2013
Can early improvement be an indicator of treatment response in obsessive-compulsive disorder? Implications for early-treatment decision-making
da Conceição Costa D, Shavitt R, Cesar R, Joaquim M, Borcato S, Valério C, Miguel E, Diniz J. Can early improvement be an indicator of treatment response in obsessive-compulsive disorder? Implications for early-treatment decision-making. Journal Of Psychiatric Research 2013, 47: 1700-1707. PMID: 23948637, DOI: 10.1016/j.jpsychires.2013.07.006.Peer-Reviewed Original ResearchConceptsBaseline Y-BOCS scoresSerotonin reuptake inhibitorsEarly improvementTreatment responseY-BOCS scoresBaseline Yale-Brown ObsessiveLogistic regressionAdequate pharmacological treatmentPotential predictive factorsWeeks of treatmentGreater reductionObsessive-compulsive disorder patientsStepwise logistic regressionWarrants further investigationYale-Brown ObsessiveClinical featuresReuptake inhibitorsObsessive-compulsive disorderPharmacological treatmentPredictive factorsMajor depressionDisorder patientsOCD treatment responseCompulsive ScaleWeeks
2005
Regional Gray Matter Abnormalities in Obsessive-Compulsive Disorder: A Voxel-Based Morphometry Study
Valente A, Miguel E, Castro C, Amaro E, Duran F, Buchpiguel C, Chitnis X, McGuire P, Busatto G. Regional Gray Matter Abnormalities in Obsessive-Compulsive Disorder: A Voxel-Based Morphometry Study. Biological Psychiatry 2005, 58: 479-487. PMID: 15978549, DOI: 10.1016/j.biopsych.2005.04.021.Peer-Reviewed Original ResearchConceptsVoxel-based morphometryObsessive-compulsive disorderGray matterLeft anterior cingulate cortexOCD patientsOCD subjectsParietal associative cortexMagnetic resonance imaging studyStructural magnetic resonance imaging (MRI) studiesRegional gray matter abnormalitiesGray matter reductionsGray matter abnormalitiesResonance imaging studyGray matter volumeAnterior cingulate cortexWarrants further investigationTemporolimbic regionsMedial thalamusBrain abnormalitiesObsessive-compulsive symptom severityHealthy volunteersImplicating dysfunctionMatter volumeAssociative cortexMorphometry study