2018
Layer-specific reduced neuronal density in the orbitofrontal cortex of older adults with obsessive–compulsive disorder
de Oliveira K, Grinberg L, Hoexter M, Brentani H, Suemoto C, Nery F, Lima L, Alho A, Farfel J, Ferretti-Rebustini R, Leite R, Moretto A, da Silva A, Lafer B, Miguel E, Nitrini R, Jacob-Filho W, Heinsen H, Pasqualucci C. Layer-specific reduced neuronal density in the orbitofrontal cortex of older adults with obsessive–compulsive disorder. Brain Structure And Function 2018, 224: 191-203. PMID: 30298291, DOI: 10.1007/s00429-018-1752-8.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMedial orbitofrontalOrbitofrontal cortexNeuronal densityOCD casesLower neuron densityCortical-subcortical circuitryOFC abnormalitiesEfferent targetsNeuron densityClinical evaluationAnterolateral areaControl groupCognitive impairmentAutopsy serviceOrbitofrontal regionsAnteromedialOlder adultsControl casesOFC areasCortexConsistent evidenceDisordersCellular levelTotal
2014
Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study
Sato J, Salum G, Gadelha A, Vieira G, Zugman A, Picon F, Pan P, Hoexter M, Anés M, Moura L, Del’Aquilla M, Crossley N, Amaro E, Mcguire P, Lacerda A, Rohde L, Miguel E, Jackowski A, Bressan R. Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study. NeuroImage 2014, 104: 44-51. PMID: 25290886, DOI: 10.1016/j.neuroimage.2014.09.063.Peer-Reviewed Original ResearchConceptsAngular gyrusDevelopmental trajectoriesFunctional magnetic resonance imaging (fMRI) dataBrain developmental trajectoriesBrazilian community sampleBrain maturation processesFunctional connectivity studiesNetwork connectivity changesStructural imaging findingsInhibitory controlSensitive development periodCommunity sampleEmotional changesAbstract thoughtMagnetic resonance imaging dataComplex reasoningFMRI dataCerebellar regionsDevelopmental changesBrain regionsCortical regionsConnectivity changesConnectivity studiesSubcortical regionsAdolescenceAge effects on the default mode and control networks in typically developing children
Sato J, Salum G, Gadelha A, Picon F, Pan P, Vieira G, Zugman A, Hoexter M, Anés M, Moura L, Del'Aquilla M, Amaro E, McGuire P, Crossley N, Lacerda A, Rohde L, Miguel E, Bressan R, Jackowski A. Age effects on the default mode and control networks in typically developing children. Journal Of Psychiatric Research 2014, 58: 89-95. PMID: 25085608, DOI: 10.1016/j.jpsychires.2014.07.004.Peer-Reviewed Original ResearchConceptsDefault mode networkMode networkYears of ageCross-sectional community sampleRight anterior insulaDefault modePosterior temporal cortexDorsal anteriorAge effectsNeurodevelopment studiesHealthy subjectsTemporal cortexPosterior cingulateState fMRI dataAnterior insulaBrain developmentSame acquisition parametersLeft posterior temporal cortexNeuronal modulesState fMRILate childhoodDevelopmental formationBrain networksCommunity sampleField of neuroimaging
2010
Effects of childhood development on late-life mental disorders
Salum G, Polanczyk G, Miguel E, Rohde L. Effects of childhood development on late-life mental disorders. Current Opinion In Psychiatry 2010, 23: 498-503. PMID: 20733493, DOI: 10.1097/yco.0b013e32833ead33.Peer-Reviewed Original ResearchConceptsLate-life mental disordersMental disordersCentral nervous systemEnvironmental risk factorsChildhood developmentMental health trajectoriesPreventive intervention strategiesRisk factorsAtypical neurodevelopmentNervous systemPreventive interventionsHomotypic continuityHealth trajectoriesIntervention strategiesDisordersPsychiatric phenotypesCurrent findingsRecent findingsChildhoodAdulthoodUrgent needFindings documentNeurodevelopmentFindings