2023
Gamma knife capsulotomy for intractable OCD: Neuroimage analysis of lesion size, location, and clinical response
McLaughlin N, Magnotti J, Banks G, Nanda P, Hoexter M, Lopes A, Batistuzzo M, Asaad W, Stewart C, Paulo D, Noren G, Greenberg B, Malloy P, Salloway S, Correia S, Pathak Y, Sheehan J, Marsland R, Gorgulho A, De Salles A, Miguel E, Rasmussen S, Sheth S. Gamma knife capsulotomy for intractable OCD: Neuroimage analysis of lesion size, location, and clinical response. Translational Psychiatry 2023, 13: 134. PMID: 37185805, PMCID: PMC10130137, DOI: 10.1038/s41398-023-02425-2.Peer-Reviewed Original ResearchConceptsY-BOCS reductionObsessive-compulsive disorderGamma knife capsulotomyLesion sizeRefractory obsessive-compulsive disorderOverall lesion volumeIntractable obsessive-compulsive disorderLesion-symptom mappingVoxel-wise lesion-symptom mappingClinical improvementClinical responseWhite matter pathwaysClinical outcomesFull respondersConventional therapyInternal capsuleLesion characteristicsLesion volumeAnterior limbEffective treatmentLesion locationLesion occurrenceCoronal planeSize/locationPatients
2021
Neurocircuitry of Deep Brain Stimulation for Obsessive-Compulsive Disorder as Revealed by Tractography: A Systematic Review
Vieira E, Arantes P, Hamani C, Iglesio R, Duarte K, Teixeira M, Miguel E, Lopes A, Godinho F. Neurocircuitry of Deep Brain Stimulation for Obsessive-Compulsive Disorder as Revealed by Tractography: A Systematic Review. Frontiers In Psychiatry 2021, 12: 680484. PMID: 34276448, PMCID: PMC8280498, DOI: 10.3389/fpsyt.2021.680484.Peer-Reviewed Original ResearchDeep brain stimulationObsessive-compulsive disorderBrain stimulationEffects of DBSMechanisms of DBSRefractory obsessive-compulsive disorderOCD patientsVentral anterior limbDifferent white matter pathwaysCorresponding clinical outcomesDiffusion-weighted imagingDifferent fiber tractsDiffusion tensor imagingPostoperative periodWhite matter pathwaysClinical outcomesInternal capsuleFavorable outcomeDBS effectsDTI-MRIAnterior limbAffective symptomsElectronic databasesWhite matterPatients
2020
Delayed Brain Cyst Formation After Gamma Knife Anterior Capsulotomy
Kasabkojian S, Dwan A, Maziero M, de Salles A, Gorgulho A, Miguel E, Fillipo de Queiroz Vattimo E, Lopes A. Delayed Brain Cyst Formation After Gamma Knife Anterior Capsulotomy. World Neurosurgery 2020, 145: 298-300. PMID: 33022431, DOI: 10.1016/j.wneu.2020.07.199.Peer-Reviewed Original ResearchConceptsRefractory obsessive-compulsive disorderAnterior capsulotomyObsessive-compulsive disorderBrain cyst formationFrontal lobe symptomsMagnetic resonance imagingAnterior frontal regionsPostoperative monthBrain cystsBrain edemaManic episodesVisual hallucinationsRadiosurgical proceduresAbnormal complicationsHigh dosesCapsulotomyResonance imagingObsessive-compulsive symptomsCyst formationEffective optionLeft hemisphereRight hemisphereFrontal regionsComplicationsSymptoms
2015
Visuospatial Memory Improvement after Gamma Ventral Capsulotomy in Treatment Refractory Obsessive–Compulsive Disorder Patients
Batistuzzo M, Hoexter M, Taub A, Gentil A, Cesar R, Joaquim M, D'Alcante C, McLaughlin N, Canteras M, Shavitt R, Savage C, Greenberg B, Norén G, Miguel E, Lopes A. Visuospatial Memory Improvement after Gamma Ventral Capsulotomy in Treatment Refractory Obsessive–Compulsive Disorder Patients. Neuropsychopharmacology 2015, 40: 1837-1845. PMID: 25645373, PMCID: PMC4839507, DOI: 10.1038/npp.2015.33.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRefractory OCD patientsOCD patientsVisuospatial memory performanceComprehensive neuropsychological evaluationObsessive-compulsive disorder patientsTreatment-refractory obsessive-compulsive disorder patientsCognitive flexibilityNeuropsychological domainsMemory performanceVisuospatial learningNeuropsychological functioningVisuospatial perceptionIntellectual functioningInhibitory controlRefractory obsessive-compulsive disorderTreatment-refractory OCD patientsMemory improvementGamma ventral capsulotomyMotor functioningNeuropsychological evaluationNeuropsychological outcomesEffects of GVCMotor performanceFunctioning
2010
Response to Sham and Active Gamma Ventral Capsulotomy in Otherwise Intractable Obsessive-Compulsive Disorder
Gouvea F, Lopes A, Greenberg B, Canteras M, Taub A, Mathis M, Miguel E. Response to Sham and Active Gamma Ventral Capsulotomy in Otherwise Intractable Obsessive-Compulsive Disorder. Stereotactic And Functional Neurosurgery 2010, 88: 177-182. PMID: 20431329, DOI: 10.1159/000313870.Peer-Reviewed Original ResearchConceptsRefractory obsessive-compulsive disorderGamma ventral capsulotomyClinical responseSham surgeryObsessive-compulsive disorderSurgical techniquePsychopathological changesRadiosurgical proceduresRemarkable ameliorationActive interventionCompulsive disorderDisordersActive procedureCapsulotomySurgeryShamRadiosurgery
2009
Neuropsychological Outcome of Ventral CapsularVentral Striatal Gamma Capsulotomy for Refractory Obsessive-Compulsive Disorder: A Pilot Study
Taub A, Lopes A, Fuentes D, D'Alcante C, de Mathis M, Canteras M, Siviero M, Greenberg B, Norén G, Batistuzzo M, Hoexter M, Cecílio S, Savage C, Rasmussen S, Miguel E. Neuropsychological Outcome of Ventral CapsularVentral Striatal Gamma Capsulotomy for Refractory Obsessive-Compulsive Disorder: A Pilot Study. Journal Of Neuropsychiatry 2009, 21: 393-397. PMID: 19996247, DOI: 10.1176/jnp.2009.21.4.393.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderObsessive-compulsive patientsProfound cognitive deficitsAbstract reasoningNeuropsychological batteryRefractory obsessive-compulsive disorderCognitive deficitsNeuropsychological outcomesGamma knife capsulotomyMemoryVocabularyPilot studyDeficitsReasoningLearningDisordersAttentionBatteries
2008
Gamma ventral capsulotomy for treatment of resistant obsessive-compulsive disorder: A structural MRI pilot prospective study
Cecconi J, Lopes A, de Souza Duran F, Santos L, Hoexter M, Gentil A, Canteras M, de Castro C, Norén G, Greenberg B, Rauch S, Busatto G, Miguel E. Gamma ventral capsulotomy for treatment of resistant obsessive-compulsive disorder: A structural MRI pilot prospective study. Neuroscience Letters 2008, 447: 138-142. PMID: 18835422, DOI: 10.1016/j.neulet.2008.09.061.Peer-Reviewed Original ResearchConceptsGamma ventral capsulotomyObsessive-compulsive disorderRefractory obsessive-compulsive disorderResistant obsessive-compulsive disorderRefractory OCD patientsYear of radiosurgeryPilot prospective studyVoxel-based morphometry methodRegional structural abnormalitiesGray matter volumeRight inferior frontal gyrusInferior orbitofrontal cortexPostoperative increaseProspective studyInferior frontal gyrusMagnetic resonance imaging dataMatter volumeMRI scansNeurobiological changesStructural abnormalitiesOrbitofrontal cortexCapsulotomyPatientsOCD patientsFrontal gyrus