2023
Comparing mental health semi-structured diagnostic interviews and symptom checklists to predict poor life outcomes: an 8-year cohort study from childhood to young adulthood in Brazil
Hoffmann M, Pine D, Georgiades K, Szatmari P, Miguel E, Pan P, Gadelha A, Rohde L, Merikangas K, Milham M, Satterthwaite T, Salum G. Comparing mental health semi-structured diagnostic interviews and symptom checklists to predict poor life outcomes: an 8-year cohort study from childhood to young adulthood in Brazil. The Lancet Global Health 2023, 12: e79-e89. PMID: 37980914, PMCID: PMC10716620, DOI: 10.1016/s2214-109x(23)00462-x.Peer-Reviewed Original ResearchLongitudinal invariance of psychotic experiences in children and adolescents: What do the data tell us?
Barbosa M, Machado V, Ziebold C, Moriyama T, Bressan R, Pan P, Rohde L, Miguel E, Fonseca L, Van Os J, Gadelha A. Longitudinal invariance of psychotic experiences in children and adolescents: What do the data tell us? Schizophrenia Research 2023, 255: 33-40. PMID: 36958268, DOI: 10.1016/j.schres.2023.03.003.Peer-Reviewed Original ResearchConceptsPsychotic experiencesTime pointsHigh-risk cohortPrevious systematic reviewDifferent age groupsDifferent time pointsBaseline evaluationLifetime psychotic experiencesPositive symptomsSystematic reviewAge groupsPerceptual abnormalitiesLongitudinal studyBrazilian High-Risk CohortPsychosis pronenessGood model fit indicesThree-factor solutionChildrenPolygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample
Sato J, Biazoli C, Bueno A, Caye A, Pan P, Santoro M, Honorato‐Mauer J, Salum G, Hoexter M, Bressan R, Jackowski A, Miguel E, Belangero S, Rohde L. Polygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample. Genes Brain & Behavior 2023, 22: e12838. PMID: 36811275, PMCID: PMC10067387, DOI: 10.1111/gbb.12838.Peer-Reviewed Original ResearchConceptsCingulo-opercular networkDefault mode networkADHD-PRSAttentional networksFunctional segregationAttention-deficit/hyperactivity disorder (ADHD) symptomsAttention-deficit/hyperactivity disorderLarge-scale brain networksADHD polygenic risk scoresHyperactivity disorder symptomsSegregation of networksFunctional network segregationLongitudinal community-based cohortAttentional processesRs-fMRI dataExecutive functionHyperactivity disorderDisorder symptomsBrain networksCommunity-based sampleProbable ADHDADHDNetwork segregationPolygenic risk scoresDirection of associationDepression in mothers at childhood: Direct and indirect association with problematic gaming in late adolescence/young adulthood
Roza T, Rabelo-da-Ponte F, Spritzer D, Hoffmann M, Massuda R, Salum G, Miguel E, Rohde L, Pan P, Kessler F, Gadelha A, Passos I. Depression in mothers at childhood: Direct and indirect association with problematic gaming in late adolescence/young adulthood. Journal Of Psychiatric Research 2023, 159: 14-21. PMID: 36652752, DOI: 10.1016/j.jpsychires.2023.01.022.Peer-Reviewed Original ResearchConceptsAdolescence/young adulthoodMothers' depressionLate adolescence/young adulthoodRisk factorsSchool-based cohortYoung adulthoodMultiple confounding factorsLogistic regression modelsInverse probability weightsConfounding factorsExternalizing disordersInternalizing disordersDepressionPotential roleDisordersChildhoodMediatorsRegression modelsMothersSexAdulthoodInternalizing psychopathologySignificant mediatorMediation analysisAssociation
2022
Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive-Behavioral Therapy in Children With Obsessive-Compulsive Disorder
Bertolín S, Alonso P, Martínez-Zalacaín I, Menchón J, Jimenez-Murcia S, Baker J, Bargalló N, Batistuzzo M, Boedhoe P, Brennan B, Feusner J, Fitzgerald K, Fontaine M, Hansen B, Hirano Y, Hoexter M, Huyser C, Jahanshad N, Jaspers-Fayer F, Kuno M, Kvale G, Lazaro L, Machado-Sousa M, Marsh R, Morgado P, Nakagawa A, Norman L, Nurmi E, O’Neill J, Ortiz A, Perriello C, Piacentini J, Picó-Pérez M, Shavitt R, Shimizu E, Simpson H, Stewart S, Thomopoulos S, Thorsen A, Walitza S, Wolters L, Group E, Real E, Segalas C, Morer A, Brem S, Ferreira S, Moreira P, Hagen K, Hamatani S, Takahashi J, Yoshida T, de Mathis M, Miguel E, Pariente J, Tang J, Thompson P, van den Heuvel O, Stein D, Soriano-Mas C. Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive-Behavioral Therapy in Children With Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 62: 403-414. PMID: 36526161, PMCID: PMC10065927, DOI: 10.1016/j.jaac.2022.07.865.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyObsessive-compulsive disorderCBT responseCortical thicknessMagnetic Resonance Imaging PredictorsBaseline cortical thicknessPrefrontal cortex thicknessFirst-line treatmentRostral middle frontal gyrusPrefrontal cortical thicknessIdentification of predictorsHigher cortical thicknessMiddle frontal gyrusRight prefrontal cortexCortical surface areaMechanism of actionAdult patientsImaging predictorsPrefrontal cortex regionsClinical managementLarge seriesSubcortical volumesAdult populationFrontal polePrefrontal cortexDeviations from a typical development of the cerebellum in youth are associated with psychopathology, executive functions and educational outcomes
Borges M, Hoffmann M, Simioni A, Axelrud L, Teixeira D, Zugman A, Jackowski A, Pan P, Bressan R, Parker N, Germann J, Bado P, Satterthwaite T, Milham M, Chakravarty M, Rohde L, Miguel E, Paus T, Salum G. Deviations from a typical development of the cerebellum in youth are associated with psychopathology, executive functions and educational outcomes. Psychological Medicine 2022, 53: 5698-5708. PMID: 36226568, DOI: 10.1017/s0033291722002926.Peer-Reviewed Original ResearchConceptsExecutive functionTypical developmentInhibitory controlAcademic achievementCerebellar volumeHigher executive functionChild Behavior ChecklistTypical brain developmentSchool achievementBehavior ChecklistMental health conditionsStandardized measuresMediation analysisMental healthHigh Risk Cohort StudyEducational outcomesPsychopathologyBrain developmentMental conditionLongitudinal analysisYouthSpecific factorsAchievementCognitionAdolescenceAssociations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium
Ivanov I, Boedhoe PSW, Abe Y, Alonso P, Ameis SH, Arnold PD, Balachander S, Baker JT, Banaj N, Bargalló N, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Brem S, Brennan BP, Buitelaar J, Calvo R, Cheng Y, Cho KIK, Dallaspezia S, Denys D, Diniz JB, Ely BA, Feusner JD, Ferreira S, Fitzgerald KD, Fontaine M, Gruner P, Hanna GL, Hirano Y, Hoexter MQ, Huyser C, Ikari K, James A, Jaspers-Fayer F, Jiang H, Kathmann N, Kaufmann C, Kim M, Koch K, Kwon JS, Lázaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Morer A, Morgado P, Nakagawa A, Nakamae T, Nakao T, Narayanaswamy JC, Nurmi EL, Oh S, Perriello C, Piacentini JC, Picó-Pérez M, Piras F, Piras F, Reddy YCJ, Manrique DR, Sakai Y, Shimizu E, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Tolin DF, van Rooij D, Veltman DJ, van der Werf YD, van Wingen GA, Venkatasubramanian G, Walitza S, Wang Z, Watanabe A, Wolters LH, Xu X, Yun JY, Zarei M, Zhang F, Zhao Q, Jahanshad N, Thomopoulos SI, Thompson PM, Stein DJ, van den Heuvel OA, O'Neill J, Group T, Poletti S, Fridgeirsson E, Ikuta T, de Wit S, Vriend C, Kasprzak S, Kuno M, Takahashi J, Miguel E, Shavitt R, Hough M, Pariente J, Ortiz A, Bertolín S, Real E, Segalàs C, Moreira P, Sousa N, Narumoto J, Yamada K, Tang J, Fouche J, Kim T, Choi S, Ha M, Park S. Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium. Journal Of Affective Disorders 2022, 318: 204-216. PMID: 36041582, DOI: 10.1016/j.jad.2022.08.084.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderUnmedicated patientsOlder adultsAssociation of medicationVolumes of putamenSubcortical brain structuresReuptake inhibitorsVentricular hypertrophyHippocampal atrophyMedicated patientsPsychotropic medicationsTherapeutic responseHippocampal volumeStriatal volumeSubcortical nucleiPatientsPsychotic disordersAntipsychoticsSubcortical morphologyStructural MRINormal agingBrain structuresBenzodiazepinesOCD patientsENIGMA consortiumChildhood individual and family modifiable risk factors for criminal conviction: a 7-year cohort study from Brazil
Ziebold C, Evans-Lacko S, Andrade M, Hoffmann M, Fonseca L, Barbosa M, Pan P, Miguel E, Bressan R, Rohde L, Salum G, de Jesus Mari J, Gadelha A. Childhood individual and family modifiable risk factors for criminal conviction: a 7-year cohort study from Brazil. Scientific Reports 2022, 12: 13381. PMID: 35927553, PMCID: PMC9352677, DOI: 10.1038/s41598-022-13975-8.Peer-Reviewed Original ResearchConceptsCriminal convictionsImportance of povertyPublic problemsPopulation attributable risk fractionBrazilian youthGreat social impactYoung peopleModifiable risk factorsPovertySocial impactCrimeConvictionRisk factorsSubsequent criminal convictionsEradication interventionsChildren's exposureMiddle-income countriesFamily exposureYouthMultiple modifiable risk factorsOnly modifiable risk factorAttributable risk fractionSignificant risk factorsMajor public problemCohort studyWorld Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders – Version 3. Part II: OCD and PTSD
Bandelow B, Allgulander C, Baldwin D, da Conceição Costa D, Denys D, Dilbaz N, Domschke K, Hollander E, Kasper S, Möller H, Eriksson E, Fineberg N, Hättenschwiler J, Kaiya H, Karavaeva T, Katzman M, Kim Y, Inoue T, Lim L, Masdrakis V, Menchón J, Miguel E, Nardi A, Pallanti S, Perna G, Rujescu D, Starcevic V, Stein D, Tsai S, Van Ameringen M, Vasileva A, Wang Z, Zohar J. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders – Version 3. Part II: OCD and PTSD. The World Journal Of Biological Psychiatry 2022, 24: 118-134. PMID: 35900217, DOI: 10.1080/15622975.2022.2086296.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsRepetitive transcranial magnetic stimulationCognitive behavioral therapyFirst-line treatmentDeep brain stimulationSSRI treatmentBiological Psychiatry (WFSBP) GuidelinesSecond-line medicationsNon-pharmacological treatmentSerotonin reuptake inhibitorsNon-pharmacological interventionsTreatment-resistant casesTranscranial magnetic stimulationWorld FederationTreatment of anxietyPosttraumatic stress disorderTreatment of OCDReuptake inhibitorsMedication treatmentPharmacological treatmentSNRI venlafaxineInternet-CBTConsensus panelMagnetic stimulationBrain stimulationWorld Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders – Version 3. Part I: Anxiety disorders
Bandelow B, Allgulander C, Baldwin D, da Conceição Costa D, Denys D, Dilbaz N, Domschke K, Eriksson E, Fineberg N, Hättenschwiler J, Hollander E, Kaiya H, Karavaeva T, Kasper S, Katzman M, Kim Y, Inoue T, Lim L, Masdrakis V, Menchón J, Miguel E, Möller H, Nardi A, Pallanti S, Perna G, Rujescu D, Starcevic V, Stein D, Tsai S, Van Ameringen M, Vasileva A, Wang Z, Zohar J. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders – Version 3. Part I: Anxiety disorders. The World Journal Of Biological Psychiatry 2022, 24: 79-117. PMID: 35900161, DOI: 10.1080/15622975.2022.2086295.Peer-Reviewed Original ResearchConceptsSocial anxiety disorderCognitive behavioral therapyAnxiety disordersPanic disorder/agoraphobiaMixed anxiety disordersPosttraumatic stress disorderSerotonin-norepinephrine reuptake inhibitorsSelective serotonin reuptake inhibitorsTreatment of anxietyFirst-line psychotherapySelective mutismBehavioral therapySeparation anxietyStress disorderSpecific phobiaObsessive-CompulsiveReuptake inhibitorsAnxietyNon-pharmacological interventionsBiological Psychiatry (WFSBP) GuidelinesFirst-line medicationSerotonin reuptake inhibitorsAdolescentsAssessment of medicationsPsychotherapyThe influence of caregiver attitudes and socioeconomic group on formal and informal mental health service use among youth
Paula C, Ziebold C, Ribeiro W, Pan P, Mari J, Bressan R, Miguel E, Rohde L, Salum G, Evans-Lacko S. The influence of caregiver attitudes and socioeconomic group on formal and informal mental health service use among youth. European Psychiatry 2022, 65: e34. PMID: 35684952, PMCID: PMC9251818, DOI: 10.1192/j.eurpsy.2022.24.Peer-Reviewed Original ResearchConceptsMental health careCare utilizationTreatment accessService useMental health service useMental health care utilizationParental stigmaMental healthHigh-risk cohortHealth care utilizationHealth service useHealth careLow socioeconomic classMental health conditionsType of careLogistic regression modelsLow-resource settingsInformal careMental health supportFacilitators/barriersYouth mental healthFormal service useHigher oddsCaregiver characteristicsCaregiver attitudesThreat and deprivation are associated with distinct aspects of cognition, emotional processing, and psychopathology in children and adolescents
Schäfer J, McLaughlin K, Manfro G, Pan P, Rohde L, Miguel E, Simioni A, Hoffmann M, Salum G. Threat and deprivation are associated with distinct aspects of cognition, emotional processing, and psychopathology in children and adolescents. Developmental Science 2022, 26: e13267. PMID: 35417607, PMCID: PMC10028496, DOI: 10.1111/desc.13267.Peer-Reviewed Original ResearchConceptsChild Behavior ChecklistExecutive functionEmotional processingChildhood adversityBrazilian High-Risk CohortForms of adversityPoor developmental outcomesAttention biasAngry facesCognitive tasksCognitive developmentDevelopmental correlatesBehavior ChecklistChild developmentDevelopmental outcomesLongitudinal associationsGeneral psychopathologyPsychopathologyAdversityLatent constructsDifferential associationsWorse performanceDistinct aspectsCognitionMeaningful influenceInattention symptoms in early pregnancy predict parenting skills and infant maltreatment during the first year of life
de Oliveira J, Fatori D, Shephard E, Xavier M, Matijasevich A, Ferraro A, Rohde L, Chiesa A, Miguel E, Polanczyk G. Inattention symptoms in early pregnancy predict parenting skills and infant maltreatment during the first year of life. Brazilian Journal Of Psychiatry 2022, 44: 388-400. PMID: 35751597, PMCID: PMC9375657, DOI: 10.47626/1516-4446-2021-2045.Peer-Reviewed Original ResearchConceptsMaternal attention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorderHyperactivity/impulsivity symptomsInattention symptomsImpulsivity symptomsAdolescent mothersHyperactivity disorderMaternal inattentionInfant maltreatmentEarly intervention programsParenting skillsPoor home environmentInfant developmentIntervention programsInattentionChild maltreatmentMaternal competenceMaltreatmentSkillsHome visit programHome environmentFirst yearInfant's lifeMultilevel linear regression modelsEarly pregnancy
2021
The impact of child psychiatric conditions on future educational outcomes among a community cohort in Brazil
Hoffmann M, McDaid D, Salum G, Silva-Ribeiro W, Ziebold C, King D, Gadelha A, Miguel E, de Jesus Mari J, Rohde L, Pan P, Bressan R, Mojtabai R, Evans-Lacko S. The impact of child psychiatric conditions on future educational outcomes among a community cohort in Brazil. Epidemiology And Psychiatric Sciences 2021, 30: e69. PMID: 36178130, PMCID: PMC8581950, DOI: 10.1017/s2045796021000561.Peer-Reviewed Original ResearchConceptsBullying perpetrationAdverse educational outcomesPsychiatric conditionsEducational outcomesWell-Being Behavior AssessmentImpact of fearHigh family riskMental health problemsFamily riskLiteracy performanceGrade repetitionChild psychiatric conditionsFuture educational outcomesCommunity cohortPopulation attributable risk percentageSchool dropoutPerpetrationNegative long-term effectsSample attritionAttributable risk percentageLarge Brazilian cohortBehavior assessmentNegative impactRobust negative impactBrazilian childrenLong‐term stability of the cortical volumetric profile and the functional human connectome throughout childhood and adolescence
Sato J, Biazoli C, Zugman A, Pan P, Bueno A, Moura L, Gadelha A, Picon F, Amaro E, Salum G, Miguel E, Rohde L, Bressan R, Jackowski A. Long‐term stability of the cortical volumetric profile and the functional human connectome throughout childhood and adolescence. European Journal Of Neuroscience 2021, 54: 6187-6201. PMID: 34460993, DOI: 10.1111/ejn.15435.Peer-Reviewed Original ResearchConceptsFunctional connectomeVolumetric profileLarge-scale functional networksDorsal attention networkBrain functional connectomeIdentification accuracyStructural brain featuresFunctional connectivity profilesProtracted developmentBrain featuresConnectivity profilesFunctional networksHuman connectomeConnectomeNeurodevelopmental processesLongitudinal cohortAdolescenceAdolescentsWhole brainSubject variabilityChildrenChildhoodLarge-scale networksScan intervalFunctional profilesMental Health Impact in Latin American Pediatric Rheumatologists During the COVID-19 Pandemic
Kozu K, Casella C, Strabelli C, Aikawa N, Campos L, Elias A, Miguel E, Polanczyk G, Silva C. Mental Health Impact in Latin American Pediatric Rheumatologists During the COVID-19 Pandemic. JCR Journal Of Clinical Rheumatology 2021, 28: e506-e510. PMID: 34371514, DOI: 10.1097/rhu.0000000000001782.Peer-Reviewed Original ResearchConceptsVisual analog scaleMental health impactVAS scoresPediatric rheumatologistsMental healthChildhood-onset systemic lupus erythematosusCOVID-19 pandemicPrevious mental health disordersMedian current ageIdiopathic arthritis patientsSystemic lupus erythematosusHealth promotion strategiesCross-sectional studyGAD-7 scoresMental health disordersCOVID-19Health impactsCOVID-19 frontlineArthritis patientsLupus erythematosusAnalog scaleSleep abnormalitiesSevere depressionHealth disordersResponse rateA randomized controlled trial testing the efficacy of a Nurse Home Visiting Program for Pregnant Adolescents
Fatori D, Fonseca Zuccolo P, Shephard E, Brentani H, Matijasevich A, Archanjo Ferraro A, Aparecida Fracolli L, Chiesa AM, Leckman J, Constantino Miguel E, V. Polanczyk G. A randomized controlled trial testing the efficacy of a Nurse Home Visiting Program for Pregnant Adolescents. Scientific Reports 2021, 11: 14432. PMID: 34257407, PMCID: PMC8277870, DOI: 10.1038/s41598-021-93938-7.Peer-Reviewed Original ResearchConceptsWeeks of pregnancyAdolescent mothersNurse Home Visiting ProgramStandardized effect sizeChild's ageHome Visiting ProgramTrajectories of outcomesInfant Development-Third EditionEffect sizeLow-income adolescent mothersChildren's expressive language developmentAnthropometric indicesNurse homeDaily stimulationEndpoint assessmentBayley ScalesPregnant adolescentsVisiting ProgramExpressive language developmentPromising interventionChild developmentIntervention effectsPregnancyPoor urban areasAlpha frequencyPredictors of gaming disorder in children and adolescents: a school-based study
Ferreira F, Bambini B, Tonsig G, Fonseca L, Picon F, Pan P, Salum G, Jackowski A, Miguel E, Rohde L, Bressan R, Gadelha A. Predictors of gaming disorder in children and adolescents: a school-based study. Brazilian Journal Of Psychiatry 2021, 43: 289-292. PMID: 32756806, PMCID: PMC8136393, DOI: 10.1590/1516-4446-2020-0964.Peer-Reviewed Original ResearchConceptsMental disordersWell-Being Behavior AssessmentHigh-risk cohortLogistic regression modelsSchool-based studyGaming disorderPsychiatric disordersUnhealthy patternsDisorder ratesSchool-based sampleDisordersSignificant predictorsFurther riskBrazilian High-Risk CohortCommunity sampleHigh rateBehavior changeMore hoursRegression modelsChildrenPredictorsAdolescentsHoursBehavior assessmentPattern variablesDisability in children and adolescents: the extent of the impact on psychiatric disorders and educational deficits.
Zaqueu L, Teixeira M, Lowenthal R, Mari J, Miguel E, Rohde L, Paula C. Disability in children and adolescents: the extent of the impact on psychiatric disorders and educational deficits. Trends In Psychiatry And Psychotherapy 2021, 43: 235-239. PMID: 34860479, PMCID: PMC8638709, DOI: 10.47626/2237-6089-2020-0059.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderChildren/adolescentsAcademic performanceTypical developmentSchool failureType of disabilityPsychiatric disordersDeficit hyperactivity disorderEducational deficitsPoor academic performanceWorse academic performanceBrazilian children/adolescentsPresence of disabilityMental health problemsSchool-aged childrenMiddle-income countriesHyperactivity disorderSixth gradersMulticenter cross-sectional studyAdolescentsTen Questions QuestionnaireCross-sectional studyIntellectual disabilityLogistic regression modelsSpecific interventions
2020
Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents
Manfro A, Pine D, Polanczyk G, Santoro M, Smoller J, Koenen K, Mari J, Pan P, Zugman A, Schäfer J, Belangero S, Gosmann N, Simioni A, Hoexter M, Miguel E, Gadelha A, Rohde L, Salum G. Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 60: 1501-1512. PMID: 33346031, PMCID: PMC10259767, DOI: 10.1016/j.jaac.2020.11.016.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresPsychiatric diagnosisExecutive functionHigher schizophrenia polygenic risk scoresExecutive dysfunctionHigh Risk Cohort StudySmaller intracranial volumeHigher attention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorderSchizophrenia polygenic risk scoresCortical surface areaDichotomized ageCohort studyFunctional impairmentRisk scoreDomains of psychopathologyBrain regionsIntracranial volumeRelevant outcomesBrain structuresHyperactivity disorderCognitive tasksLatent class analysisLower chanceDiagnosis