2024
Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure
Vriend C, de Joode N, Pouwels P, Liu F, Otaduy M, Pastorello B, Robertson F, Ipser J, Lee S, Hezel D, van Meter P, Batistuzzo M, Hoexter M, Sheshachala K, Narayanaswamy J, Venkatasubramanian G, Lochner C, Miguel E, Reddy Y, Shavitt R, Stein D, Wall M, Simpson H, van den Heuvel O. Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure. Molecular Psychiatry 2024, 29: 1033-1045. PMID: 38228890, PMCID: PMC11176057, DOI: 10.1038/s41380-023-02390-8.Peer-Reviewed Original ResearchObsessive-compulsive disorderPathophysiology of obsessive-compulsive disorderObsessive-compulsive disorder groupAge of OCD onsetOCD onsetHealthy controlsMedication-free adultsWhite matter microstructural alterationsVisual attention processesWhite matter microstructureStructural brain networksStructural connectome analysisWhite matter tractsBayesian multilevel analysisDirection of effectAttentional processesOCD individualsBrain signaturesBrain networksDiffusion MRI studiesPost hoc analysisSagittal stratumConnectome analysisMultilevel analysisStructural connectome
2016
Children with Poor Reading Skills at the Word Level Show Reduced Fractional Anisotropy in White Matter Tracts of Both Hemispheres
de Moura L, Cogo-Moreira H, de Ávila C, Pan P, Gadelha A, Moriyama T, Del Aquilla M, Hoexter M, Salum G, Picon F, Anés M, Mercadante M, Lacerda A, Amaro E, Miguel E, Rohde L, Bressan R, McGuire P, Sato J, de Jesus Mari J, Jackowski A. Children with Poor Reading Skills at the Word Level Show Reduced Fractional Anisotropy in White Matter Tracts of Both Hemispheres. Brain Connectivity 2016, 6: 519-523. PMID: 27353747, DOI: 10.1089/brain.2016.0430.Peer-Reviewed Original ResearchConceptsWhite matter tractsRadial diffusivityDiffusion tensor imaging studyLatent class analysisSignificant fractional anisotropy reductionYears of ageReduced fractional anisotropyFractional anisotropy reductionsMultiple cortical regionsWhite matter microstructureWhite matterWidespread structural alterationsCortical regionsImaging studiesFractional anisotropyLeft hemisphereTract