2023
Polygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample
Sato J, Biazoli C, Bueno A, Caye A, Pan P, Santoro M, Honorato‐Mauer J, Salum G, Hoexter M, Bressan R, Jackowski A, Miguel E, Belangero S, Rohde L. Polygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample. Genes Brain & Behavior 2023, 22: e12838. PMID: 36811275, PMCID: PMC10067387, DOI: 10.1111/gbb.12838.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityBrainChildConnectomeHumansMagnetic Resonance ImagingNeural PathwaysRisk FactorsConceptsCingulo-opercular networkDefault mode networkADHD-PRSAttentional networksFunctional segregationAttention-deficit/hyperactivity disorder (ADHD) symptomsAttention-deficit/hyperactivity disorderLarge-scale brain networksADHD polygenic risk scoresHyperactivity disorder symptomsSegregation of networksFunctional network segregationLongitudinal community-based cohortAttentional processesRs-fMRI dataExecutive functionHyperactivity disorderDisorder symptomsBrain networksCommunity-based sampleProbable ADHDADHDNetwork segregationPolygenic risk scoresDirection of associationAlterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents
Honorato-Mauer J, Xavier G, Ota V, Chehimi S, Mafra F, Cuóco C, Ito L, Ormond R, Asprino P, Oliveira A, Bugiga A, Torrecilhas A, Bressan R, Manfro G, Miguel E, Rohde L, Pan P, Salum G, Pellegrino R, Belangero S, Santoro M. Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents. Translational Psychiatry 2023, 13: 47. PMID: 36746925, PMCID: PMC9902559, DOI: 10.1038/s41398-023-02326-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxiety DisordersAttention Deficit Disorder with HyperactivityCohort StudiesCross-Sectional StudiesDepressionDepressive Disorder, MajorExtracellular VesiclesGenome-Wide Association StudyHumansMicroRNAsConceptsMental health disordersCross-sectional analysisMajor depressive disorderAttention-deficit/hyperactivity disorderHealth disordersAnxiety disordersExtracellular vesiclesLarge ongoing cohort studiesMiR-432-5pPeripheral extracellular vesiclesTime pointsOngoing cohort studyMiR-328-3pSerum extracellular vesiclesLongitudinal analysisWave 2Deficit/hyperactivity disorderAdolescent participantsTotal extracellular vesiclesAttention-deficit/hyperactivityMiRNA expressionCohort studyDepressive disorderMajor depressionMiR-584-5p
2022
Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways
Axelrud L, Hoffmann M, Vosberg D, Santoro M, Pan P, Gadelha A, Belangero S, Miguel E, Shin J, Thapar A, Smoller J, Pausova Z, Rohde L, Keller M, Paus T, Salum G. Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways. Journal Of Child Psychology And Psychiatry 2022, 64: 408-416. PMID: 36162806, DOI: 10.1111/jcpp.13708.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderPolygenic scoresOffspring cognitionIntergenerational transmissionMultiple mediation modelEducational attainmentBehavioral traitsCognitive measuresExecutive functionGeneral intelligenceHyperactivity disorderMediation modelMultiple mediationCognitive AssessmentCognitionPsychopathologyGenetic influencesParental educationPsychotic symptomsDirect associationParental geneticsAttainmentDiscovery sampleGenetic riskFathersInattention symptoms in early pregnancy predict parenting skills and infant maltreatment during the first year of life
de Oliveira J, Fatori D, Shephard E, Xavier M, Matijasevich A, Ferraro A, Rohde L, Chiesa A, Miguel E, Polanczyk G. Inattention symptoms in early pregnancy predict parenting skills and infant maltreatment during the first year of life. Brazilian Journal Of Psychiatry 2022, 44: 388-400. PMID: 35751597, PMCID: PMC9375657, DOI: 10.47626/1516-4446-2021-2045.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityChildChild AbuseChild RearingCognitionFemaleHumansInfantMothersParentingPregnancyConceptsMaternal attention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorderHyperactivity/impulsivity symptomsInattention symptomsImpulsivity symptomsAdolescent mothersHyperactivity disorderMaternal inattentionInfant maltreatmentEarly intervention programsParenting skillsPoor home environmentInfant developmentIntervention programsInattentionChild maltreatmentMaternal competenceMaltreatmentSkillsHome visit programHome environmentFirst yearInfant's lifeMultilevel linear regression modelsEarly pregnancy
2021
Disability in children and adolescents: the extent of the impact on psychiatric disorders and educational deficits.
Zaqueu L, Teixeira M, Lowenthal R, Mari J, Miguel E, Rohde L, Paula C. Disability in children and adolescents: the extent of the impact on psychiatric disorders and educational deficits. Trends In Psychiatry And Psychotherapy 2021, 43: 235-239. PMID: 34860479, PMCID: PMC8638709, DOI: 10.47626/2237-6089-2020-0059.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityChildCross-Sectional StudiesDisabled PersonsEducational StatusHumansMotor DisordersConceptsAttention deficit hyperactivity disorderChildren/adolescentsAcademic performanceTypical developmentSchool failureType of disabilityPsychiatric disordersDeficit hyperactivity disorderEducational deficitsPoor academic performanceWorse academic performanceBrazilian children/adolescentsPresence of disabilityMental health problemsSchool-aged childrenMiddle-income countriesHyperactivity disorderSixth gradersMulticenter cross-sectional studyAdolescentsTen Questions QuestionnaireCross-sectional studyIntellectual disabilityLogistic regression modelsSpecific interventions
2020
Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents
Manfro A, Pine D, Polanczyk G, Santoro M, Smoller J, Koenen K, Mari J, Pan P, Zugman A, Schäfer J, Belangero S, Gosmann N, Simioni A, Hoexter M, Miguel E, Gadelha A, Rohde L, Salum G. Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 60: 1501-1512. PMID: 33346031, PMCID: PMC10259767, DOI: 10.1016/j.jaac.2020.11.016.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityBrazilCell Adhesion MoleculesChildCognitive DysfunctionCohort StudiesExecutive FunctionHumansIntelligenceNeuropsychological TestsSchizophreniaConceptsPolygenic risk scoresPsychiatric diagnosisExecutive functionHigher schizophrenia polygenic risk scoresExecutive dysfunctionHigh Risk Cohort StudySmaller intracranial volumeHigher attention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorderSchizophrenia polygenic risk scoresCortical surface areaDichotomized ageCohort studyFunctional impairmentRisk scoreDomains of psychopathologyBrain regionsIntracranial volumeRelevant outcomesBrain structuresHyperactivity disorderCognitive tasksLatent class analysisLower chanceDiagnosis
2019
Relative Age and Attention-Deficit/Hyperactivity Disorder: Data From Three Epidemiological Cohorts and a Meta-analysis
Caye A, Petresco S, de Barros A, Bressan R, Gadelha A, Gonçalves H, Manfro A, Matijasevich A, Menezes A, Miguel E, Munhoz T, Pan P, Salum G, Santos I, Kieling C, Rohde L. Relative Age and Attention-Deficit/Hyperactivity Disorder: Data From Three Epidemiological Cohorts and a Meta-analysis. Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 59: 990-997. PMID: 31442562, DOI: 10.1016/j.jaac.2019.07.939.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityBrazilChildChild, PreschoolCohort StudiesHumansRiskConceptsYounger ageADHD diagnosisMeta-AnalysisADHD symptomsPelotas cohortCommunity-based cohortPopulation-based cohortAttention-deficit/hyperactivity disorderHigh-risk studiesRelative young ageAttention-deficit/hyperactivity disorder (ADHD) symptomsWeb of ScienceHyperactivity disorder symptomsEpidemiology guidelinesEligible recordsRelative riskObservational studyHigh riskPsychiatric disordersEpidemiological cohortCohortSymptomsDiagnosisEffect estimatesHyperactivity disorderEffects of Maternal Psychopathology and Education Level on Neurocognitive Development in Infants of Adolescent Mothers Living in Poverty in Brazil
Shephard E, Fatori D, Mauro L, de Medeiros Filho M, Hoexter M, Chiesa A, Fracolli L, Brentani H, Ferraro A, Nelson C, Miguel E, Polanczyk G. Effects of Maternal Psychopathology and Education Level on Neurocognitive Development in Infants of Adolescent Mothers Living in Poverty in Brazil. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 4: 925-934. PMID: 31345780, PMCID: PMC6863387, DOI: 10.1016/j.bpsc.2019.05.009.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxietyAnxiety DisordersAttentionAttention Deficit Disorder with HyperactivityBrazilChild DevelopmentDepressionDepressive DisorderFemaleHumansInfantMothersPilot ProjectsPsychopathologyYoung AdultConceptsLow maternal educationMaternal psychopathologyAttention-deficit/hyperactivity disorderMaternal anxietyNeurocognitive developmentInfant neurodevelopmentAdolescent mothersMaternal educationHyperactivity disorderInfant neurocognitive developmentMonths of ageResting-state electroencephalographyCluster-based permutation testingEducation levelOscillatory powerEarly brain developmentMaternal symptomsRisk factorsConnectivity alterationsEarly neurocognitive developmentOscillatory connectivityRelative theta powerFunctional connectivityBrain developmentPilot studyThe impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects
Blanco‐Vieira T, Santos M, Ferrão YA, Torres AR, Miguel EC, Bloch MH, Leckman JF, do Rosario MC. The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects. Depression And Anxiety 2019, 36: 533-542. PMID: 30990937, DOI: 10.1002/da.22898.Peer-Reviewed Original ResearchMeSH KeywordsAcademic SuccessAdolescentAdultAgedAged, 80 and overAttention Deficit Disorder with HyperactivityBrazilComorbidityCorrelation of DataCross-Sectional StudiesFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPhenotypePrevalenceSuicide, AttemptedTourette SyndromeYoung AdultConceptsAttention deficit hyperactivity disorderAdult OCD patientsObsessive-compulsive disorderDeficit hyperactivity disorderOCD patientsClinical characteristicsExact testFeatures of ADHDHyperactivity disorderSubgroup of patientsAdult obsessive-compulsive disorderComorbid attention deficit hyperactivity disorderSpecific clinical featuresCross-sectional studyObsessive-compulsive disorder (OCD) subjectsLogistic regression analysisFisher's exact testBrazilian Research ConsortiumMann-Whitney testAdult patientsRheumatic feverDevelopment of interventionsClinical featuresObsessive-compulsive spectrum disordersLifetime prevalence
2017
Prevalence, clinical correlates and maternal psychopathology of deliberate self-harm in children and early adolescents: results from a large community study
Simioni A, Pan P, Gadelha A, Manfro G, Mari J, Miguel E, Rohde L, Salum G. Prevalence, clinical correlates and maternal psychopathology of deliberate self-harm in children and early adolescents: results from a large community study. Brazilian Journal Of Psychiatry 2017, 40: 48-55. PMID: 28832748, PMCID: PMC6899416, DOI: 10.1590/1516-4446-2016-2124.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxiety DisordersAttention Deficit Disorder with HyperactivityBrazilChildCohort StudiesDepressionFemaleHumansMaleMaternal BehaviorPrevalencePsychopathologyRisk FactorsSelf-Injurious BehaviorSocioeconomic FactorsSuicide, AttemptedConceptsAttention-deficit/hyperactivity disorderOppositional defiant disorderMaternal psychopathologyPsychiatric disordersClinical diagnosisCo-occurring psychiatric disordersAnxiety disordersHigh Risk Cohort StudyCommunity-based studyDiagnosis of depressionMaternal mood disordersMaternal anxiety disordersPotential confounding factorsLarge community studyChildhood psychiatric disordersChild's clinical diagnosisPrevalence of DSHCohort studyMiddle-income countriesClinical correlatesMood disordersPrevalence estimatesConfounding factorsAge groupsLogistic regressionComparability of an ADHD Latent Trait Between Groups: Disentangling True Between-Group Differences From Measurement Problems
Cogo-Moreira H, Lúcio P, Swardfager W, Gadelha A, de Jesus Mari J, Miguel E, Rohde L, Salum G. Comparability of an ADHD Latent Trait Between Groups: Disentangling True Between-Group Differences From Measurement Problems. Journal Of Attention Disorders 2017, 23: 712-720. PMID: 28478691, DOI: 10.1177/1087054717707047.Peer-Reviewed Original ResearchAdolescentAge FactorsAttentionAttention Deficit Disorder with HyperactivityChildCohort StudiesEducational StatusFactor Analysis, StatisticalFemaleHumansImpulsive BehaviorIntelligenceMaleMothersPsychomotor AgitationSex Factors
2016
Measuring child maltreatment using multi-informant survey data: a higher-order confirmatory factor analysis
Salum G, DeSousa D, Manfro G, Pan P, Gadelha A, Brietzke E, Miguel E, Mari J, do Rosário M, Grassi-Oliveira R. Measuring child maltreatment using multi-informant survey data: a higher-order confirmatory factor analysis. Trends In Psychiatry And Psychotherapy 2016, 38: 23-32. PMID: 27007940, DOI: 10.1590/2237-6089-2015-0036.Peer-Reviewed Original ResearchMeSH KeywordsAnxiety DisordersAttention Deficit Disorder with HyperactivityBrazilChildChild AbuseConduct DisorderData Interpretation, StatisticalFactor Analysis, StatisticalFemaleHumansMaleParentsReproducibility of ResultsSchoolsStress Disorders, TraumaticSurveys and QuestionnairesConceptsConfirmatory factor analysisChild maltreatmentOppositional defiant disorder/conduct disorderAttention deficit hyperactivity disorderHigher-order confirmatory factor analysisMulti-informant approachDeficit hyperactivity disorderLower-order factorsLarge community sampleMulti-informant survey dataHigher-order factorsFactor analysisMeasures of psychopathologyTeacher-reported scoresOverall child maltreatmentFear disordersProsocial measuresHyperactivity disorderBrief measureDistress disordersCommunity sampleConduct disorderEmotional abuseDivergent validitySexual abuseAn integrative approach to investigate the respective roles of single-nucleotide variants and copy-number variants in Attention-Deficit/Hyperactivity Disorder
de Araújo Lima L, Feio-dos-Santos A, Belangero S, Gadelha A, Bressan R, Salum G, Pan P, Moriyama T, Graeff-Martins A, Tamanaha A, Alvarenga P, Krieger F, Fleitlich-Bilyk B, Jackowski A, Brietzke E, Sato J, Polanczyk G, Mari J, Manfro G, do Rosário M, Miguel E, Puga R, Tahira A, Souza V, Chile T, Gouveia G, Simões S, Chang X, Pellegrino R, Tian L, Glessner J, Hashimoto R, Rohde L, Sleiman P, Hakonarson H, Brentani H. An integrative approach to investigate the respective roles of single-nucleotide variants and copy-number variants in Attention-Deficit/Hyperactivity Disorder. Scientific Reports 2016, 6: 22851. PMID: 26947246, PMCID: PMC4780010, DOI: 10.1038/srep22851.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityBrainBrazilChildCohort StudiesComputational BiologyComputer SimulationDNA Copy Number VariationsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMalePolymorphism, Single NucleotideProtein Interaction MappingConceptsCopy number variantsProtein-protein interaction networkDe novo CNVsSingle nucleotide variantsGenetic architectureNew genesInteraction networksOnly geneFunctional analysisCNV studiesNovo CNVsGenesCell adhesionGenetic variantsExome dataIntegrative approachPathwayGenetic susceptibilityVariantsGWASTriosRespective rolesSilicoCNVsSNVs
2012
Attention deficit disorder/hyperactivity: a scientific overview
Polanczyk G, Casella E, Miguel E, Reed U. Attention deficit disorder/hyperactivity: a scientific overview. Clinics 2012, 67: 1125-1126. PMID: 23070336, PMCID: PMC3460012, DOI: 10.6061/clinics/2012(10)01.Peer-Reviewed Original Research
2008
Obsessive–compulsive disorder: Influence of age at onset on comorbidity patterns
de Mathis M, do Rosario M, Diniz J, Torres A, Shavitt R, Ferrão Y, Fossaluza V, de Bragança Pereira C, Miguel E. Obsessive–compulsive disorder: Influence of age at onset on comorbidity patterns. European Psychiatry 2008, 23: 187-194. PMID: 18329252, DOI: 10.1016/j.eurpsy.2008.01.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAnxiety DisordersAttention Deficit Disorder with HyperactivityBrazilComorbidityCross-Sectional StudiesDisruptive, Impulse Control, and Conduct DisordersFeeding and Eating DisordersFemaleHumansMaleMental DisordersMiddle AgedObsessive-Compulsive DisorderPersonality AssessmentSex FactorsSomatoform DisordersTic DisordersConceptsImpulse control disordersInfluence of ageComorbidity patternsYale Global Tic Severity ScaleOCD patientsStructured Clinical InterviewTic Severity ScaleYale-Brown Obsessive Compulsive ScaleAttention-deficit/hyperactivity disorderObsessive Compulsive ScalePsychiatric comorbidityIllness durationTic disordersFemale genderSeverity ScaleClinical InterviewDSM-IVLower ageAnxiety disordersCompulsive ScaleHyperactivity disorderDisordersLower chanceAgeComorbidities
2001
Síndrome de Gilles de la Tourette: estudo clínico de 58 casos
Chien H, Barbosa E, Miguel E. Síndrome de Gilles de la Tourette: estudo clínico de 58 casos. Arquivos De Neuro-Psiquiatria 2001, 59: 729-732. PMID: 11593274, DOI: 10.1590/s0004-282x2001000500015.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionAge of OnsetAttention Deficit Disorder with HyperactivityBrazilChildFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderTic DisordersTourette SyndromeConceptsGilles de la Tourette's syndromeGilles de la TouretteLa Tourette's syndromeAge of onsetObsessive-compulsive disorderFemale ratioInitial symptomsMotor ticsVocal ticsChildhood onsetAssociated manifestationsComplex ticsTourette syndromePatientsNeuropsychiatric disordersHyperactivity disorderAge rangeAttention deficitsDisordersSyndromeSensory phenomenaOnsetYearsCopropraxiaLa Tourette
2000
The Psychiatric Symptoms of Rheumatic Fever
Mercadante MT, Busatto GF, Lombroso PJ, Prado L, Rosário-Campos MC, do Valle R, Marques-Dias MJ, Kiss MH, Leckman JF, Miguel EC. The Psychiatric Symptoms of Rheumatic Fever. American Journal Of Psychiatry 2000, 157: 2036-2038. PMID: 11097972, DOI: 10.1176/appi.ajp.157.12.2036.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAge of OnsetAttention Deficit Disorder with HyperactivityBrazilChildChoreaComorbidityDepressive DisorderFemaleHumansMaleMental DisordersObsessive-Compulsive DisorderPrevalencePsychiatric Status Rating ScalesRheumatic FeverTicsConceptsAttention deficit hyperactivity disorderRheumatic feverSydenham's choreaTic disordersHigh riskComparison groupFever groupMajor depressive disorderDeficit hyperactivity disorderObsessive-compulsive disorderDepressive disorderRisk factorsPsychiatric symptomsPsychiatric disordersChoreaFeverNeuropsychiatric disordersObsessive-compulsive symptomsRating ScaleHyperactivity disorderSymptomsDisordersADHD symptomsChildrenSemistructured interviews