavitt R, Wilhelm S, Golshan S, Tezenas du Montcel S, Erzegovesi S, Baruah U, Greenberg W, Kobayashi Y, Bloch M. An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis. Journal Of Psychiatric Research 2024, 173: 387-397. PMID: 38598877, DOI: 10.1016/j.jpsychires.2024.03.044.Peer-Reviewed Original ResearchConceptsYale-Brown Obsessive-Compulsive ScaleObsessive-compulsive disorderCGI-IRandomized-controlled trialsAdult obsessive-compulsive disorderClinical Global Impression ImprovementObsessive-Compulsive ScaleTreatment responseIndividual-patient data meta-analysisPosttreatment scoresEvaluation of treatment responseMeta-analysis of randomized-controlled trialsFirst-line therapyCGIIndividual participant dataMeta-analysisNovel treatment modalitiesExpert consensusIndividual participant data meta-analysisSystematic reviewDisordersData meta-analysisPosttreatmentRemission definitionsImpressive improvementCausal Pathways Between the Acute Experience of Violence During Pregnancy and Fetal Intrauterine Growth Restriction: A Cohort Study
Blumrich L, Silva L, Barreto V, Rohde L, Polanczyk G, Miguel E, Grisi S, Fleitlich-Bilyk B, Ferraro A. Causal Pathways Between the Acute Experience of Violence During Pregnancy and Fetal Intrauterine Growth Restriction: A Cohort Study. Journal Of Women's Health 2024, 33: 765-773. PMID: 38551182, DOI: 10.1089/jwh.2023.0645.Peer-Reviewed Original ResearchIntrauterine growth restrictionAssociated with intrauterine growth restrictionGrowth restrictionProspective population-based birth cohortCausal pathwaysFetal intrauterine growth restrictionPopulation-based birth cohortExperiences of violenceNegative health consequencesAcute experimentsHealth consequences of violenceEmergency careGestational depressionGestational trimesterLow birthweightBirth cohortAlcohol consumptionCohort studyBlood pressurePregnancyConsequences of violencePath analysis modelMediation analysisCohortAdequate fitIncreases in functional connectivity between the default mode network and sensorimotor network correlate with symptomatic improvement after transcranial direct current stimulation for obsessive-compulsive disorder
Echevarria M, Batistuzzo M, Silva R, Brunoni A, Sato J, Miguel E, Hoexter M, Shavitt R. Increases in functional connectivity between the default mode network and sensorimotor network correlate with symptomatic improvement after transcranial direct current stimulation for obsessive-compulsive disorder. Journal Of Affective Disorders 2024, 355: 175-183. PMID: 38548207, DOI: 10.1016/j.jad.2024.03.141.Peer-Reviewed Original ResearchTranscranial direct current stimulationObsessive-compulsive disorderDirect current stimulationCurrent stimulationActive transcranial direct current stimulationSensorimotor networkOCD symptom dimensionsTreatment-resistant obsessive-compulsive disorderNeurobiological mechanisms of actionObsessive-compulsive disorder pathophysiologyWhole-brain connectivity analysisDaily tDCS sessionsSymptom improvementResting-state functional MRITDCS sessionsNon-invasive neuromodulation interventionsBrain stimulation interventionsFunctional connectivity changesAssociated with connectivityLeft deltoidSymptom dimensionsNeurobiological mechanismsLeft precuneusMode networkPre/postcentral gyriPerinatal and neonatal factors and mental disorders in children and adolescents: looking for the contributions of the early environment to common and dissociable aspects of psychopathology
Leusin F, Damiano R, Mendes L, Hoffmann M, Manfro A, Pan P, Gadelha A, de Jesus Mari J, Manfro G, Miguel E, Rohde L, Bressan R, Salum G. Perinatal and neonatal factors and mental disorders in children and adolescents: looking for the contributions of the early environment to common and dissociable aspects of psychopathology. European Child & Adolescent Psychiatry 2024, 1-11. PMID: 38519607, DOI: 10.1007/s00787-024-02402-0.Peer-Reviewed Original ResearchMental disordersPsychiatric disordersCo-occurrence of mental disordersPresence of mental disordersDomains of psychopathologyYears of age childrenModel psychiatric disordersPsychiatric disorder diagnosisOverall psychopathologyBifactor modelDisorder diagnosisPsychopathologyBehavioral assessmentP-factorEarly environmentLow level of maternal educationLevel of maternal educationLow socioeconomic statusDisordersNeonatal factorsPrimary caregiversAge childrenAssociated with male sexSocioeconomic statusMaternal educationPost-COVID-19 condition: systemic inflammation and low functional exercise capacity
de Castro G, Gama L, Ramos A, da Silva G, de Souza Teixeira A, Cunha-Neto E, de Souza H, Marie S, Talib L, Coelho V, Kalil J, de Araujo A, Ritto A, Belon A, Santos A, Barrére A, Sawamura M, Lamas C, Baldi B, Carvalho C, Kulikowski L, Damiano R, Imamura M, Neto J, Lira F, Otoch J, Miguel E, Battistella L, Forlenza O, Busatto G, Seelaender M. Post-COVID-19 condition: systemic inflammation and low functional exercise capacity. Frontiers In Nutrition 2024, 11: 1295026. PMID: 38549752, PMCID: PMC10973152, DOI: 10.3389/fnut.2024.1295026.Peer-Reviewed Original ResearchPost-COVID-19 conditionTimed Up and Go testUp-and-go testPhysical performance testsAcute COVID-19Low handgrip strengthFollow-up assessment 6Cross-sectional studySelf-reported symptomsFollow-up assessmentQuality of lifeDiagnosing pulmonary lesionsHandgrip strengthSerum cytokine profilesSerum cytokine levelsImpact of inflammationControl groupMCP-1 levelsIL-4 concentrationMale participantsHospital dischargeSymptom questionnaireSymptom groupsFemale participantsDebilitating symptomsFacing the Unknown: An Inductive Analysis of the Lived Experience of Medical Residents during the COVID-19 Pandemic
Guimarães-Fernandes F, Benoit L, de Oliveira L, Neto P, Feniman D, Correia A, de Oliveira Bosoni N, Macaya D, Miguel E, Ceron-Litvoc D, Castellana G. Facing the Unknown: An Inductive Analysis of the Lived Experience of Medical Residents during the COVID-19 Pandemic. Psychopathology 2024, 57: 169-181. PMID: 38467115, DOI: 10.1159/000536135.Peer-Reviewed Original ResearchMedical residentsHealthcare professionalsExperiences of medical residentsCOVID-19 pandemicHealth care providersHealthcare delivery challengesLived experienceSemi-structured interviewsFear of infectionCare providersLimit situationPsychiatric careExistential defensivenessContent themesCOVID-19Social isolationEmotional overloadHealthcarePhenomenological analysisInductive analysisPublic healthPatient deathProfessional approachResidentsOvercome adversityAge of onset of obsessive-compulsive disorder differentially affects white matter microstructure
Vriend C, de Joode N, Pouwels P, Liu F, Otaduy M, Pastorello B, Robertson F, Ipser J, Lee S, Hezel D, van Meter P, Batistuzzo M, Hoexter M, Sheshachala K, Narayanaswamy J, Venkatasubramanian G, Lochner C, Miguel E, Reddy Y, Shavitt R, Stein D, Wall M, Simpson H, van den Heuvel O. Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure. Molecular Psychiatry 2024, 29: 1033-1045. PMID: 38228890, PMCID: PMC11176057, DOI: 10.1038/s41380-023-02390-8.Peer-Reviewed Original ResearchObsessive-compulsive disorderPathophysiology of obsessive-compulsive disorderObsessive-compulsive disorder groupAge of OCD onsetOCD onsetHealthy controlsMedication-free adultsWhite matter microstructural alterationsVisual attention processesWhite matter microstructureStructural brain networksStructural connectome analysisWhite matter tractsBayesian multilevel analysisDirection of effectAttentional processesOCD individualsBrain signaturesBrain networksDiffusion MRI studiesPost hoc analysisSagittal stratumConnectome analysisMultilevel analysisStructural connectomeSocial skills in patients with obsessive-compulsive disorder before and after treatment.
da Silva F, Batistuzzo M, Diniz J, D'Alcante C, Timpano K, Shavitt R, Miguel E, Hoexter M. Social skills in patients with obsessive-compulsive disorder before and after treatment. Brazilian Journal Of Psychiatry 2024 PMID: 38875529, DOI: 10.47626/1516-4446-2024-3577.Peer-Reviewed Original ResearchObsessive-compulsive disorderObsessive-compulsive disorder symptomatologySocial skillsIllness durationControl participantsSeverity of obsessive-compulsive disorderObsessive-compulsive disorder severityObsessive-compulsive disorder symptomsSS total scoreScores compared to controlsOCD symptomatologyGroup differencesIllness onsetPredictors of SSTotal scoreCourse of treatmentSymptomatologyTreatment investigationsSS performanceTreatment effectsIllnessDisordersTreatment-naive patientsSkillsFollow-up periodThe S20 Brazilian Mental Health Report for Building a Just World and a Sustainable Planet: Part II.
Mari J, Kapczinski F, Brunoni A, Gadelha A, Baldez D, Miguel E, Scorza F, Caye A, Quagliato L, De Boni R, Salum G, Nardi A. The S20 Brazilian Mental Health Report for Building a Just World and a Sustainable Planet: Part II. Brazilian Journal Of Psychiatry 2024 PMID: 38875470, DOI: 10.47626/1516-4446-2024-3707.Peer-Reviewed Original ResearchMental health reportsHealth reportsHuman rightsMental healthMental disordersMental health careMental health policyMental health systemMental health challengesHealth Working GroupMental healthcareHealth policyHealth systemMental illnessHealth careDigital healthPhysical needsHealth challengesGeneral HospitalPsychiatric patientsInterventional psychiatryRightsTreatment settingsHealthPost-pandemic worldChapter 21 Gamma Knife for psychiatric indications
Lopes A, de Arruda I, Batistuzzo M, Gorgulho A, de Salles A, Miguel E. Chapter 21 Gamma Knife for psychiatric indications. 2024, 495-517. DOI: 10.1016/b978-0-443-18496-3.00021-5.Peer-Reviewed Original ResearchAnorexia nervosaObsessive-compulsive disorder patientsTreatment of psychiatric disordersAnterior limb of internal capsuleObsessive-compulsive disorderVentral anterior limbGamma KnifeGK radiosurgeryMajor depressionDisorder patientsPsychiatric disordersPsychiatric indicationsNervosaDepressionInternal capsuleSurgical modalitiesAdverse eventsDisordersAnorexiaRadiosurgeryWeight gainManiaPsychiatryBrain cystsComplicationsChildhood Anxiety Symptoms as a Predictor of Psychotic Experiences in Adolescence in a High-Risk Cohort for Psychiatric Disorders
Machado V, Fonseca L, Barbosa M, Bressan R, Pan P, Rohde L, Miguel E, Salum G, Ziebold C, Gadelha A. Childhood Anxiety Symptoms as a Predictor of Psychotic Experiences in Adolescence in a High-Risk Cohort for Psychiatric Disorders. Schizophrenia Bulletin Open 2024, 5: sgae003. PMID: 39144118, PMCID: PMC11207689, DOI: 10.1093/schizbullopen/sgae003.Peer-Reviewed Original ResearchBrazilian High-Risk CohortCross-lagged panel modelChildhood anxiety symptomsPsychotic experiencesAnxiety symptomsSubclinical psychotic symptomsContinuum of psychosisStandardized self-report questionnairesTime-lagged associationsCross-lagged effectsIncreased levels of anxietySelf-report questionnairesLevels of anxietyPsychosis pronenessPsychotic symptomsPsychiatric disordersSymptom domainsMental illnessAnxietyHigh-risk cohortAnxiety scoresPsychosisAdolescentsPE scoresPanel model
2023
Clinical characteristics of probands with obsessive-compulsive disorder from simplex and multiplex families
Lima M, Saraiva L, Ramos V, Oliveira M, Costa D, Disorders B, Fernandez T, Crowley J, Storch E, Shavitt R, Miguel E, Cappi C. Clinical characteristics of probands with obsessive-compulsive disorder from simplex and multiplex families. Psychiatry Research 2023, 331: 115627. PMID: 38113811, PMCID: PMC11129832, DOI: 10.1016/j.psychres.2023.115627.Peer-Reviewed Original ResearchComparing mental health semi-structured diagnostic interviews and symptom checklists to predict poor life outcomes: an 8-year cohort study from childhood to young adulthood in Brazil
Hoffmann M, Pine D, Georgiades K, Szatmari P, Miguel E, Pan P, Gadelha A, Rohde L, Merikangas K, Milham M, Satterthwaite T, Salum G. Comparing mental health semi-structured diagnostic interviews and symptom checklists to predict poor life outcomes: an 8-year cohort study from childhood to young adulthood in Brazil. The Lancet Global Health 2023, 12: e79-e89. PMID: 37980914, PMCID: PMC10716620, DOI: 10.1016/s2214-109x(23)00462-x.Peer-Reviewed Original ResearchLatin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol
Crowley J, Cappi C, Ochoa‐Panaifo M, Frederick R, Kook M, Wiese A, Rancourt D, Atkinson E, Giusti‐Rodriguez P, Anderberg J, genomics L, Group B, Abramowitz J, Adorno V, Aguirre C, Alves G, Alves G, Ancalade N, Espinosa A, Arnold P, Ayton D, Barbosa I, Castano L, Barrera C, Berardo M, Berrones D, Best J, Bigdeli T, Burton C, Buxbaum J, Callahan J, Carneiro M, Cepeda S, Chazelle E, Chire J, Munoz M, Quiroz P, Cobite J, Comer J, Costa D, Crosbie J, Cruz V, Dager G, Daza L, de la Rosa‐Gómez A, del Río D, Delage F, Dreher C, Fay L, Fazio T, Ferrão Y, Ferreira G, Figueroa E, Fontenelle L, Forero D, Fragoso D, Gadad B, Garrison S, González A, Gonzalez L, González M, Gonzalez‐Barrios P, Goodman W, Grice D, Guintivano J, Guttfreund D, Guzick A, Halvorsen M, Hovey J, Huang H, Irreño‐Sotomonte J, Janssen‐Aguilar R, Jensen M, Reynolds A, Lujambio J, Khalfe N, Knutsen M, Lack C, Lanzagorta N, Lima M, Longhurst M, Martinez D, Luna E, Marques A, Martinez M, de Los Angeles Matos M, Maye C, McGuire J, Menezes G, Minaya C, Miño T, Mithani S, de C, Morales‐Rivero A, Moreira‐de‐Oliveira M, Morris O, Muñoz S, Naqqash Z, Bracho A, Bracho B, Rojas M, Castaman L, Balmaceda T, Ortega I, Patel D, Patrick A, Paz y Mino M, Orellana J, Stumpf B, Peregrina T, Duarte T, Piacsek K, Placencia M, Prieto M, Quarantini L, Quarantini‐Alvim Y, Ramos R, Ramos I, Ramos V, Ramsey K, Ray E, Richter M, Riemann B, Rivas J, Rosario M, Ruggero C, Ruiz‐Chow A, Ruiz‐Velasco A, Sagarnaga M, Sampaio A, Saraiva L, Schachar R, Schneider S, Schweissing E, Seligman L, Shavitt R, Soileau K, Stewart S, Storch S, Strouphauer E, Cuevas V, Timpano K, la Garza B, Vallejo‐Silva A, Vargas‐Medrano J, Vásquez M, Martinez G, Weinzimmer S, Yanez M, Zai G, Zapata‐Restrepo L, Zappa L, Zepeda‐Burgos R, Zoghbi A, Miguel E, Rodriguez C, Mallen M, Moya P, Borda T, Moyano M, Mattheisen M, Pereira S, Lázaro‐Muñoz G, Martinez‐Gonzalez K, Pato M, Nicolini H, Storch E. Latin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2023, 195: e32962. PMID: 37946624, PMCID: PMC11076176, DOI: 10.1002/ajmg.b.32962.Peer-Reviewed Original ResearchBrain activation during fear extinction recall in unmedicated patients with obsessive-compulsive disorder
Diniz J, Bazán P, Pereira C, Saraiva E, Ramos P, de Oliveira A, Reimer A, Hoexter M, Miguel E, Shavitt R, Batistuzzo M. Brain activation during fear extinction recall in unmedicated patients with obsessive-compulsive disorder. Psychiatry Research Neuroimaging 2023, 336: 111733. PMID: 37913655, DOI: 10.1016/j.pscychresns.2023.111733.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderExtinction recallNeutral stimuliFear conditioningFear extinction recallBlood oxygenation level-dependent (BOLD) responseFear conditioning experimentSkin conductance reactivitySpecific brain activation patternsBrain activation patternsSkin conductance responsesLevel-dependent responsesEntire sampleDACC activationUnmedicated adult patientsFear responsesBrain activationAversive stimuliLingual gyrusUnmedicated samplesActivation patternsHealthy participantsRecallOpercular cortexInsular cortexW27. POLYGENIC RISK SCORE AND HOUSEHOLD DEPRIVATION ARE RELATED TO INTERNALIZING SYMPTOMS IN YOUTH
Belangero S, De Oliveira A, Carvalho C, Ota V, Bugiga A, Pan P, Mauer J, Mari J, Santoro M, Miguel E, Hoffmann M, Salum G. W27. POLYGENIC RISK SCORE AND HOUSEHOLD DEPRIVATION ARE RELATED TO INTERNALIZING SYMPTOMS IN YOUTH. European Neuropsychopharmacology 2023, 75: s118-s119. DOI: 10.1016/j.euroneuro.2023.08.217.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsLinear mixed modelsMental disordersHigh Risk Cohort StudyInternalizing symptomsWell-Being AssessmentPotential biological markersParent reportGenome-wide association studiesSelf-report measuresTraumatic eventsCohort studyHigh prevalenceRisk scoreGene-environment interactionsPsychiatric disordersInternalizing psychopathologySignificant associationSymptomsBiological markersUnderlying causeHousehold deprivationScore studyInternalizing problemsEarly life