Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology
Mansur R, Cunha G, Asevedo E, Zugman A, Zeni-Graiff M, Rios A, Sethi S, Maurya P, Levandowski M, Gadelha A, Pan P, Stertz L, Belangero S, Anna M, Teixeira A, Mari J, Rohde L, Miguel E, McIntyre R, Grassi-Oliveira R, Bressan R, Brietzke E. Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology. PLOS ONE 2016, 11: e0160455. PMID: 27489945, PMCID: PMC4973983, DOI: 10.1371/journal.pone.0160455.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorThiobarbituric acid reactive substancesMental health problemsInterleukin-6Serum levelsHealth problemsSocioeconomic disadvantagePeripheral biomarkersSerum biomarkersOxidative stress markersAcid reactive substancesCross-sectional designChild Behavior Checklist DSMNeurotrophic factorHigher socioeconomic disadvantageSocio-demographic characteristicsBiomarker levelsNeurotrophic proteinsDomains of psychopathologyStress markersSpecific SubscaleCumulative risk modelBiomarkersMultiple biological systemsPathological neurodevelopmentAssociation of serum interleukin-6 with mental health problems in children exposed to perinatal complications and social disadvantage
Mansur R, Cunha G, Asevedo E, Zugman A, Rizzo L, Grassi-Oliveira R, Levandowski M, Gadelha A, Pan P, Teixeira A, McIntyre R, Mari J, Rohde L, Miguel E, Bressan R, Brietzke E. Association of serum interleukin-6 with mental health problems in children exposed to perinatal complications and social disadvantage. Psychoneuroendocrinology 2016, 71: 94-101. PMID: 27258821, DOI: 10.1016/j.psyneuen.2016.05.015.Peer-Reviewed Original ResearchConceptsParental mood disorderMental health problemsSerum interleukin-6Interleukin-6Perinatal complicationsEnvironmental risk factorsHealth problemsRisk factorsSerum levelsPsychiatric diagnosisParents' psychiatric diagnosisHigher serum levelsHigh Risk Cohort StudyMultiple risk factorsSocial disadvantageCohort studySystemic inflammationSocio-demographic characteristicsInflammatory activationMood disordersPsychiatric disordersDisorder pathogenesisComplicationsFamilial riskCumulative risk model