2022
Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways
Axelrud L, Hoffmann M, Vosberg D, Santoro M, Pan P, Gadelha A, Belangero S, Miguel E, Shin J, Thapar A, Smoller J, Pausova Z, Rohde L, Keller M, Paus T, Salum G. Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways. Journal Of Child Psychology And Psychiatry 2022, 64: 408-416. PMID: 36162806, DOI: 10.1111/jcpp.13708.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderPolygenic scoresOffspring cognitionIntergenerational transmissionMultiple mediation modelEducational attainmentBehavioral traitsCognitive measuresExecutive functionGeneral intelligenceHyperactivity disorderMediation modelMultiple mediationCognitive AssessmentCognitionPsychopathologyGenetic influencesParental educationPsychotic symptomsDirect associationParental geneticsAttainmentDiscovery sampleGenetic riskFathersThreat and deprivation are associated with distinct aspects of cognition, emotional processing, and psychopathology in children and adolescents
Schäfer J, McLaughlin K, Manfro G, Pan P, Rohde L, Miguel E, Simioni A, Hoffmann M, Salum G. Threat and deprivation are associated with distinct aspects of cognition, emotional processing, and psychopathology in children and adolescents. Developmental Science 2022, 26: e13267. PMID: 35417607, PMCID: PMC10028496, DOI: 10.1111/desc.13267.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild DevelopmentCognitionCross-Sectional StudiesEmotionsExecutive FunctionHumansConceptsChild Behavior ChecklistExecutive functionEmotional processingChildhood adversityBrazilian High-Risk CohortForms of adversityPoor developmental outcomesAttention biasAngry facesCognitive tasksCognitive developmentDevelopmental correlatesBehavior ChecklistChild developmentDevelopmental outcomesLongitudinal associationsGeneral psychopathologyPsychopathologyAdversityLatent constructsDifferential associationsWorse performanceDistinct aspectsCognitionMeaningful influenceNeurocircuit models of obsessive-compulsive disorder: limitations and future directions for research
Shephard E, Batistuzzo M, Hoexter M, Stern E, Zuccolo P, Ogawa C, Silva R, Brunoni A, Costa D, Doretto V, Saraiva L, Cappi C, Shavitt R, Simpson H, van den Heuvel O, Miguel E. Neurocircuit models of obsessive-compulsive disorder: limitations and future directions for research. Brazilian Journal Of Psychiatry 2022, 44: 187-200. PMID: 35617698, PMCID: PMC9041967, DOI: 10.1590/1516-4446-2020-1709.Peer-Reviewed Original ResearchMeSH KeywordsCognitionCompulsive BehaviorHumansNeuroimagingObsessive BehaviorObsessive-Compulsive DisorderConceptsObsessive-compulsive disorderCourse of OCDCognitive mechanismsCommon psychiatric conditionsSpecific neurocircuitsCognitive functionNeurocognitive functionPsychiatric conditionsFuture researchComplexity of brainFuture directionsDisordersCurrent reviewNeuroscienceNeurocircuitsCompulsionResearchSymptomatologyObsessionExperiences of patientsExperienceImportant limitationsPresentationBetter understandingBrainDNA methylation mediates a randomized controlled trial home-visiting intervention during pregnancy and the Bayley infant’s cognitive scores at 12 months of age
Euclydes V, Gastaldi V, Feltrin A, Hoffman D, Gouveia G, Cogo H, Felipe-Silva A, Vieira R, Miguel E, Polanczyk G, Chiesa A, Fracolli L, Matijasevich A, Ferraro A, Argeu A, Maschietto M, Brentani H. DNA methylation mediates a randomized controlled trial home-visiting intervention during pregnancy and the Bayley infant’s cognitive scores at 12 months of age. Journal Of Developmental Origins Of Health And Disease 2022, 13: 556-565. PMID: 35256034, DOI: 10.1017/s2040174421000738.Peer-Reviewed Original ResearchPost-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study
Damiano R, Caruso M, Cincoto A, de Almeida Rocca C, de Pádua Serafim A, Bacchi P, Guedes B, Brunoni A, Pan P, Nitrini R, Beach S, Fricchione G, Busatto G, Miguel E, Forlenza O, Group H. Post-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study. General Hospital Psychiatry 2022, 75: 38-45. PMID: 35134702, PMCID: PMC8734055, DOI: 10.1016/j.genhosppsych.2022.01.002.Peer-Reviewed Original ResearchConceptsCognitive morbidityCognitive outcomesAnxiety disordersPost-traumatic stress disorderRelevant psychosocial variablesCognitive batteryMemory declineStructured psychiatric interviewStress disorderPsychosocial variablesStandardized measuresPsychosocial stressorsPsychometric testsCognitive impairmentPsychiatric interviewSevere formPreliminary findingsSARS-CoV-2 infectionCohort of survivorsLong-term outcomesAcute-phase diseaseBrazilian cohort studyCOVID-19DisordersDepressionInattention symptoms in early pregnancy predict parenting skills and infant maltreatment during the first year of life
de Oliveira J, Fatori D, Shephard E, Xavier M, Matijasevich A, Ferraro A, Rohde L, Chiesa A, Miguel E, Polanczyk G. Inattention symptoms in early pregnancy predict parenting skills and infant maltreatment during the first year of life. Brazilian Journal Of Psychiatry 2022, 44: 388-400. PMID: 35751597, PMCID: PMC9375657, DOI: 10.47626/1516-4446-2021-2045.Peer-Reviewed Original ResearchConceptsMaternal attention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorderHyperactivity/impulsivity symptomsInattention symptomsImpulsivity symptomsAdolescent mothersHyperactivity disorderMaternal inattentionInfant maltreatmentEarly intervention programsParenting skillsPoor home environmentInfant developmentIntervention programsInattentionChild maltreatmentMaternal competenceMaltreatmentSkillsHome visit programHome environmentFirst yearInfant's lifeMultilevel linear regression modelsEarly pregnancy
2020
Cognitive performance in children and adolescents at high-risk for obsessive-compulsive disorder
Bernardes E, Saraiva L, e Souza M, Hoexter M, Chacon P, Requena G, Miguel E, Shavitt R, Polanczyk G, Cappi C, Batistuzzo M. Cognitive performance in children and adolescents at high-risk for obsessive-compulsive disorder. BMC Psychiatry 2020, 20: 380. PMID: 32690046, PMCID: PMC7370498, DOI: 10.1186/s12888-020-02751-5.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderObsessive-compulsive symptomsNeurocognitive domainsPediatric obsessive-compulsive disorderNon-verbal memoryProcessing speed domainCognitive domain analysisComprehensive neuropsychological batteryNon-clinical sampleYale-Brown ObsessiveSubdomain analysisVisuospatial memoryCognitive domainsExecutive functionVisuoconstructive abilitiesVisuoconstructive tasksCognitive performanceNeuropsychological variablesNeuropsychological batteryStructured Clinical InterviewProcessing speedNeurocognitive assessmentSpeed domainOCS severityCompulsive ScaleEffects of semantic categorization strategy training on episodic memory in children and adolescents
Miotto E, Balardin J, da Graça M. Martin M, Polanczyk G, Savage C, Miguel E, Batistuzzo M. Effects of semantic categorization strategy training on episodic memory in children and adolescents. PLOS ONE 2020, 15: e0228866. PMID: 32069310, PMCID: PMC7028277, DOI: 10.1371/journal.pone.0228866.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingEpisodic memoryPrefrontal cortexCognitive trainingStrategy trainingMiddle frontal gyrus activationDefault mode network areasVerbal episodic memoryImproved memory performanceRight frontal poleLateral orbital gyrusCategorization trainingSuccessful memoryExecutive processesNeural correlatesMemory performanceWord listsAnterior cingulateFrontal poleMemoryHigher activationBrain regionsAdolescentsOrbital gyrusBehavioral effects
2018
Socioeconomic diversities and infant development at 6 to 9 months in a poverty area of São Paulo, Brazil
Tella P, da Rosa Piccolo L, Rangel M, Rohde L, Polanczyk G, Miguel E, Grisi S, Fleitlich-Bilyk B, Ferraro A. Socioeconomic diversities and infant development at 6 to 9 months in a poverty area of São Paulo, Brazil. Trends In Psychiatry And Psychotherapy 2018, 40: 232-240. PMID: 30156646, DOI: 10.1590/2237-6089-2017-0008.Peer-Reviewed Original ResearchConceptsCognitive developmentInfant developmentInfant languageInfants' performanceMaternal educationCognitive scoresMotor skillsSocioeconomic statusIntervention effortsBayley ScalesHigh languageSES effectsParticipant familiesEarly childhoodMotor ScaleLanguageSocioeconomic backgroundHigher maternal educationPositive associationChildhoodSocioeconomic diversityInfancySkillsFirst yearChildrenPolygenic Risk Score for Alzheimer’s Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life
Axelrud L, Santoro M, Pine D, Talarico F, Gadelha A, Manfro G, Pan P, Jackowski A, Picon F, Brietzke E, Grassi-Oliveira R, Bressan R, Miguel E, Rohde L, Hakonarson H, Pausova Z, Belangero S, Paus T, Salum G. Polygenic Risk Score for Alzheimer’s Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life. American Journal Of Psychiatry 2018, 175: 555-563. PMID: 29495896, PMCID: PMC6372950, DOI: 10.1176/appi.ajp.2017.17050529.Peer-Reviewed Original ResearchConceptsHippocampal volumeEarly-life cognitionCanadian sampleMemory taskCognitive abilitiesExecutive functionImmediate recallMemory performanceCognitive testsGenetic riskReplication sampleBrain algorithmPolygenic risk scoresStandardized testsLower hippocampal volumeDistinct tasksBrain structuresAlzheimer's diseaseCognitionIndependent samplesLate-life dementiaDevelopmental conditionsRecallPrevious evidenceTask
2000
CHARACTERIZATION OF TRICHOTILLOMANIA A Phenomenological Model with Clinical Relevance to Obsessive-Compulsive Spectrum Disorders
O'Sullivan R, Mansueto C, Lerner E, Miguel E. CHARACTERIZATION OF TRICHOTILLOMANIA A Phenomenological Model with Clinical Relevance to Obsessive-Compulsive Spectrum Disorders. Psychiatric Clinics Of North America 2000, 23: 587-604. PMID: 10986729, DOI: 10.1016/s0193-953x(05)70182-9.Peer-Reviewed Original Research
1996
Recall and recognition memory in obsessive-compulsive disorder
Savage C, Keuthen N, Jenike M, Brown H, Baer L, Kendrick A, Miguel E, Rauch S, Albert M. Recall and recognition memory in obsessive-compulsive disorder. Journal Of Neuropsychiatry 1996, 8: 99-103. PMID: 8845711, DOI: 10.1176/jnp.8.1.99.Peer-Reviewed Original Research