2022
Factor structure of the Dimensional Yale-Brown Obsessive-Compulsive Scale in a large sample of adults with obsessive-compulsive disorder
Batistuzzo M, Fontenelle L, Ferrão Y, Rosário M, Miguel E, Fatori D. Factor structure of the Dimensional Yale-Brown Obsessive-Compulsive Scale in a large sample of adults with obsessive-compulsive disorder. Brazilian Journal Of Psychiatry 2022, 44: 57-60. PMID: 34878003, PMCID: PMC8827375, DOI: 10.1590/1516-4446-2021-2088.Peer-Reviewed Original Research
2020
Social losses predict a faster onset and greater severity of obsessive-compulsive disorder
Destrée L, Albertella L, Torres A, Ferrão Y, Shavitt R, Miguel E, Fontenelle L. Social losses predict a faster onset and greater severity of obsessive-compulsive disorder. Journal Of Psychiatric Research 2020, 130: 187-193. PMID: 32828024, DOI: 10.1016/j.jpsychires.2020.07.027.Peer-Reviewed Original ResearchConceptsClinical obsessive-compulsive disorderObsessive-compulsive disorderStressful life eventsSpeed of progressionYale-Brown ObsessiveDSM-IV Axis I DisordersLife eventsCompulsive ScaleAxis I DisordersStructured Clinical InterviewSeverity of symptomsSymptom dimensionsBeck Depression InventorySubclinical obsessive-compulsive symptomsBeck Anxiety InventorySpecific obsessive-compulsive symptom dimensionsI disordersFaster onsetPsychiatric disordersHistory questionnaireBrown AssessmentClinical InterviewGreater severityDepression InventoryObsessive-compulsive symptomsIs it time to change the gold standard of obsessive-compulsive disorder severity assessment? Factor structure of the Yale-Brown Obsessive-Compulsive Scale
Fatori D, Costa D, Asbahr F, Ferrão Y, Rosário M, Miguel E, Shavitt R, Batistuzzo M. Is it time to change the gold standard of obsessive-compulsive disorder severity assessment? Factor structure of the Yale-Brown Obsessive-Compulsive Scale. Australian & New Zealand Journal Of Psychiatry 2020, 54: 732-742. PMID: 32475123, DOI: 10.1177/0004867420924113.Peer-Reviewed Original Research
2017
Quantifying dimensional severity of obsessive-compulsive disorder for neurobiological research
Shavitt R, Requena G, Alonso P, Zai G, Costa D, de Bragança Pereira C, do Rosário M, Morais I, Fontenelle L, Cappi C, Kennedy J, Menchon J, Miguel E, Richter P. Quantifying dimensional severity of obsessive-compulsive disorder for neurobiological research. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2017, 79: 206-212. PMID: 28673486, DOI: 10.1016/j.pnpbp.2017.06.037.Peer-Reviewed Original ResearchSpecific and social fears in children and adolescents: separating normative fears from problem indicators and phobias
Laporte P, Pan P, Hoffmann M, Wakschlag L, Rohde L, Miguel E, Pine D, Manfro G, Salum G. Specific and social fears in children and adolescents: separating normative fears from problem indicators and phobias. Brazilian Journal Of Psychiatry 2017, 39: 118-125. PMID: 28300935, PMCID: PMC7111439, DOI: 10.1590/1516-4446-2016-2064.Peer-Reviewed Original Research
2016
Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive–compulsive disorder
Cappi C, Diniz J, Requena G, Lourenço T, Lisboa B, Batistuzzo M, Marques A, Hoexter M, Pereira C, Miguel E, Brentani H. Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive–compulsive disorder. BMC Neuroscience 2016, 17: 79. PMID: 27903255, PMCID: PMC5131547, DOI: 10.1186/s12868-016-0313-4.Peer-Reviewed Original ResearchPrevalence and correlates of electroconvulsive therapy delivery in 1001 obsessive-compulsive disorder outpatients
dos Santos-Ribeiro S, Lins-Martins N, Frydman I, do Rosário M, Ferrão Y, Shavitt R, Yücel M, Miguel E, Fontenelle L. Prevalence and correlates of electroconvulsive therapy delivery in 1001 obsessive-compulsive disorder outpatients. Psychiatry Research 2016, 239: 145-148. PMID: 27137976, DOI: 10.1016/j.psychres.2016.03.020.Peer-Reviewed Original ResearchConceptsElectroconvulsive therapyObsessive-compulsive disorderOCD patientsHigher global severitySerotonin reuptake inhibitorsObsessive-compulsive disorder outpatientsContamination/washing symptomsRates of psychosisDifferent specialized centersAdequate trialReuptake inhibitorsSpecialized centersGlobal severityGreater suicidalityDisorder outpatientsTherapy deliveryTerms of responseAssessment BatteryPatientsOCD symptomsSymptomsWashing symptomsAntipsychoticsOutpatientsTherapy
2015
Defining clinical severity in adults with obsessive–compulsive disorder
Storch E, De Nadai A, do Rosário M, Shavitt R, Torres A, Ferrão Y, Miguel E, Lewin A, Fontenelle L. Defining clinical severity in adults with obsessive–compulsive disorder. Comprehensive Psychiatry 2015, 63: 30-35. PMID: 26555489, PMCID: PMC4643407, DOI: 10.1016/j.comppsych.2015.08.007.Peer-Reviewed Original Research
2014
Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette’s Syndrome and OCD
Yu D, Mathews CA, Scharf JM, Neale BM, Davis LK, Gamazon ER, Derks EM, Evans P, Edlund CK, Crane J, Fagerness JA, Osiecki L, Gallagher P, Gerber G, Haddad S, Illmann C, McGrath LM, Mayerfeld C, Arepalli S, Barlassina C, Barr CL, Bellodi L, Benarroch F, Berrió GB, Bienvenu OJ, Black DW, Bloch MH, Brentani H, Bruun RD, Budman CL, Camarena B, Campbell DD, Cappi C, Silgado JC, Cavallini MC, Chavira DA, Chouinard S, Cook EH, Cookson MR, Coric V, Cullen B, Cusi D, Delorme R, Denys D, Dion Y, Eapen V, Egberts K, Falkai P, Fernandez T, Fournier E, Garrido H, Geller D, Gilbert DL, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Hardy J, Heiman GA, Hemmings SM, Herrera LD, Hezel DM, Hoekstra PJ, Jankovic J, Kennedy JL, King RA, Konkashbaev AI, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Lupoli S, Macciardi F, Maier W, Manunta P, Marconi M, McCracken JT, Mesa Restrepo SC, Moessner R, Moorjani P, Morgan J, Muller H, Murphy DL, Naarden AL, Nurmi E, Ochoa WC, Ophoff RA, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner T, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosário MC, Rosenberg D, Ruhrmann S, Sabatti C, Salvi E, Sampaio AS, Samuels J, Sandor P, Service SK, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Turiel M, Valencia Duarte AV, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Weale M, Weiss R, Wendland JR, Westenberg HG, Shugart YY, Hounie AG, Miguel EC, Nicolini H, Wagner M, Ruiz-Linares A, Cath DC, McMahon W, Posthuma D, Oostra BA, Nestadt G, Rouleau GA, Purcell S, Jenike MA, Heutink P, Hanna GL, Conti DV, Arnold PD, Freimer NB, Stewart SE, Knowles JA, Cox NJ, Pauls DL. Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette’s Syndrome and OCD. American Journal Of Psychiatry 2014, 172: 82-93. PMID: 25158072, PMCID: PMC4282594, DOI: 10.1176/appi.ajp.2014.13101306.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesSingle nucleotide polymorphismsPolygenic score analysisGene expression levelsGenetic architecturePhenotypic varianceCombined genome-wide association studyFunctional variantsPolygenic componentPolygenic signalSignificant polygenic componentExpression levelsGWAS summary statisticsAncestry-matched controlsBrain gene expression levelsComplex genetic relationshipsHeritable neurodevelopmental disorderTrue functional variantsParent-child triosGWAS signalsIndividual single nucleotide polymorphismsWide analysisGenetic variationUnderlying genetic susceptibilityAssociation studiesHoarding symptoms and prediction of poor response to limbic system surgery for treatment-refractory obsessive-compulsive disorder.
Gentil AF, Lopes AC, Dougherty DD, Rück C, Mataix-Cols D, Lukacs TL, Canteras MM, Eskandar EN, Larsson KJ, Hoexter MQ, Batistuzzo MC, Greenberg BD, Miguel EC. Hoarding symptoms and prediction of poor response to limbic system surgery for treatment-refractory obsessive-compulsive disorder. Journal Of Neurosurgery 2014, 121: 123-30. PMID: 24702323, DOI: 10.3171/2014.2.jns131423.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedFemaleHoarding DisorderHumansLimbic SystemMaleMiddle AgedObsessive-Compulsive DisorderPsychosurgerySeverity of Illness IndexTreatment OutcomeYoung AdultConceptsLimbic system surgeryClinical outcomesWorse responseMean Y-BOCS scoreTreatment-refractory obsessive-compulsive disorderSymptom dimensionsPreoperative symptom severityWorse clinical outcomesTreatment-refractory patientsY-BOCS scoresYale-Brown Obsessive Compulsive ScaleSymptom Checklist scoresHoarding dimensionObsessive Compulsive ScaleSurgery needObsessive-compulsive disorderSurgical modalitiesAblative surgeryPoor responseWorse outcomesTreatment outcomesDimensional Yale-Brown Obsessive Compulsive ScaleYBOCS scoresPatientsSurgery
2013
Predicting obsessive–compulsive disorder severity combining neuroimaging and machine learning methods
Hoexter M, Miguel E, Diniz J, Shavitt R, Busatto G, Sato J. Predicting obsessive–compulsive disorder severity combining neuroimaging and machine learning methods. Journal Of Affective Disorders 2013, 150: 1213-1216. PMID: 23769292, DOI: 10.1016/j.jad.2013.05.041.Peer-Reviewed Original Research
2012
Obsessive-compulsive symptom dimensions correlate to specific gray matter volumes in treatment-naïve patients
Alvarenga P, do Rosário M, Batistuzzo M, Diniz J, Shavitt R, Duran F, Dougherty D, Bressan R, Miguel E, Hoexter M. Obsessive-compulsive symptom dimensions correlate to specific gray matter volumes in treatment-naïve patients. Journal Of Psychiatric Research 2012, 46: 1635-1642. PMID: 23040160, DOI: 10.1016/j.jpsychires.2012.09.002.Peer-Reviewed Original ResearchClinical correlates of social adjustment in patients with obsessive-compulsive disorder
Rosa A, Diniz J, Fossaluza V, Torres A, Fontenelle L, De Mathis A, da Conceição Rosário M, Miguel E, Shavitt R. Clinical correlates of social adjustment in patients with obsessive-compulsive disorder. Journal Of Psychiatric Research 2012, 46: 1286-1292. PMID: 22800713, DOI: 10.1016/j.jpsychires.2012.05.019.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPoor social adjustmentSocial adjustmentSocial functioningOverall social functioningYale-Brown ObsessiveOCD severityReligious obsessionsCompulsive ScaleCurrent post-traumatic stress disorderSpecific OCD symptomsPost-traumatic stress disorderPrimary DSM-IV diagnosisOCD symptom onsetPoor social functioningSocial adjustment measuresObsessive-compulsive spectrum disordersGreater OCD severitySocial Adjustment ScaleBrazilian Research ConsortiumPoorer overall social functioningDimensional Yale-Brown ObsessivePsychiatric comorbidityCurrent psychiatric comorbidityCurrent major depressive disorder‘Impulsive compulsivity’ in obsessive-compulsive disorder: A phenotypic marker of patients with poor clinical outcome
Kashyap H, Fontenelle L, Miguel E, Ferrão Y, Torres A, Shavitt R, Ferreira-Garcia R, do Rosário M, Yücel M. ‘Impulsive compulsivity’ in obsessive-compulsive disorder: A phenotypic marker of patients with poor clinical outcome. Journal Of Psychiatric Research 2012, 46: 1146-1152. PMID: 22647523, DOI: 10.1016/j.jpsychires.2012.04.022.Peer-Reviewed Original ResearchClinical features of obsessive-compulsive disorder with hoarding symptoms: A multicenter study
Torres A, Fontenelle L, Ferrão Y, do Rosário M, Torresan R, Miguel E, Shavitt R. Clinical features of obsessive-compulsive disorder with hoarding symptoms: A multicenter study. Journal Of Psychiatric Research 2012, 46: 724-732. PMID: 22464941, DOI: 10.1016/j.jpsychires.2012.03.005.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderClinical featuresOCD patientsLogistic regressionDSM-IV OCD patientsCertain clinical featuresCross-sectional studyAttention-deficit/hyperactivity disorderStatistical univariate analysisBrazilian Research ConsortiumDeficit/hyperactivity disorderHigher anxiety scoresYale-Brown ObsessiveSymptom onsetInsidious onsetMulticenter studyObsessive-compulsive spectrum disordersSectional studyPossible confoundersUnivariate analysisTic disordersHoarding dimensionPatientsSymptomsPoor insightSensory phenomena associated with repetitive behaviors in obsessive-compulsive disorder: An exploratory study of 1001 patients
Ferrão Y, Shavitt R, Prado H, Fontenelle L, Malavazzi D, de Mathis M, Hounie A, Miguel E, do Rosário M. Sensory phenomena associated with repetitive behaviors in obsessive-compulsive disorder: An exploratory study of 1001 patients. Psychiatry Research 2012, 197: 253-258. PMID: 22361443, DOI: 10.1016/j.psychres.2011.09.017.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSensory phenomenaOCD patientsConsecutive OCD patientsPresence/severityLogistic regression analysisFrequency/severityClinical characteristicsTic disordersFamily historyRepetitive behaviorsPatientsTourette syndromeGreater severityPsychopathological aspectsLevel of insightSeverityDisordersSymptom dimensionsRegression analysisFurther investigationSubstantial numberOC symptomsSymmetry/
2011
Towards a post-traumatic subtype of obsessive–compulsive disorder
Fontenelle L, Cocchi L, Harrison B, Shavitt R, do Rosário M, Ferrão Y, de Mathis M, Cordioli A, Yücel M, Pantelis C, de Jesus Mari J, Miguel E, Torres A. Towards a post-traumatic subtype of obsessive–compulsive disorder. Journal Of Anxiety Disorders 2011, 26: 377-383. PMID: 22230220, DOI: 10.1016/j.janxdis.2011.12.001.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderObsessive-compulsive symptomsOCD patientsPost-traumatic stress disorderOnset of OCDCompulsive buying disorderHistory of PTSDTraumatic eventsStress disorderBuying disorderOCD onsetPanic disorderPTSDAlcohol-related disordersClinical featuresDisordersEducational levelMultinomial logistic regression analysisLogistic regression analysisSuicide planEarly ageLow educational levelMiscellaneous symptomsLater ageRegression analysis
2010
Comorbid major depression in obsessive-compulsive disorder patients
Quarantini L, Torres A, Sampaio A, Fossaluza V, de Mathis M, do Rosário M, Fontenelle L, Ferrão Y, Cordioli A, Petribu K, Hounie A, Miguel E, Shavitt R, Koenen K. Comorbid major depression in obsessive-compulsive disorder patients. Comprehensive Psychiatry 2010, 52: 386-393. PMID: 21087765, DOI: 10.1016/j.comppsych.2010.09.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrazilComorbidityDepressive Disorder, MajorFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPrevalenceSeverity of Illness IndexConceptsMajor depressive disorderObsessive-compulsive disorderOCD patientsCurrent major depressive disorderComorbid major depressive disorderLifetime major depressive disorderComprehensive psychiatric evaluationComorbid major depressionSevere general psychopathologyHigher severity scoresObsessive-compulsive disorder patientsSymptom dimensionsOCD symptom dimensionsClinical characteristicsFrequent complicationSeverity scoreDepressive disorderMajor depressionPrevalence ratesPsychiatric evaluationDisorder patientsPatientsGeneral psychopathologyDisordersOCD symptomsObsessive-compulsive disorder and its related disorders: a reappraisal of obsessive-compulsive spectrum concepts
Murphy D, Timpano K, Wheaton M, Greenberg B, Miguel E. Obsessive-compulsive disorder and its related disorders: a reappraisal of obsessive-compulsive spectrum concepts. Dialogues In Clinical Neuroscience 2010, 12: 131-148. PMID: 20623919, PMCID: PMC3181955, DOI: 10.31887/dcns.2010.12.2/dmurphy.Peer-Reviewed Original Research
2009
Early Onset Obsessive-Compulsive Disorder With and Without Tics
de Mathis M, Diniz J, Shavitt R, Torres A, Ferrão Y, Fossaluza V, Pereira C, Miguel E, do Rosario M. Early Onset Obsessive-Compulsive Disorder With and Without Tics. CNS Spectrums 2009, 14: 362-370. PMID: 19773712, DOI: 10.1017/s1092852900023014.Peer-Reviewed Original ResearchConceptsOnset obsessive-compulsive disorderObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleYears of ageEarly-onset obsessive-compulsive disorderObsessive Compulsive ScaleObsessive-compulsive symptomsTic disordersDimensional Yale-Brown Obsessive Compulsive ScaleYale Global Tic Severity ScaleCompulsive ScaleHigher mean scoresFourth Edition criteriaStructured Clinical InterviewTic Severity ScaleVariable clinical manifestationsMean score