2009
Higher prevalence of obsessive–compulsive spectrum disorders in rheumatic fever
de Alvarenga P, Floresi A, Torres A, Hounie A, Fossaluza V, Gentil A, Pereira C, Miguel E. Higher prevalence of obsessive–compulsive spectrum disorders in rheumatic fever. General Hospital Psychiatry 2009, 31: 178-180. PMID: 19269540, DOI: 10.1016/j.genhosppsych.2008.11.003.Peer-Reviewed Original ResearchConceptsRheumatic feverObsessive-compulsive spectrum disordersHigh prevalencePrevious historyPsychiatric outpatientsAnalytical cross-sectional studyConsecutive psychiatric outpatientsCross-sectional studySubclinical obsessive-compulsive disorderObsessive-compulsive disorderPositive historySpectrum disorderPsychiatric diagnosisMental disordersRelated disordersSenior psychiatristsObsessive-compulsive symptomsStatistical ManualDisordersPrevalencePrivate practiceFeverOutpatientsFourth EditionSuch history
2008
The Role of Group A β-Hemolytic Streptococcal Infection in Neuropsychiatric Disorders
de Alvarenga P, Hounie A, Miguel E. The Role of Group A β-Hemolytic Streptococcal Infection in Neuropsychiatric Disorders. Pediatrics 2008, 122: 1157-1157. PMID: 18978000, DOI: 10.1542/peds.2008-2118.Peer-Reviewed Original Research
2006
Association of polymorphisms within the promoter region of the tumor necrosis factor-α with clinical outcomes of rheumatic fever
Ramasawmy R, Faé K, Spina G, Victora G, Tanaka A, Palácios S, Hounie A, Miguel E, Oshiro S, Goldberg A, Kalil J, Guilherme L. Association of polymorphisms within the promoter region of the tumor necrosis factor-α with clinical outcomes of rheumatic fever. Molecular Immunology 2006, 44: 1873-1878. PMID: 17079017, DOI: 10.1016/j.molimm.2006.10.001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAortic DiseasesAutoimmune DiseasesChildChoreaCohort StudiesFemaleGenetic Predisposition to DiseaseHumansMaleMyocarditisPolymorphism, Single NucleotidePredictive Value of TestsQuantitative Trait LociRheumatic Heart DiseaseStreptococcal InfectionsStreptococcus pyogenesTumor Necrosis Factor-alphaConceptsRheumatic feverRF patientsClinical outcomesHealthy controlsTNFA geneMinor alleleRF/RHDAortic valve lesionsRecognition of autoantigensStratification of patientsTumor necrosis factorAssociation of polymorphismsMild carditisValve lesionsAdaptive armsSydenham's choreaAutoimmune diseasesHeart diseaseInflammatory diseasesNecrosis factorBorderline associationG-308APatientsImmune systemClinical phenotypeTourette's Syndrome
Shavitt R, Hounie A, Campos M, Miguel E. Tourette's Syndrome. Psychiatric Clinics Of North America 2006, 29: 471-486. PMID: 16650718, DOI: 10.1016/j.psc.2006.02.005.Peer-Reviewed Original ResearchMeSH KeywordsHumansObsessive-Compulsive DisorderRheumatic FeverStreptococcal InfectionsTourette SyndromeConceptsSerotonin reuptake inhibitorsReuptake inhibitorsLong-term side effect profileFirst-choice treatmentFirst-line optionSide effect profileCurrent treatment strategiesDorsolateral caudate nucleusPathophysiology of OCDExpression of TSTypical antipsychoticsAtypical antipsychoticsClinical manifestationsSomato-sensoryGenetic epidemiologic studiesGlobus pallidusTreatment strategiesEpidemiologic studiesCaudate nucleusTourette syndromePatient associationsRelated disordersBehavioral therapyPresence of TsSegregation analysis studiesObsessive-Compulsive Spectrum Disorders and Rheumatic Fever: A Family Study
Hounie A, Pauls D, do Rosario-Campos M, Mercadante M, Diniz J, De Mathis M, De Mathis M, Chacon P, Shavitt R, Curi M, Guilherme L, Miguel E. Obsessive-Compulsive Spectrum Disorders and Rheumatic Fever: A Family Study. Biological Psychiatry 2006, 61: 266-272. PMID: 16616727, DOI: 10.1016/j.biopsych.2006.02.021.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBacterial ProteinsCase-Control StudiesChildData Interpretation, StatisticalFamilyFemaleHumansInterview, PsychologicalLogistic ModelsMaleObserver VariationObsessive-Compulsive DisorderOdds RatioPsychiatric Status Rating ScalesRheumatic FeverRiskStreptococcal InfectionsStreptolysinsConceptsFirst-degree relativesRheumatic feverObsessive-compulsive spectrum disordersSydenham's choreaFDRs of controlsStructured psychiatric interviewUnderlying etiologic mechanismsCase-control family studyFamily studiesControl first-degree relativesBest-estimate diagnosesHigh rateRF patientsCompulsive spectrum disordersOdds ratioMorbid riskEtiologic mechanismsPsychiatric interviewSpectrum disorderLogistic regressionProbandsFeverPatientsChoreaDiagnosis