2023
Gamma knife capsulotomy for intractable OCD: Neuroimage analysis of lesion size, location, and clinical response
McLaughlin N, Magnotti J, Banks G, Nanda P, Hoexter M, Lopes A, Batistuzzo M, Asaad W, Stewart C, Paulo D, Noren G, Greenberg B, Malloy P, Salloway S, Correia S, Pathak Y, Sheehan J, Marsland R, Gorgulho A, De Salles A, Miguel E, Rasmussen S, Sheth S. Gamma knife capsulotomy for intractable OCD: Neuroimage analysis of lesion size, location, and clinical response. Translational Psychiatry 2023, 13: 134. PMID: 37185805, PMCID: PMC10130137, DOI: 10.1038/s41398-023-02425-2.Peer-Reviewed Original ResearchConceptsY-BOCS reductionObsessive-compulsive disorderGamma knife capsulotomyLesion sizeRefractory obsessive-compulsive disorderOverall lesion volumeIntractable obsessive-compulsive disorderLesion-symptom mappingVoxel-wise lesion-symptom mappingClinical improvementClinical responseWhite matter pathwaysClinical outcomesFull respondersConventional therapyInternal capsuleLesion characteristicsLesion volumeAnterior limbEffective treatmentLesion locationLesion occurrenceCoronal planeSize/locationPatients
2020
Delayed Brain Cyst Formation After Gamma Knife Anterior Capsulotomy
Kasabkojian S, Dwan A, Maziero M, de Salles A, Gorgulho A, Miguel E, Fillipo de Queiroz Vattimo E, Lopes A. Delayed Brain Cyst Formation After Gamma Knife Anterior Capsulotomy. World Neurosurgery 2020, 145: 298-300. PMID: 33022431, DOI: 10.1016/j.wneu.2020.07.199.Peer-Reviewed Original ResearchConceptsRefractory obsessive-compulsive disorderAnterior capsulotomyObsessive-compulsive disorderBrain cyst formationFrontal lobe symptomsMagnetic resonance imagingAnterior frontal regionsPostoperative monthBrain cystsBrain edemaManic episodesVisual hallucinationsRadiosurgical proceduresAbnormal complicationsHigh dosesCapsulotomyResonance imagingObsessive-compulsive symptomsCyst formationEffective optionLeft hemisphereRight hemisphereFrontal regionsComplicationsSymptoms
2017
Personality measures after gamma ventral capsulotomy in intractable OCD
Paiva R, Batistuzzo M, McLaughlin N, Canteras M, de Mathis M, Requena G, Shavitt R, Greenberg B, Norén G, Rasmussen S, Tavares H, Miguel E, Lopes A, Hoexter M. Personality measures after gamma ventral capsulotomy in intractable OCD. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2017, 81: 161-168. PMID: 29100975, DOI: 10.1016/j.pnpbp.2017.10.023.Peer-Reviewed Original Research
2015
Notice of Retraction and Replacement. Lopes et al. Gamma ventral capsulotomy for obsessive-compulsive disorder: a randomized clinical trial. JAMA Psychiatry. 2014;71(9):1066-1076
Lopes A, Greenberg B, Pereira C, Norén G, Miguel E. Notice of Retraction and Replacement. Lopes et al. Gamma ventral capsulotomy for obsessive-compulsive disorder: a randomized clinical trial. JAMA Psychiatry. 2014;71(9):1066-1076. JAMA Psychiatry 2015, 72: 1258. PMID: 26509602, DOI: 10.1001/jamapsychiatry.2015.0673.Peer-Reviewed Original ResearchVisuospatial Memory Improvement after Gamma Ventral Capsulotomy in Treatment Refractory Obsessive–Compulsive Disorder Patients
Batistuzzo M, Hoexter M, Taub A, Gentil A, Cesar R, Joaquim M, D'Alcante C, McLaughlin N, Canteras M, Shavitt R, Savage C, Greenberg B, Norén G, Miguel E, Lopes A. Visuospatial Memory Improvement after Gamma Ventral Capsulotomy in Treatment Refractory Obsessive–Compulsive Disorder Patients. Neuropsychopharmacology 2015, 40: 1837-1845. PMID: 25645373, PMCID: PMC4839507, DOI: 10.1038/npp.2015.33.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRefractory OCD patientsOCD patientsVisuospatial memory performanceComprehensive neuropsychological evaluationObsessive-compulsive disorder patientsTreatment-refractory obsessive-compulsive disorder patientsCognitive flexibilityNeuropsychological domainsMemory performanceVisuospatial learningNeuropsychological functioningVisuospatial perceptionIntellectual functioningInhibitory controlRefractory obsessive-compulsive disorderTreatment-refractory OCD patientsMemory improvementGamma ventral capsulotomyMotor functioningNeuropsychological evaluationNeuropsychological outcomesEffects of GVCMotor performanceFunctioning
2014
Gamma Ventral Capsulotomy for Obsessive-Compulsive Disorder: A Randomized Clinical Trial
Lopes A, Greenberg B, Canteras M, Batistuzzo M, Hoexter M, Gentil A, Pereira C, Joaquim M, de Mathis M, D’Alcante C, Taub A, de Castro D, Tokeshi L, Sampaio L, Leite C, Shavitt R, Diniz J, Busatto G, Norén G, Rasmussen S, Miguel E. Gamma Ventral Capsulotomy for Obsessive-Compulsive Disorder: A Randomized Clinical Trial. JAMA Psychiatry 2014, 71: 1066-1076. PMID: 25054836, DOI: 10.1001/jamapsychiatry.2014.1193.Peer-Reviewed Original ResearchConceptsIntractable obsessive-compulsive disorderObsessive-compulsive disorderClinical trialsGamma ventral capsulotomyClinical Global Impressions-Improvement scaleSerious adverse eventsRandomized clinical trialsCGI-I ratingsDeep brain stimulationYale-Brown ObsessiveAdverse eventsMonth 12Additional patientsActive treatmentSham groupSymptom improvementInternal capsuleSpecialized centersNeurosurgical ablationAnterior limbMAIN OUTCOMEPsychiatric disordersPatientsOCD symptom improvementSelect cases
2010
Response to Sham and Active Gamma Ventral Capsulotomy in Otherwise Intractable Obsessive-Compulsive Disorder
Gouvea F, Lopes A, Greenberg B, Canteras M, Taub A, Mathis M, Miguel E. Response to Sham and Active Gamma Ventral Capsulotomy in Otherwise Intractable Obsessive-Compulsive Disorder. Stereotactic And Functional Neurosurgery 2010, 88: 177-182. PMID: 20431329, DOI: 10.1159/000313870.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHumansInternal CapsuleNeuropsychological TestsObsessive-Compulsive DisorderPlacebosRadiosurgeryTreatment OutcomeConceptsRefractory obsessive-compulsive disorderGamma ventral capsulotomyClinical responseSham surgeryObsessive-compulsive disorderSurgical techniquePsychopathological changesRadiosurgical proceduresRemarkable ameliorationActive interventionCompulsive disorderDisordersActive procedureCapsulotomySurgeryShamRadiosurgery
2009
Neuropsychological Outcome of Ventral CapsularVentral Striatal Gamma Capsulotomy for Refractory Obsessive-Compulsive Disorder: A Pilot Study
Taub A, Lopes A, Fuentes D, D'Alcante C, de Mathis M, Canteras M, Siviero M, Greenberg B, Norén G, Batistuzzo M, Hoexter M, Cecílio S, Savage C, Rasmussen S, Miguel E. Neuropsychological Outcome of Ventral CapsularVentral Striatal Gamma Capsulotomy for Refractory Obsessive-Compulsive Disorder: A Pilot Study. Journal Of Neuropsychiatry 2009, 21: 393-397. PMID: 19996247, DOI: 10.1176/jnp.2009.21.4.393.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderObsessive-compulsive patientsProfound cognitive deficitsAbstract reasoningNeuropsychological batteryRefractory obsessive-compulsive disorderCognitive deficitsNeuropsychological outcomesGamma knife capsulotomyMemoryVocabularyPilot studyDeficitsReasoningLearningDisordersAttentionBatteriesTreatment of Resistant Obsessive-Compulsive Disorder With Ventral CapsularVentral Striatal Gamma Capsulotomy: A Pilot Prospective Study
Lopes A, Greenberg B, Norén G, Canteras M, Busatto G, de Mathis M, Taub A, D'Alcante C, Hoexter M, Gouvea F, Cecconi J, Gentil A, Ferrão Y, Fuentes D, de Castro C, Leite C, Salvajoli J, Duran F, Rasmussen S, Miguel E. Treatment of Resistant Obsessive-Compulsive Disorder With Ventral CapsularVentral Striatal Gamma Capsulotomy: A Pilot Prospective Study. Journal Of Neuropsychiatry 2009, 21: 381-392. PMID: 19996246, DOI: 10.1176/jnp.2009.21.4.381.Peer-Reviewed Original ResearchConceptsResistant obsessive-compulsive disorderRefractory OCD patientsAdverse effectsPilot prospective studyObsessive-compulsive disorder patientsAdverse eventsProspective studyObsessive-compulsive disorderStereotactic radiosurgeryDepressive symptomsDisorder patientsSide effectsConventional treatmentCapsulotomyTherapeutic promisePatientsOCD patientsTreatmentSurgeryRadiosurgerySymptomsMonthsAssociation between symptom severity and internal capsule volume in obsessive-compulsive disorder
de Souza Duran F, Hoexter M, Valente A, Miguel E, Busatto G. Association between symptom severity and internal capsule volume in obsessive-compulsive disorder. Neuroscience Letters 2009, 452: 68-71. PMID: 19150484, DOI: 10.1016/j.neulet.2009.01.007.Peer-Reviewed Original ResearchConceptsWhite matter volumeObsessive-compulsive disorderMagnetic resonance imagingMatter volumeCingulum bundleWhite matter volume deficitsPathophysiology of OCDOCD patientsAsymptomatic control subjectsWhite matter reductionThalamic-cortical circuitWhite matter alterationsVoxel-based morphometryWhite matter tractsRegional white matter volumeSymptom severity ratingsInternal capsuleNeurosurgical treatmentSeverity scoreControl subjectsAnterior limbConnectivity dysfunctionT MRI scannerOCD severity scoresVolume deficits