2024
An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis
Ramakrishnan D, Farhat L, Vattimo E, Levine J, Johnson J, Artukoglu B, Landeros-Weisenberger A, Zangen A, Pelissolo A, de B Pereira C, Rück C, Costa D, Mataix-Cols D, Shannahoff-Khalsa D, Tolin D, Zarean E, Meyer E, Hawken E, Storch E, Andersson E, Miguel E, Maina G, Leckman J, Sarris J, March J, Diniz J, Kobak K, Mallet L, Vulink N, Amiaz R, Fernandes R, Shavitt R, Wilhelm S, Golshan S, Tezenas du Montcel S, Erzegovesi S, Baruah U, Greenberg W, Kobayashi Y, Bloch M. An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis. Journal Of Psychiatric Research 2024, 173: 387-397. PMID: 38598877, DOI: 10.1016/j.jpsychires.2024.03.044.Peer-Reviewed Original ResearchConceptsYale-Brown Obsessive-Compulsive ScaleObsessive-compulsive disorderCGI-IRandomized-controlled trialsAdult obsessive-compulsive disorderClinical Global Impression ImprovementObsessive-Compulsive ScaleTreatment responseIndividual-patient data meta-analysisPosttreatment scoresEvaluation of treatment responseMeta-analysis of randomized-controlled trialsFirst-line therapyCGIIndividual participant dataMeta-analysisNovel treatment modalitiesExpert consensusIndividual participant data meta-analysisSystematic reviewDisordersData meta-analysisPosttreatmentRemission definitionsImpressive improvement
2023
Longitudinal invariance of psychotic experiences in children and adolescents: What do the data tell us?
Barbosa M, Machado V, Ziebold C, Moriyama T, Bressan R, Pan P, Rohde L, Miguel E, Fonseca L, Van Os J, Gadelha A. Longitudinal invariance of psychotic experiences in children and adolescents: What do the data tell us? Schizophrenia Research 2023, 255: 33-40. PMID: 36958268, DOI: 10.1016/j.schres.2023.03.003.Peer-Reviewed Original ResearchConceptsPsychotic experiencesTime pointsHigh-risk cohortPrevious systematic reviewDifferent age groupsDifferent time pointsBaseline evaluationLifetime psychotic experiencesPositive symptomsSystematic reviewAge groupsPerceptual abnormalitiesLongitudinal studyBrazilian High-Risk CohortPsychosis pronenessGood model fit indicesThree-factor solutionChildrenBrazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part II: cognitive-behavioral therapy
de Mathis M, Chacon P, Boavista R, de Oliveira M, de Barros P, Echevarria M, Ferrão Y, de Queiroz Vattimo E, Lopes A, Torres A, Diniz J, Fontenelle L, do Rosário M, Shavitt R, da Silva R, Miguel E, da Conceição Costa D. Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part II: cognitive-behavioral therapy. Brazilian Journal Of Psychiatry 2023, 45: 431-447. PMID: 37718254, PMCID: PMC10894635, DOI: 10.47626/1516-4446-2023-3081.Peer-Reviewed Original ResearchAdult obsessive-compulsive disorderObsessive-compulsive disorderTherapy treatmentHigh-quality scientific evidenceTreatment of adultsPrimary outcome measureHigh-quality evidenceAmerican Heart AssociationLevel of evidenceInternet-delivered CBTCognitive behavioral therapy treatmentBrazilian Research ConsortiumAdult patientsHeart AssociationClinical guidelinesTreatment recommendationsOutcome measuresAmerican CollegeSystematic reviewCBT interventionClinical interventionsCBT treatmentStudy designCBT protocolResponse prevention
2022
Ketamine in the Treatment of Obsessive-Compulsive Disorder: A Systematic Review
Bandeira ID, Lins-Silva DH, Cavenaghi VB, Dorea-Bandeira I, Faria-Guimarães D, Barouh JL, Jesus-Nunes AP, Beanes G, Souza LS, Leal GC, Sanacora G, Miguel EC, Sampaio AS, Quarantini LC. Ketamine in the Treatment of Obsessive-Compulsive Disorder: A Systematic Review. Harvard Review Of Psychiatry 2022, 30: 135-145. PMID: 35267254, DOI: 10.1097/hrp.0000000000000330.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSystematic reviewN-methyl-D-aspartate receptor antagonistAppropriate washout periodOpen-label trialPlacebo-controlled trialFirst-line treatmentRetrospective chart reviewUse of ketamineEffects of ketamineMeta-analysis protocolCombination of ketaminePubMed/MEDLINEPreferred Reporting ItemsMore effective treatmentsPotent N-methyl-d-aspartate receptor antagonistKetamine treatmentChart reviewGlutamate modulatorsGood tolerabilityReuptake inhibitorsWashout periodCase reportGlutamatergic neurotransmissionReceptor antagonist
2021
Mental health interventions following COVID-19 and other coronavirus infections: a systematic review of current recommendations and meta-analysis of randomized controlled trials
Damiano R, Di Santi T, Beach S, Pan P, Lucchetti A, Smith F, Forlenza O, Fricchione G, Miguel E, Lucchetti G. Mental health interventions following COVID-19 and other coronavirus infections: a systematic review of current recommendations and meta-analysis of randomized controlled trials. Brazilian Journal Of Psychiatry 2021, 43: 665-678. PMID: 33852690, PMCID: PMC8639008, DOI: 10.1590/1516-4446-2020-1582.Peer-Reviewed Original ResearchConceptsMental health interventionsSystematic reviewHealth interventionsCoronavirus disease 2019Non-RCT studiesCOVID-19Mental health strategiesMental health problemsMental health outcomesMental health issuesDisease 2019Psychiatric interventionCurrent recommendationsGeneral populationHealth strategiesHealth outcomesHealth problemsCoronavirus infectionHealth practitionersHealth issuesExpert recommendationsMore studiesInterventionTrialsReviewNeuroimaging Studies of Nonsuicidal Self-Injury in Youth: A Systematic Review
Brañas M, Croci M, Salto A, Doretto V, Martinho E, Macedo M, Miguel E, Roever L, Pan P. Neuroimaging Studies of Nonsuicidal Self-Injury in Youth: A Systematic Review. Life 2021, 11: 729. PMID: 34440473, PMCID: PMC8399885, DOI: 10.3390/life11080729.Peer-Reviewed Original ResearchNonsuicidal Self-InjuryTask-based fMRIFunctional neuroimaging techniquesNeural underpinningsEmotional processingNSSI behaviorsFuture longitudinal studiesSelf-InjuryNeuroimaging techniquesNSSIDevelopmental aspectsLongitudinal studyControl processStructural MRINeural pathwaysAPA PsycInfoSystematic reviewYouth populationSuicide preventionYouthSuicide attemptsJoanna Briggs InstitutePotential circuitPRISMA statement guidelinesGoogle Scholar databasesSubcutaneous Ketamine in Depression: A Systematic Review
Cavenaghi V, da Costa L, Lacerda A, Hirata E, Miguel E, Fraguas R. Subcutaneous Ketamine in Depression: A Systematic Review. Frontiers In Psychiatry 2021, 12: 513068. PMID: 34122156, PMCID: PMC8193034, DOI: 10.3389/fpsyt.2021.513068.Peer-Reviewed Original ResearchRobust antidepressant effectsRacemic ketamineSystematic reviewAntidepressant effectsMultiple dosesDose-titration approachRandomized clinical trialsRisk of biasTransitory side effectsInclusion/exclusion criteriaPubMed/MEDLINESystematic literature searchWeb of ScienceSubcutaneous ketamineCochrane riskRemission rateBias toolRetrospective studyBeneficial efficacySC routeClinical trials
2020
Population neuroscience: challenges and opportunities for psychiatric research in low- and middle-income countries
Cirillo A, Diniz E, Gadelha A, Asevedo E, Axelrud L, Miguel E, Rohde L, Bressan R, Pan P, de J. Mari J. Population neuroscience: challenges and opportunities for psychiatric research in low- and middle-income countries. Brazilian Journal Of Psychiatry 2020, 42: 442-448. PMID: 32267341, PMCID: PMC7430393, DOI: 10.1590/1516-4446-2019-0761.Peer-Reviewed Original ResearchConceptsMiddle-income countriesHigh-income countriesPopulation neuroscienceLongitudinal cohort studyCohort studyCohort designPsychiatric disordersElectronic searchMEDLINE databaseSystematic reviewBrain functioningCohortPsychiatric researchLMICsPsychiatry researchSearch criteriaKey studiesEMBASEEpidemiologyStudy
2015
Transcranial direct current stimulation in obsessive–compulsive disorder: emerging clinical evidence and considerations for optimal montage of electrodes
Senço N, Huang Y, D’Urso G, Parra L, Bikson M, Mantovani A, Shavitt R, Hoexter M, Miguel E, Brunoni A. Transcranial direct current stimulation in obsessive–compulsive disorder: emerging clinical evidence and considerations for optimal montage of electrodes. Expert Review Of Medical Devices 2015, 12: 381-391. PMID: 25982412, PMCID: PMC5777161, DOI: 10.1586/17434440.2015.1037832.Peer-Reviewed Original ResearchConceptsTranscranial direct current stimulationDirect current stimulationSystematic reviewCurrent stimulationPotential new treatmentPre-supplementary motor areaPubMed/MEDLINEObsessive-compulsive disorder (OCD) treatmentDeep brain stimulation trialsClinical evidenceObsessive-compulsive disorderStimulation trialsDBS trialsMotor areaRTMS targetsMagnetic stimulationEligibility criteriaNeuromodulation techniquesStimulation targetsDisorder treatmentNew treatmentsBrain circuitsDifferent electrode montagesTDCS montageTrials
2014
An updated review of antidepressants with marked serotonergic effects in obsessive–compulsive disorder
Pizarro M, Fontenelle L, Paravidino D, Yücel M, Miguel E, de Menezes G. An updated review of antidepressants with marked serotonergic effects in obsessive–compulsive disorder. Expert Opinion On Pharmacotherapy 2014, 15: 1391-1401. PMID: 24766145, DOI: 10.1517/14656566.2014.914493.Peer-Reviewed Original ResearchConceptsDouble-blind studyObsessive-compulsive disorderPathophysiology of OCDEfficacy of desvenlafaxineEfficacy of antidepressantsShort-term treatmentOlder antidepressantsSerotonergic effectsClinical trialsSerotonergic systemNew agentsAntidepressantsSystematic reviewReliable efficacyEfficacyUpdated reviewClomipramineOCD symptomsDisordersTreatmentCurrent studyReviewSSRIsDuloxetineMirtazapine