2019
The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects
Blanco‐Vieira T, Santos M, Ferrão YA, Torres AR, Miguel EC, Bloch MH, Leckman JF, do Rosario MC. The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects. Depression And Anxiety 2019, 36: 533-542. PMID: 30990937, DOI: 10.1002/da.22898.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderAdult OCD patientsObsessive-compulsive disorderDeficit hyperactivity disorderOCD patientsClinical characteristicsExact testFeatures of ADHDHyperactivity disorderSubgroup of patientsAdult obsessive-compulsive disorderComorbid attention deficit hyperactivity disorderSpecific clinical featuresCross-sectional studyObsessive-compulsive disorder (OCD) subjectsLogistic regression analysisFisher's exact testBrazilian Research ConsortiumMann-Whitney testAdult patientsRheumatic feverDevelopment of interventionsClinical featuresObsessive-compulsive spectrum disordersLifetime prevalenceInitial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis
Lisboa B, Oliveira K, Tahira A, Barbosa A, Feltrin A, Gouveia G, Lima L, Feio dos Santos A, Martins D, Puga R, Moretto A, De Bragança Pereira C, Lafer B, Leite R, Ferretti-Rebustini R, Farfel J, Grinberg L, Jacob-Filho W, Miguel E, Hoexter M, Brentani H. Initial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis. Scientific Reports 2019, 9: 3086. PMID: 30816141, PMCID: PMC6395771, DOI: 10.1038/s41598-019-38965-1.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSynaptic transmissionPathophysiology of OCDDifferent striatal subregionsPostmortem brain tissueChemical synaptic transmissionStriatal areasCortico-striatoNeurotransmitter levelsStriatum regionThalamic circuitryStriatal subregionsSubregion specificityPsychiatric disordersPresynaptic processesSynaptic plasticityBrain samplesOCD pathophysiologyBrain tissueCSTC modelControl casesPathophysiologyRare variantsDisordersCellular responses
2018
Layer-specific reduced neuronal density in the orbitofrontal cortex of older adults with obsessive–compulsive disorder
de Oliveira K, Grinberg L, Hoexter M, Brentani H, Suemoto C, Nery F, Lima L, Alho A, Farfel J, Ferretti-Rebustini R, Leite R, Moretto A, da Silva A, Lafer B, Miguel E, Nitrini R, Jacob-Filho W, Heinsen H, Pasqualucci C. Layer-specific reduced neuronal density in the orbitofrontal cortex of older adults with obsessive–compulsive disorder. Brain Structure And Function 2018, 224: 191-203. PMID: 30298291, DOI: 10.1007/s00429-018-1752-8.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMedial orbitofrontalOrbitofrontal cortexNeuronal densityOCD casesLower neuron densityCortical-subcortical circuitryOFC abnormalitiesEfferent targetsNeuron densityClinical evaluationAnterolateral areaControl groupCognitive impairmentAutopsy serviceOrbitofrontal regionsAnteromedialOlder adultsControl casesOFC areasCortexConsistent evidenceDisordersCellular levelTotal
2015
Comorbidity variation in patients with obsessive–compulsive disorder according to symptom dimensions: Results from a large multicentre clinical sample
Torres A, Fontenelle L, Shavitt R, Ferrão Y, do Rosário M, Storch E, Miguel E. Comorbidity variation in patients with obsessive–compulsive disorder according to symptom dimensions: Results from a large multicentre clinical sample. Journal Of Affective Disorders 2015, 190: 508-516. PMID: 26561941, DOI: 10.1016/j.jad.2015.10.051.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderObsessive-compulsive disorderAnxiety disordersTic disordersDimensional Yale-Brown Obsessive Compulsive ScaleSeparation anxiety disorderComorbid disordersSymptom dimensionsDifferent underlying pathogenic mechanismsTertiary mental health servicesDSM-IV Axis I DisordersSpecific phobiaMulticenter clinical studyPanic disorder/agoraphobiaAxis I DisordersStructured Clinical InterviewYale-Brown Obsessive Compulsive ScaleMental health servicesUnderlying pathogenic mechanismsImpulse control disordersBrazilian Research ConsortiumSocial phobiaBody dysmorphic disorderObsessive Compulsive ScaleCommon comorbiditiesDefining clinical severity in adults with obsessive–compulsive disorder
Storch E, De Nadai A, do Rosário M, Shavitt R, Torres A, Ferrão Y, Miguel E, Lewin A, Fontenelle L. Defining clinical severity in adults with obsessive–compulsive disorder. Comprehensive Psychiatry 2015, 63: 30-35. PMID: 26555489, PMCID: PMC4643407, DOI: 10.1016/j.comppsych.2015.08.007.Peer-Reviewed Original Research
2014
Phenomenology of OCD: Lessons from a large multicenter study and implications for ICD-11
Shavitt R, de Mathis M, Oki F, Ferrao Y, Fontenelle L, Torres A, Diniz J, Costa D, do Rosário M, Hoexter M, Miguel E, Simpson H. Phenomenology of OCD: Lessons from a large multicenter study and implications for ICD-11. Journal Of Psychiatric Research 2014, 57: 141-148. PMID: 25012187, PMCID: PMC7326117, DOI: 10.1016/j.jpsychires.2014.06.010.Peer-Reviewed Original ResearchMusical obsessions: A comprehensive review of neglected clinical phenomena
Taylor S, McKay D, Miguel E, De Mathis M, Andrade C, Ahuja N, Sookman D, Kwon J, Huh M, Riemann B, Cottraux J, O’Connor K, Hale L, Abramowitz J, Fontenelle L, Storch E. Musical obsessions: A comprehensive review of neglected clinical phenomena. Journal Of Anxiety Disorders 2014, 28: 580-589. PMID: 24997394, DOI: 10.1016/j.janxdis.2014.06.003.Peer-Reviewed Original ResearchAdolescentAdultAgedAged, 80 and overAntipsychotic AgentsAvoidance LearningChildCognitive Behavioral TherapyDiagnosis, DifferentialFearFemaleHallucinationsHumansImaginationMaleMiddle AgedModels, PsychologicalMusicObsessive BehaviorObsessive-Compulsive DisorderSelective Serotonin Reuptake InhibitorsYoung Adult
2012
Clinical correlates of social adjustment in patients with obsessive-compulsive disorder
Rosa A, Diniz J, Fossaluza V, Torres A, Fontenelle L, De Mathis A, da Conceição Rosário M, Miguel E, Shavitt R. Clinical correlates of social adjustment in patients with obsessive-compulsive disorder. Journal Of Psychiatric Research 2012, 46: 1286-1292. PMID: 22800713, DOI: 10.1016/j.jpsychires.2012.05.019.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPoor social adjustmentSocial adjustmentSocial functioningOverall social functioningYale-Brown ObsessiveOCD severityReligious obsessionsCompulsive ScaleCurrent post-traumatic stress disorderSpecific OCD symptomsPost-traumatic stress disorderPrimary DSM-IV diagnosisOCD symptom onsetPoor social functioningSocial adjustment measuresObsessive-compulsive spectrum disordersGreater OCD severitySocial Adjustment ScaleBrazilian Research ConsortiumPoorer overall social functioningDimensional Yale-Brown ObsessivePsychiatric comorbidityCurrent psychiatric comorbidityCurrent major depressive disorder
2011
Brazilian psychiatric brain bank: a new contribution tool to network studies
de Oliveira K, Nery F, Ferreti R, Lima M, Cappi C, Machado-Lima A, Polichiso L, Carreira L, Ávila C, Alho A, Brentani H, Miguel E, Heinsen H, Jacob-Filho W, Pasqualucci C, Lafer B, Grinberg L. Brazilian psychiatric brain bank: a new contribution tool to network studies. Cell And Tissue Banking 2011, 13: 315-326. PMID: 21562728, DOI: 10.1007/s10561-011-9258-0.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderBipolar disorderBrain BankBrazilian Aging Brain Study GroupMajor depressive disorderSubstance use disordersMood disorder NOSDepressive disorderStudy groupPsychiatric assessmentDisorder NOSUse disordersAverage ageAutopsy serviceNeuropsychiatric diseasesObsessive-compulsive spectrum symptomsOCD patientsOptimal fixationDisordersCompulsive disorderSpectrum symptomsBrainPsychiatric researchMolecular studiesUrgent need
2001
Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette’s syndrome, Sydenham’s chorea, and autoimmune disorders
Morshed S, Parveen S, Leckman J, Mercadante M, Kiss M, Miguel E, Arman A, Yazgan Y, Fujii T, Paul S, Peterson B, Zhang H, King R, Scahill L, Lombroso P. Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette’s syndrome, Sydenham’s chorea, and autoimmune disorders. Biological Psychiatry 2001, 50: 566-577. PMID: 11690591, DOI: 10.1016/s0006-3223(01)01096-4.Peer-Reviewed Original ResearchConceptsTotal antinuclear antibodiesAntinuclear antibodiesAutoimmune disordersTourette syndromeAnticytoskeletal antibodiesAntineural antibodiesStreptococcal infectionT patientsTS patientsBeta-hemolytic streptococcal infectionPrior streptococcal infectionHemolytic streptococcal infectionAntistreptolysin O titerIndirect immunofluorescent assayLevels of immunoreactivityWestern blot techniqueMean rankClinical characteristicsSydenham's choreaO titerPatient groupSC patientsIgG antibodiesIgG classNormal controls