2023
Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents
Honorato-Mauer J, Xavier G, Ota V, Chehimi S, Mafra F, Cuóco C, Ito L, Ormond R, Asprino P, Oliveira A, Bugiga A, Torrecilhas A, Bressan R, Manfro G, Miguel E, Rohde L, Pan P, Salum G, Pellegrino R, Belangero S, Santoro M. Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents. Translational Psychiatry 2023, 13: 47. PMID: 36746925, PMCID: PMC9902559, DOI: 10.1038/s41398-023-02326-4.Peer-Reviewed Original ResearchConceptsMental health disordersCross-sectional analysisMajor depressive disorderAttention-deficit/hyperactivity disorderHealth disordersAnxiety disordersExtracellular vesiclesLarge ongoing cohort studiesMiR-432-5pPeripheral extracellular vesiclesTime pointsOngoing cohort studyMiR-328-3pSerum extracellular vesiclesLongitudinal analysisWave 2Deficit/hyperactivity disorderAdolescent participantsTotal extracellular vesiclesAttention-deficit/hyperactivityMiRNA expressionCohort studyDepressive disorderMajor depressionMiR-584-5p
2021
The impact of child psychiatric conditions on future educational outcomes among a community cohort in Brazil
Hoffmann M, McDaid D, Salum G, Silva-Ribeiro W, Ziebold C, King D, Gadelha A, Miguel E, de Jesus Mari J, Rohde L, Pan P, Bressan R, Mojtabai R, Evans-Lacko S. The impact of child psychiatric conditions on future educational outcomes among a community cohort in Brazil. Epidemiology And Psychiatric Sciences 2021, 30: e69. PMID: 36178130, PMCID: PMC8581950, DOI: 10.1017/s2045796021000561.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxiety DisordersBrazilChildDepressive Disorder, MajorEducational StatusFemaleHumansMalePhobic DisordersConceptsBullying perpetrationAdverse educational outcomesPsychiatric conditionsEducational outcomesWell-Being Behavior AssessmentImpact of fearHigh family riskMental health problemsFamily riskLiteracy performanceGrade repetitionChild psychiatric conditionsFuture educational outcomesCommunity cohortPopulation attributable risk percentageSchool dropoutPerpetrationNegative long-term effectsSample attritionAttributable risk percentageLarge Brazilian cohortBehavior assessmentNegative impactRobust negative impactBrazilian children
2017
Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample
Pan P, Sato J, Salum G, Rohde L, Gadelha A, Zugman A, Mari J, Jackowski A, Picon F, Miguel E, Pine D, Leibenluft E, Bressan R, Stringaris A. Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample. American Journal Of Psychiatry 2017, 174: 1112-1119. PMID: 28946760, PMCID: PMC10752293, DOI: 10.1176/appi.ajp.2017.17040430.Peer-Reviewed Original ResearchConceptsResting-state functional MRIIntrinsic functional connectivityDepressive disorderFunctional connectivityFunctional MRIReward networkFuture depressive disorderAdolescent depressive disordersLeft ventral striatumOnset of depressionBrain reward networksAberrant reward processingAttention deficit hyperactivity disorderDeficit hyperactivity disorderLongitudinal communityChildren 6Ventral striatumAdolescent depressionLogistic regressionHyperactivity disorderSubstance useYouth depressionDisordersDepressionFuture riskGene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder
Spindola L, Pan P, Moretti P, Ota V, Santoro M, Cogo-Moreira H, Gadelha A, Salum G, Manfro G, Mari J, Brentani H, Grassi-Oliveira R, Brietzke E, Miguel E, Rohde L, Sato J, Bressan R, Belangero S. Gene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder. Journal Of Psychiatric Research 2017, 92: 24-30. PMID: 28384542, DOI: 10.1016/j.jpsychires.2017.03.015.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild AbuseCohort StudiesDepressive Disorder, MajorFemaleGene ExpressionGenetic TestingHumansHypothalamo-Hypophyseal SystemInterleukin-1betaMaleModels, BiologicalPeptide FragmentsPituitary-Adrenal SystemReceptors, GlucocorticoidReceptors, Tumor Necrosis Factor, Type IResidence CharacteristicsRNA, MessengerTumor Necrosis Factor-alphaConceptsMajor depressive disorderBlood of childrenDepressive disorderChildhood maltreatmentMDD diagnosisRole of glucocorticoidsWhole blood mRNA levelsCM historyGene expressionAdrenal axisIllness exposureHealthy controlsDepressive symptomsMDD groupLarger studyMRNA expressionMRNA levelsExpression levelsInflammationTNFChildrenDiagnosisBloodAdolescentsNR3C1
2011
Suicidality in obsessive-compulsive disorder: prevalence and relation to symptom dimensions and comorbid conditions.
Torres A, Ramos-Cerqueira A, Ferrão Y, Fontenelle L, do Rosário M, Miguel E. Suicidality in obsessive-compulsive disorder: prevalence and relation to symptom dimensions and comorbid conditions. The Journal Of Clinical Psychiatry 2011, 72: 17-26; quiz 119-20. PMID: 21272513, DOI: 10.4088/jcp.09m05651blu.Peer-Reviewed Original ResearchMeSH KeywordsAdultComorbidityCross-Sectional StudiesDepressive Disorder, MajorDisruptive, Impulse Control, and Conduct DisordersFemaleHumansLongitudinal StudiesMaleObsessive-Compulsive DisorderPersonality InventoryPrevalenceReligion and PsychologyRisk FactorsSexual BehaviorStress Disorders, Post-TraumaticSuicideSuicide, AttemptedSurveys and QuestionnairesConceptsPosttraumatic stress disorderMajor depressive disorderObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleCurrent suicidal thoughtsSubstance use disordersImpulse control disordersSuicidal thoughtsObsessive Compulsive ScaleDepressive disorderUse disordersDSM-IV Axis I DisordersSuicidal behaviorComorbid substance use disorderCompulsive ScaleOCD patientsLifetime major depressive disorderCross-sectional studyStructured Clinical InterviewAxis I DisordersLogistic regression analysisPrimary obsessive-compulsive disorderSymptom dimensionsLifetime suicidal thoughtsBrazilian Research Consortium
2010
Comorbid major depression in obsessive-compulsive disorder patients
Quarantini L, Torres A, Sampaio A, Fossaluza V, de Mathis M, do Rosário M, Fontenelle L, Ferrão Y, Cordioli A, Petribu K, Hounie A, Miguel E, Shavitt R, Koenen K. Comorbid major depression in obsessive-compulsive disorder patients. Comprehensive Psychiatry 2010, 52: 386-393. PMID: 21087765, DOI: 10.1016/j.comppsych.2010.09.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrazilComorbidityDepressive Disorder, MajorFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPrevalenceSeverity of Illness IndexConceptsMajor depressive disorderObsessive-compulsive disorderOCD patientsCurrent major depressive disorderComorbid major depressive disorderLifetime major depressive disorderComprehensive psychiatric evaluationComorbid major depressionSevere general psychopathologyHigher severity scoresObsessive-compulsive disorder patientsSymptom dimensionsOCD symptom dimensionsClinical characteristicsFrequent complicationSeverity scoreDepressive disorderMajor depressionPrevalence ratesPsychiatric evaluationDisorder patientsPatientsGeneral psychopathologyDisordersOCD symptoms
2008
The Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders: recruitment, assessment instruments, methods for the development of multicenter collaborative studies and preliminary results
Miguel E, Ferrão Y, do Rosário M, de Mathis M, Torres A, Fontenelle L, Hounie A, Shavitt R, Cordioli A, Gonzalez C, Petribú K, Diniz J, Malavazzi D, Torresan R, Raffin A, Meyer E, Braga D, Borcato S, Valério C, Gropo L, da Silva Prado H, Perin E, Santos S, Copque H, Borges M, Lopes A, da Silva E. The Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders: recruitment, assessment instruments, methods for the development of multicenter collaborative studies and preliminary results. Brazilian Journal Of Psychiatry 2008, 30: 185-196. PMID: 18833417, DOI: 10.1590/s1516-44462008000300003.Peer-Reviewed Original Research