Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder
Cappi C, Muniz R, Sampaio A, Cordeiro Q, Brentani H, Palácios S, Marques A, Vallada H, Miguel E, Guilherme L, Hounie A. Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder. Arquivos De Neuro-Psiquiatria 2012, 70: 87-90. PMID: 22311210, PMCID: PMC4479271, DOI: 10.1590/s0004-282x2012000200003.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderImmune systemTumor necrosis factor alpha genePrevalent psychiatric disordersInflammatory cytokine genesNecrosis factor alpha geneTNF-alpha geneRs361525 polymorphismUnknown etiologyHealthy controlsPsychiatric disordersCytokine genesA alleleFunctional polymorphismsOCD patientsOCD subjectsDisordersPathogenesisPLINK softwarePresent studyPolymorphismAdditional evidenceAssociation studiesPatientsEtiology