2023
W27. POLYGENIC RISK SCORE AND HOUSEHOLD DEPRIVATION ARE RELATED TO INTERNALIZING SYMPTOMS IN YOUTH
Belangero S, De Oliveira A, Carvalho C, Ota V, Bugiga A, Pan P, Mauer J, Mari J, Santoro M, Miguel E, Hoffmann M, Salum G. W27. POLYGENIC RISK SCORE AND HOUSEHOLD DEPRIVATION ARE RELATED TO INTERNALIZING SYMPTOMS IN YOUTH. European Neuropsychopharmacology 2023, 75: s118-s119. DOI: 10.1016/j.euroneuro.2023.08.217.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsLinear mixed modelsMental disordersHigh Risk Cohort StudyInternalizing symptomsWell-Being AssessmentPotential biological markersParent reportGenome-wide association studiesSelf-report measuresTraumatic eventsCohort studyHigh prevalenceRisk scoreGene-environment interactionsPsychiatric disordersInternalizing psychopathologySignificant associationSymptomsBiological markersUnderlying causeHousehold deprivationScore studyInternalizing problemsEarly life
2021
Childhood poverty and mental health disorders in early adulthood: evidence from a Brazilian cohort study
Ziebold C, Evans-Lacko S, Andrade M, Hoffmann M, Fonseca L, Barbosa M, Pan P, Miguel E, Bressan R, Rohde L, Salum G, Schafer J, de Jesus Mari J, Gadelha A. Childhood poverty and mental health disorders in early adulthood: evidence from a Brazilian cohort study. European Child & Adolescent Psychiatry 2021, 32: 903-914. PMID: 34853911, DOI: 10.1007/s00787-021-01923-2.Peer-Reviewed Original ResearchConceptsMental health disordersStressful life eventsEarly adulthoodHealth disordersPreventable risk factorsDifferent stressful life eventsInternalizing disordersBrazilian cohort studyProspective community cohortWell-Being AssessmentCohort studyCommunity cohortRisk factorsStratified analysisPsychiatric diagnosisExternalizing disordersChildhood povertyDisordersBaselineAdulthoodStandardized classificationHigh exposureLife eventsAssociationYoung people
2019
SA72 GENE EXPRESSION IN BLOOD OF ADOLESCENTS WITH PSYCHIATRIC DISORDERS
Spindola L, Santoro M, Pan P, Talarico F, Xavier G, Carvalho C, Gadelha A, Salum G, Miguel E, Rohde L, Zanardo E, Kulikowski L, Bressan R, Ota V, Belangero S. SA72 GENE EXPRESSION IN BLOOD OF ADOLESCENTS WITH PSYCHIATRIC DISORDERS. European Neuropsychopharmacology 2019, 29: s861. DOI: 10.1016/j.euroneuro.2017.08.144.Peer-Reviewed Original ResearchHigh-risk cohortPsychiatric disordersHealthy controlsGene expression profilingChild Behavior ChecklistEarly-onset psychiatric disordersBlood of adolescentsPrevious psychiatric disorderBlood gene expression profilingCross-sectional studyOnset psychiatric disordersWell-Being AssessmentAttention deficit hyperactivity disorderMost psychiatric disordersCanonical pathwaysSchool-based studyLarge public healthExpression profilingDeficit hyperactivity disorderRisk cohortPrevalent diagnosisPD groupMajor depressionHC groupMultiple comparison correctionSU73 GENE EXPRESSION IN BLOOD OF ADOLESCENTS WITH PSYCHIATRIC DISORDERS
Spindola L, Santoro M, Pan P, Talarico F, Xavier G, Carvalho C, Gadelha A, Salum G, Miguel E, Rohde L, Zanardo E, Kulikowski L, Bressan R, Ota V, Belangero S. SU73 GENE EXPRESSION IN BLOOD OF ADOLESCENTS WITH PSYCHIATRIC DISORDERS. European Neuropsychopharmacology 2019, 29: s927-s928. DOI: 10.1016/j.euroneuro.2017.08.262.Peer-Reviewed Original ResearchHigh-risk cohortPsychiatric disordersHealthy controlsGene expression profilingChild Behavior ChecklistEarly-onset psychiatric disordersBlood of adolescentsPrevious psychiatric disorderBlood gene expression profilingCross-sectional studyOnset psychiatric disordersWell-Being AssessmentAttention deficit hyperactivity disorderMost psychiatric disordersCanonical pathwaysSchool-based studyLarge public healthExpression profilingDeficit hyperactivity disorderRisk cohortPrevalent diagnosisPD groupMajor depressionHC groupMultiple comparison correction
2018
The economic impact of subthreshold and clinical childhood mental disorders
Fatori D, Salum G, Itria A, Pan P, Alvarenga P, Rohde L, Bressan R, Gadelha A, de Jesus Mari J, do Rosário M, Manfro G, Polanczyk G, Miguel E, Graeff-Martins A. The economic impact of subthreshold and clinical childhood mental disorders. Journal Of Mental Health 2018, 27: 588-594. PMID: 29708045, DOI: 10.1080/09638237.2018.1466041.Peer-Reviewed Original ResearchConceptsSubthreshold mental disordersClinical mental disordersMental disordersHigh Risk Cohort StudyCommon health problemLifetime cost estimatesChild mental disordersChildhood mental disordersWell-Being AssessmentSocial service useCohort studyYear old childrenService useEconomic burdenCost-effective programsHealth problemsBrazilian childrenCommunity studyMental healthOlder childrenDisordersDisorder assessmentSerious impairmentMajor Brazilian citiesChildren
2017
Low frequency fluctuation of brain spontaneous activity and obsessive-compulsive symptoms in a large school-age sample
Hoexter M, Biazoli C, Alvarenga P, Batistuzzo M, Salum G, Gadelha A, Pan P, Anés M, Mancini-Martins L, Moura L, Soriano-Mas C, Aquilla M, Amaro E, Rohde L, Jackowski A, Bressan R, Miguel E, do Rosario M, Sato J. Low frequency fluctuation of brain spontaneous activity and obsessive-compulsive symptoms in a large school-age sample. Journal Of Psychiatric Research 2017, 96: 224-230. PMID: 29102817, DOI: 10.1016/j.jpsychires.2017.10.009.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsBrain spontaneous activityLow-frequency fluctuationsSpontaneous activityRight sensorimotor cortexHigh Risk Cohort StudyState functional magnetic resonance imaging (rs-fMRI) dataSpontaneous activity changesPredictors of riskWell-Being AssessmentSpontaneous brain activitySuperior temporal cortexSuperior temporal gyrusCohort studyObsessive-compulsive disorderSensorimotor cortexMagnetic resonance imaging dataPsychiatric disordersOverall psychopathologyTemporal gyrusFractional amplitudeGeneral linear modelFunctional magnetic resonance imaging (fMRI) dataCompulsive symptomsBrain activity
2015
Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample
Cunha G, Asevedo E, Mansur R, Zugman A, Pan P, Gadelha A, Belangero S, Rizzo L, Coelho R, Stertz L, Cogo-Moreira H, Grassi-Oliveira R, Teixeira A, Kauer-Sant'Anna M, Mari J, Miguel E, Bressan R, Brietzke E. Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample. Acta Psychiatrica Scandinavica 2015, 133: 122-132. PMID: 26139469, DOI: 10.1111/acps.12453.Peer-Reviewed Original ResearchCluster of symptomsChild Behavior ChecklistPsychiatric diagnosisBrain-derived neurotrophic factorLarge community sampleImmune-inflammatory pathwaysEotaxin/CCL11CBCL total scoreWell-Being AssessmentCommunity sampleSchool-based studyIllness severityPeripheral biomarkersIL-6Neurotrophic factorPeripheral bloodMCP-1Older subjectsBehavioral symptomsMental disordersSignificant associationNeurodevelopmental psychopathologySymptomsSpecific disordersTotal score